Objectives: To determine the effectiveness of Peruvian purple corn (Zea mays) administration in serum lipids levels reduction (hypolipidemic effect) in non hypertensive diabetic patients with dyslipidemia; to compare hypolipidemic effect of Peruvian purple corn and simvastatin. Design: Clinical essay. Setting: Instituto de Investigaciones Clinicas, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Peru. Participants: Non hypertensive dyslipidemic diabetic patients. Interventions: Between January and October 2006 two groups of 15 non hypertensive dyslipidemic diabetic patients were randomly formed, patients with recent diagnosis, without previous treatment and without chronic complications; one group recieved simvastatin 40 mg/day and the other group Peruvian purple corn (dehydrated and micropulverized pills 1g/day) for 30 days. Patients had low fat diet with weekly nu...

Objective: To establish the effect of fresh maca (Lepidum meyenil walp) on the sportsmen physical performance at high altitude. Design: Comparative, prospective, and experimental study. Materials and Methods: Ten high altitude sportsmen constituted the sample. We first measured the maximum oxygen consumption under physical activity. Then they received 1500 mg of fresh maca daily during 60 days and a second evaluation was performed under similar conditions. The maximum oxygen intake and performance were determined and subjects were monitored for a 30 days period. Dosage of transaminases ALAT, ASAT, and serum creatinine were done during each evaluation. Results: In basal conditions the velocity average in the treadmill was 15,46 km/h and the maximum oxygen intake average was 52,32 mL/kg/min. In the second evaluation following the fresh maca consume the average of the maximum velocity raise...

OBJECTIVE: To demostrate that human immunodeficiency virus (HIV) patients in acquired immunodeficiency syndrome (AIDS) phase associated with tuberculosis (TB) or cryptococcosis have hypomagnesemia-related inadequate treatment response. DESIGN: Prospective and longitudinal study. MATERIALS AND METHODS: We studied 300 subjects, divided in six groups of 50 patients each: positive HIV patients, TB patients, AIDS patients with TB, AIDS patients with cryptococcosis, no-AIDS patients with acute infections and a normal group (blood donors). RESULTS: Average magnesium values were below normal in the groups AIDS/TB, AIDS/cryptococcosis and TB. There were important statistical differences in magnesium levels in the groups HIV, AIDS/TB, AIDS/ cryptococcosis and TB. With respect to hypomagnesemia, the group with less response to treatment was the AIDS+TB (27%). CONCLUSIONS: Hypomagnesemia is prevalen...

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Objetivos: Evaluar el efecto hipolipemiante del aceite de sacha inchi. Diseño: Estudio experimental, doble ciego, con grupo control comparativo. Institución: Instituto de Investigaciones Clínicas, Facultad de Medicina, UNMSM. Participantes: Pacientes diabéticos tipo 2 con dislipoproteinemia. Intervenciones: Se ingresó al estudio a 48 pacientes diabéticos tipo 2 con dislipoproteinemia, de ambos géneros, de 40 a 70 años de edad, sin obesidad mórbida. Mediante una lista aleatoria, 15 recibieron simvastatina 20 mg + aceite placebo (grupo 1) y 14 aceite de sacha inchi + 1 comprimido placebo (grupo 2), durante 4 meses. En ayunas, se midió colesterol total (CT), colesterol HDL (HDL), triglicéridos (Tg), glucosa (G) y hemoglobina glicosilada (HbA1c), por métodos enzimáticos convencionales. Principales medidas de resultados: VLDL y LDL y colesterol no-HDL. Resultados: En el análisis...

Objective: To determine the frequency of cardiovascular risk factors (CVRF) in obese menopausal and premenopausal women aged 30 to 75 from Metropolitan Lima, Peru. Methods: We conducted a descriptive, analytical, transversal study in 95 obese women aged 30 to 75 from Metropolitan Lima from 2015 to 2017, where 48 were menopausal (MENO) and 47, premenopausal (PREMENO). Obesity grade was determined using the World Health Organization criteria. Conventional methods were used for anthropometry, blood pressure (BP), fasting blood glucose (G), total cholesterol (TC), triglycerides, HDL cholesterol, insulin (I) and transaminases values; VLDL, LDL and non-HDL (cNoHDL), and HOMA coefficient were calculated. We used the program SPSS v. 23 for statistical analysis. We considered obesity, dyslipoproteinemia, high blood pressure, insulin resistance and high transaminases values as CVRF. Results: From ...

