Objetive. To study the frequency and characteristics of an obese population with and without cardiometabolic risk (CMR) and, to revise the concept of cardiometabolically healthy obese CMHO subjects. Material and methods. A total of 105 obese subjects, 30 to 75 years old, were recluted from a preventive-promotional program from may 2015 to april 2016. Previous informed consent, age, gender, anthropometric measures, blood pressure (BP), personal and family history of cardiovascular risk factors (CVRF) were registered. At fasting glucose (G), total cholesterol (TC), HDL cholesterol (cHDL), triglycerides (Tg), creatinine, plasma proteins, bilirrubins, transaminases (AST,ALT), alkaline fosfatase (FA) and gamaglutamyltranspeptidase (GGTP) were measured in blood by conventional methods. VLDL, LDL, Non-HDL fractions were calculated. Statistics were calculated with SPSS.23 program. Results. 77,4%...

Objectives: To study basal and postprandial intermediary metabolism in normal postmenopausal high-altitude female dwellers, adapted to an environment characterized by low barometric and oxygen pressures and hypoxia. Methodology: An experimental study with control group was conducted; 20 normal high-altitude female dwellers –HAD- (Cusco, Peru, 3 395 meters above sea level-m.a.s.l.) and 16 normal sea level female dwellers –SLD- (Lima, Peru, 150 m.a.s.l.), 40 to 70 years old, postmenopausal, were included. Fasting glucose (G), total cholesterol (TC), HDL, triglycerides (Tg), insulin (I) and non-esterified fatty acids (NEFA) were measured in blood by conventional methods, and VLDL, LDL, non-HDL and HOMA were calculated. G, I, Tg, and NEFA were determined for 6 hours following the ingestion of a mixed meal containing 730 Kcal. Results: At fasting, the HAD had lower G and higher NEFA value...

Objective: To determine the frequency of cardiovascular risk factors (CVRF) in obese menopausal and premenopausal women aged 30 to 75 from Metropolitan Lima, Peru. Methods: We conducted a descriptive, analytical, transversal study in 95 obese women aged 30 to 75 from Metropolitan Lima from 2015 to 2017, where 48 were menopausal (MENO) and 47, premenopausal (PREMENO). Obesity grade was determined using the World Health Organization criteria. Conventional methods were used for anthropometry, blood pressure (BP), fasting blood glucose (G), total cholesterol (TC), triglycerides, HDL cholesterol, insulin (I) and transaminases values; VLDL, LDL and non-HDL (cNoHDL), and HOMA coefficient were calculated. We used the program SPSS v. 23 for statistical analysis. We considered obesity, dyslipoproteinemia, high blood pressure, insulin resistance and high transaminases values as CVRF. Results: From ...

Introduction. The therapeutic support of the metabolic control of diabetes mellitus type 2 (DM2) are the diet and physical activity.Objetive: To study the effect of a short and casual exercise on the basal and postprandial intermediary metabolism of individuals with DM2. Methods. A total of 16 female and 15 male, DM2 patients, 40 to 68 years old, were included in a experimental, tranversal study. They were submitted to a basal (A) and post-exercise (B) tests, the last one consisting in 30 minutes walking at 4 Km/hour on a treadmill, Under fasting, state, glucose, total cholesterol , HDL cholesterol, triglycerides, insulin and non-sterified fatty acids (NEFA) were measured in blood. Cholesterol VLDL, LDL, Non-HDL and HOMA were calculated. After a breakfast consisting in 55,5% fat, 37,2 % carbohydrates, 7,34% proteins containing 730 Kcal, glucose, insulin...

Objetivos: Evaluar el efecto hipolipemiante del aceite de sacha inchi. Diseño: Estudio experimental, doble ciego, con grupo control comparativo. Institución: Instituto de Investigaciones Clínicas, Facultad de Medicina, UNMSM. Participantes: Pacientes diabéticos tipo 2 con dislipoproteinemia. Intervenciones: Se ingresó al estudio a 48 pacientes diabéticos tipo 2 con dislipoproteinemia, de ambos géneros, de 40 a 70 años de edad, sin obesidad mórbida. Mediante una lista aleatoria, 15 recibieron simvastatina 20 mg + aceite placebo (grupo 1) y 14 aceite de sacha inchi + 1 comprimido placebo (grupo 2), durante 4 meses. En ayunas, se midió colesterol total (CT), colesterol HDL (HDL), triglicéridos (Tg), glucosa (G) y hemoglobina glicosilada (HbA1c), por métodos enzimáticos convencionales. Principales medidas de resultados: VLDL y LDL y colesterol no-HDL. Resultados: En el análisis...