Objectives: To compare the hypolipemic effect of Sacha Inchi/galactomannan´s emulsion (SIE) with Simvastatin (SVT) in diabetics type 2 (DM2) with dislipoproteinemia. Methodology: A doble- blind, randomized, comparative-controlled study was performed. A total of 41 DM2 patients with dislipoproteinemia, both genders, 40 to 70 years old were included. At random, group 1 received SVT 20 mg + placebo emulsion (n=20) and group 2 received 10 ml SIE (sacha inchi, Plukenetia huayllabambana variety, conteining 2g omega-3 fatty acids + 0.03 g de galactomannans from de Tara gum, Caesalpinia spinosa ) + placebo pill (n=21) during 4 months. At fasting total cholesterol (TC), HDL cholesterol (cHDL), triglycerides (Tg), glucose (G), glicosilated hemoglobin (HbA1c), creatinine, trasaminases and TSH were measured by conventional methods, insulin by immunoluminiscence at the begining and every month ...

Objectives: To determine the type of anemia most frequent in patients with AIDS and the various degrees of anemia. Material and methods: One hundred patients 18 to 60 year-old infected with human immune deficiency virus (HIV) with residence in Lima and Callao were studied from January to December 2001 for blood count bone marrow aspiration, serum iron, transferrin, ferritin, folate and vitamin B12 levels. Samples were evaluated at the “Dos de Mayo” Hospital Clinical Pathology Department. Results: From the 100 patients, 60% had severe, 30% moderate and 10% light anemia; 70% nutritional and 30% due to chronic disease. In the nutritional anemia group, 25% was ferropenic anemia, 30% ferropenic and megaloblastic (double defect) and 15% megaloblastic. In the megaloblastic anemia group, 30 patients had folate deficiency and 15 vitamin B12 deficiency. Conclusions: Prevalent anemia was nutrit...

We report 16 cases of Pemphigus foliaceus occurred at Ucayali, department of Peru. Most of them came from Coronel Portillo, Ucayali’s province (94%), and half of them from Campo Verde district. Eighty per cent belonged to rural areas, 56% were females and 7 children were affected (43%). All patients had generalized skin involvement without mucous membranes compromise. Nikolsky sign was present in 50%. In all cases skin biopsy showed subcorneal acantholysis and only 40% presented pemphigus positive immunofluorescence.

Introduction: In our context, there are no studies which had evaluated the markers of bone turnover in postmenopausal women with osteoporosis, considering the high rate of morbidity and mortality associated with fragility fractures. Objective: To know the biochemical features of bone metabolism in women with postmenopausal osteoporosis. Methods: A cross-sectional study. 49 women with postmenopausal osteoporosis were included. Bone mineral density in spine, hip and forearm was measured by dual x-ray absorptiometry. Calcium, phosphorus, osteocalcin, alkaline phosphatase, vitamin D and paratohormone were measured in blood. N-telopeptide of collagen type I, calcium and phosphorus were measured in urine by conventional methods. Results: The average age of the participants was 59,1± 7,5 years. The average time since menopause was 12,0 ± 7,9 years. All ...

Background: Previous studies have shown oxidative stress in pemphigus vulgaris and pemphigus foliaceus, nevertheless, it remains unknown whether a similar response is characteristic of endemic pemphigus foliaceus in Peru. Objectives: To determine the oxidative stress response in endemic pemphigus foliaceus patients and subjects with positive for anti-desmoglein1 antibodies (anti-dsg1) from endemic areas of Peru. Subjects and Methods: This is a cross-sectional study. The study population included 21 patients with Endemic Pemphigus foliaceus and 12 healthy subjects with anti-dsg1 antibodies from the Peruvian Amazon (Ucayali), as well as 30 healthy control subjects. Malondialdehyde, an indicator of lipid peroxidation by free radicals, was measured in serum. Results: We collected 21 cases of endemic pemphigus foliaceus, 15 of them with active chronic disease and 6 in clinical remission. Seru...

Objective: To determine efficacy and security of of Annona muricata L (guanábana) leaves ethanolic extract plus glibenclamide capsules in controlling glucose levels in type 2 diabetes mellitus patients compared to patients receiving with glibenclamide alone. Design: Randomized, double-blind, parallel-group controlled clinical trial. Setting: Internal Medicine service, Tingo María-EsSalud Hospital I, Huanuco city. Par ticipants: Type 2 diabetes mellitus patients. Interventions: Between May 2007 and September 2007 sixty 38 to 60 year-old patients were randomly assigned to 6 groups, 3 receiving capsules containing 180 mg of Annona muricata L leaves ethanolic extract plus glibenclamide 5 mg and 3 receiving glibenclamide 5 mg tablets only. Main outcome measurements: Reduction of glycemia. Results: There was reduction of glycemic levels, higher in those receiving guanabana plus glibenclamida...

We report the case of a 31 year-old male from Cajamarca, Peru, with cognitive problems since childhood, who at 12 year-old developed increased volume and deformation of his right lower limb and to a lesser extent of his left, associated to massive skin folding, growth of subcutaneous nodules, elephantine look due to nerve cords formation in thigh and leg, pain and functional walking limitation. Concomitantly generalized skin café au lait spots, subcutaneous nodules, and Lisch nodules in both irides. Magnetic resonance and contrast TAC revealed abundant uniform plexiform nodules in abdomino-pelvic cavity forming masses and cords that continued throughout his thigh as lumps and cords. In addition, the patient presented bone dysplasia (thinning of femur and tibia cortex, pseudoarthrosis, new left cotyle formation). Contrast magnetic resonance showed triventricular normotensive hydrocephalu...

Objetivos: Validar 3 instrumentos de evaluación de procesos de capacitación sobre violencia. Diseño: Análisis descriptivo, observacional, prospectivo del desempeño laboral de participantes posterior a su capacitación. Institución: El Programa Permanente de Capacitación para la Atención Integral de Víctimas de Violencia, Facultad de Medicina, UNMSM, impartió la Diplomatura de Atención Integral en Salud a Víctimas de Violencia y el Curso TOT. Participantes: Profesionales de salud y profesores universitarios de 12 regiones del país. Intervenciones: 70 profesionales de salud y profesores universitarios de 12 regiones del país recibieron ambas capacitaciones. Para evaluar el efecto de dicha capacitación, se elaboró 3 instrumentos: a) Cuestionario de Seguimiento a Ex alumnos, validado por grupos focales; permitió recabar información personal, laboral, de acciones prestaciona...

Objective. To evaluate the importance of bone biopsy in the diagnose of the bone metabolic diseases, its relationship with bone densitometry (BMD) and biomarkers. Methods. In a descriptive, transversal study, 38 biopsies of pelvic bone were made, 36 in female (34 postmenopausal and 2 premenopausal) and 2 in male. All had BMD in spine, hip and/or forearm measured by dual x-ray absorptiometry. Calcium, phosphorus, parathormone, vitamin D, alkaline phosphatase, osteocalcin, hemoglobin, transaminases, total protein and fractions were measured in blood and N-telopeptide of collagen type I, calcium and phosphorus in urine by conventional methods. Results. The mean age of 34 menopausal women was 58 ± 7,79 and menopause time was 11,48 ± 8,76 years; mean BMD in spine, hip and forearm were -2,88 ± 1,16, -2,13 ± 0,82, y - 5,14 ± 1,76, respectively; bone biopsy demonstrated osteoporosis in 33 y...