Objectives: To compare the hypolipemic effect of Sacha Inchi/galactomannan´s emulsion (SIE) with Simvastatin (SVT) in diabetics type 2 (DM2) with dislipoproteinemia. Methodology: A doble- blind, randomized, comparative-controlled study was performed. A total of 41 DM2 patients with dislipoproteinemia, both genders, 40 to 70 years old were included. At random, group 1 received SVT 20 mg + placebo emulsion (n=20) and group 2 received 10 ml SIE (sacha inchi, Plukenetia huayllabambana variety, conteining 2g omega-3 fatty acids + 0.03 g de galactomannans from de Tara gum, Caesalpinia spinosa ) + placebo pill (n=21) during 4 months. At fasting total cholesterol (TC), HDL cholesterol (cHDL), triglycerides (Tg), glucose (G), glicosilated hemoglobin (HbA1c), creatinine, trasaminases and TSH were measured by conventional methods, insulin by immunoluminiscence at the begining and every month ...

Objective: To determine the presence of insulin resistance (IR) in a group of overweight and obese adolescents. Materials and Methods: One hundred 10 to 28 year-old children were studied, (77% females); 67% were overweight and the remaining obese. Overweight and obesity were determined by Must et al. criteria: overweight between 85 and 95 percentile and obesity overt the 95 percentile. Glycemia and basal insulin were determined in serum obtained by vein puncture. IR was determined by HOMA’s index considering Keskin diagnosis value of 3,1. Results: There was no biochemical statistical difference between the overweight and obesity groups; 14% showed IR, 16,2% in the obese children and 12,3% in those overweight. Average insulin and HOMA in obese children with IR were 315 uUl/mL and 7, respectively. The insulin and HOMA difference between those with and without IR was statistically signifi...

It has been demonstrated that obesity produces insulin resistance, dislipidemia, high blood pressure and other metabolic alterations which are risk factors to develop atherosclerosis and cardiovascular events. On the other land, chronic expossure to high altitude increases the insulin sensibility; the blood glucose concentration, total and LDL cholesterol are lower in high altitude dwellers than in sea level inhabitants, and HDL cholesterol is higher. Therefore, it seemed interesting to study the metabolic events in the obese people living at high altitude. A total of 41 male obese, aged 20 to 60 years, were studied; 11 living at sea level (Lima, 150 m above sea level) and 30 living at high altitude (Huancayo 3200 m above sea level). Oral glucose tolerance tests consisting in 75 g were conducted in these subjects. Anthropometric measures (height, weight, body mass index, abdominal ship i...

Objective: To study and to compare the basal and postprandial intermediary metabolism of patients with diabetes mellitus type 2 (DM2) both at sea level (SL) as well as at high altitude (HA). Methodology: a total of 33 normal dwellers and 33 DM2 patients of SL(Lima, 150 meters above sea level- masl-) and 30 normal dwellers and 28 DM2 patients of HA(Cusco, 3,395 masl), of both genders, 40 to 70 years old were included. Body mass index (BMI) and abdominal circunference (AC) were measured. Glucose (G), total cholesterol (TC), HDL cholesterol (HDL), triglycerides (Tg), insulin (I) and non-esterified fatty acids (NEFA) were measured in blood at fasting, Cholesterol VLDL,LDL, NOHDL and HOMA coefficient were calculated; thereafter and during 6 hours after ingestion of a standardized mixed meal containing 730 Kcal G, I, Tg and NEFA were measured in blood. Statistical calculations were done by mea...

OBJETIVE: To determine normal metabolism variations following food ingestion. MATERIAL AND METHODS: A total of 33 normal middle-aged and old adults, 16 female and 17 male, 45-70 years old (average 56,3 ± 7,32), were studied both after a 12-14 hours nocturnal fast and following ingestion of a food mixture containing 730 kcal, 55,4% fat, 37,2% carbohydrates and 7,4% protein, an almost standard breakfast. Blood samples were obtained at fasting state and during 6 hours after the ingestion of the meal described before. Glucose, triglycerides, total cholesterol and HDL cholesterol were measured by enzymatic methods, insuline by radioimmune assay and non–esterified fatty acids (NEFA) by the method of Duncombe. RESULTS: Blood glucose rose from 30 minutes to the 2nd hour; insulin from 30 minutes to the 4th hour, triglycerides rose from the 2nd to 4th hour and then began to decline at the 6th h...

Introduction: Obesity is a public health problem that tends to increase and compromises the health of people. Objectives: To determine the prevalence of metabolically normal obese (OMN) subjects depending on the presence of cardiovascular risk factors in an adult population showing obesity and morbid obesity. Design: Observational, descriptive and cross-section study. Setting: Department of Endocrinology, Hospital Dos de Mayo, Lima, Peru. Participants: Obese adults without metabolic diseases. Interventions: the study was conducted during the period between April 2009 and May 2010 in all adults consulting for obesity and who declared not having type 2 diabetes mellitus, arterial hypertension or dyslipidemia. Weight, height and waist circumference (WC) were obtained, and body mass index (BMI) was calculated. Those who had 30 kg/m2 or more were included in the study. Insulin, glucose and li...