Estudio clínico, aleatorio, grupo paralelo, doble ciego, realizado en el Servicio de Medicina Interna del Hospital I Tingo María, de EsSalud, en el Departamento de Huánuco, para determinar la eficacia y seguridad de cápsulas de extracto etanólico de hojas de Annona muricata L (guanábana) más glibenclamida, para un mejor control de los niveles de glicemia comparado con la administración de glibenclamida sola, en pacientes con diabetes mellitus tipo 2. Entre mayo y setiembre de 2007, 60 pacientes fueron asignados a 6 grupos de manera aleatoria; 3 grupos recibieron cápsulas conteniendo 180 mg de extracto etanólico de hojas de Annona muricata L. más 5 mg de glibenclamida, los otros 3 grupos continuaron solo con glibenclamida, y se evaluaron los niveles de glicemia. Se encontró disminución del nivel de glicemia, siendo mayor el efecto en aquellos que recibieron guanábana más gl...

El Pénfigo Foliáceo Endémico (PFE) es una enfermedad autoinmune de la piel endémica en áreas de la Amazonía. Se revisa el caso de una mujer de 36 años que presentó PFE en la semana 17 de embarazo. A las 29 semanas, comenzó un tratamiento antimicrobiano y esteroides. En el momento del parto la enfermedad en la madre ya había sido controlada con corticoterapia, mostrando inmunofluorescencia indirecta (IFI) para IgG total negativa. De esta manera no habría descarga de anticuerpos hacia la placenta, y la recién nacida también mostró títulos negativos. Durante el seguimiento la niña varió sus títulos de anticuerpos, de negativo a 1/20. Recientemente se demostró que 45% de familiares de pacientes con PFE presentan anticuerpos anti Dsg-1, siendo más frecuente en familiares de primer grado.

Introduction: endemic pemphigus foliaceus (PFE) has been described at the beginning of the 50s in the peruvian forest. In 2006,Ortega & col. reported the presence of desmoglein 1 antibodies in Pueblo Libre, Ucayali. Nevertheless, immune reports does not exist on patients’ relatives with PFE in the zone.Objetives: to compare the immunopathologic profiles of healthy subjects from Pueblo Libre (an area in Ucayali, endemic for pemphigus foliaceus), with healthy relatives of patients with endemic pemphigus foliaceus (EPF) and healthy controls from non-endemic areas.Materials and methods: this is a prospective multicentric study performed from June to August 2006. The sample consisted of 41 healthy subjects from the Pueblo Libre community, 11 relatives of EPF patients and 20 healthy subjects from non-endemic areas. Blood samples were obtained for immunopathologic studies (E...

Introduction: endemic pemphigus foliaceus (PFE) has been described at the beginning of the 50s in the peruvian forest. In 2006,Ortega & col. reported the presence of desmoglein 1 antibodies in Pueblo Libre, Ucayali. Nevertheless, immune reports does not exist on patients’ relatives with PFE in the zone.Objetives: to compare the immunopathologic profiles of healthy subjects from Pueblo Libre (an area in Ucayali, endemic for pemphigus foliaceus), with healthy relatives of patients with endemic pemphigus foliaceus (EPF) and healthy controls from non-endemic areas.Materials and methods: this is a prospective multicentric study performed from June to August 2006. The sample consisted of 41 healthy subjects from the Pueblo Libre community, 11 relatives of EPF patients and 20 healthy subjects from non-endemic areas. Blood samples were obtained for immunopathologic studies (E...

Objetive: To determine efficacy and safety of capsaicin 0,075% topical therapy in the treatment of pruritus due to eosinophilic folliculitis in HIV patients with lymphocyte count CD4 (+) <250 x mm3. Design: Randomized clinical trial, double blind study. Setting: Infectious and Tropical Diseases Service and Dermatology Service, Hospital Nacional Dos de Mayo, Lima, Peru. Participants: Patients with VIH-associated eosinophilic folliculitis. Interventions: Forty patients with HIV-associated eosinophilic folliculitis were randomly distributed in two groups: group 1 included 20 patients that received sample 1 and group 2, 20 patients that received sample 2. Patients received capsaicin 0,075% and menthol 1% treatments (marked as sample 1 and sample 2). Instructions on topical use each 6 hours were given to patients. Visits were programmed to evaluate efficacy and monitor adverse events by st...