OBJETIVE: To determine normal metabolism variations following food ingestion. MATERIAL AND METHODS: A total of 33 normal middle-aged and old adults, 16 female and 17 male, 45-70 years old (average 56,3 ± 7,32), were studied both after a 12-14 hours nocturnal fast and following ingestion of a food mixture containing 730 kcal, 55,4% fat, 37,2% carbohydrates and 7,4% protein, an almost standard breakfast. Blood samples were obtained at fasting state and during 6 hours after the ingestion of the meal described before. Glucose, triglycerides, total cholesterol and HDL cholesterol were measured by enzymatic methods, insuline by radioimmune assay and non–esterified fatty acids (NEFA) by the method of Duncombe. RESULTS: Blood glucose rose from 30 minutes to the 2nd hour; insulin from 30 minutes to the 4th hour, triglycerides rose from the 2nd to 4th hour and then began to decline at the 6th h...

A review of the lipidic and non-lipidic cardiovascular risk factors is done. The increase of LDL, VLDL, IDL cholesterol, non-HDL triglycerides and lipoprotein(a) as well as HDL cholesterol decrease were considered as main lipidic cardiovascular risk factors. Dyslipoproteinemias are classified as primary and secondary. Primary dyslipoproteinemias are inborn errors of lipid metabolism, familiar or non-familiar, including common hypercholesterolemia, combined familiar hyperlipidemia, familiar hypercholesterolemia, familiar hypertrigliceridemia, VLDL remanents hyperlipidemia and primary quilomicronemia. The secondary dyslipoproteinemias are produced by various diseases, including hypotiroidism, diabetes mellitus, nephrotic syndrome, chronic biliary obstruction, renal insufficiency and so on; there are some drugs that modify lipid metabolism such as alcohol, beta-blockers, diuretics, progesta...

Objetivos: Evaluar el efecto hipolipemiante del aceite de sacha inchi. Diseño: Estudio experimental, doble ciego, con grupo control comparativo. Institución: Instituto de Investigaciones Clínicas, Facultad de Medicina, UNMSM. Participantes: Pacientes diabéticos tipo 2 con dislipoproteinemia. Intervenciones: Se ingresó al estudio a 48 pacientes diabéticos tipo 2 con dislipoproteinemia, de ambos géneros, de 40 a 70 años de edad, sin obesidad mórbida. Mediante una lista aleatoria, 15 recibieron simvastatina 20 mg + aceite placebo (grupo 1) y 14 aceite de sacha inchi + 1 comprimido placebo (grupo 2), durante 4 meses. En ayunas, se midió colesterol total (CT), colesterol HDL (HDL), triglicéridos (Tg), glucosa (G) y hemoglobina glicosilada (HbA1c), por métodos enzimáticos convencionales. Principales medidas de resultados: VLDL y LDL y colesterol no-HDL. Resultados: En el análisis...

Objetivos: Validar 3 instrumentos de evaluación de procesos de capacitación sobre violencia. Diseño: Análisis descriptivo, observacional, prospectivo del desempeño laboral de participantes posterior a su capacitación. Institución: El Programa Permanente de Capacitación para la Atención Integral de Víctimas de Violencia, Facultad de Medicina, UNMSM, impartió la Diplomatura de Atención Integral en Salud a Víctimas de Violencia y el Curso TOT. Participantes: Profesionales de salud y profesores universitarios de 12 regiones del país. Intervenciones: 70 profesionales de salud y profesores universitarios de 12 regiones del país recibieron ambas capacitaciones. Para evaluar el efecto de dicha capacitación, se elaboró 3 instrumentos: a) Cuestionario de Seguimiento a Ex alumnos, validado por grupos focales; permitió recabar información personal, laboral, de acciones prestaciona...

The San Marcos was founded shortly after the beginning of the conquest of Peru, in an environment characterized by irrepressible ambition for wealth of the conquerors and of the trustees, together with exploitation, abuse and merciless death of native heirs of the Inca Empire, by his pure inhuman dye moved to a religious group to denounce these facts and raise the cultural status of Spaniards, Creoles, mestizos and Indians. The work of Bartolomé de las Casas, who, moved by a judgment of wisdom Ecclesiastes-book of the Old Testament that says "he who offers sacrifice of the property of the poor is like the one slaughters a child before It is well known the father ... "- donated their property in an act of humanitarian release.

Was performed in 30 patients, a clinical study of the therapeutic and pharmacological effects of the fluocortolone ( Ultralan - ( R ) 1) , novel synthetic steroid derived from corticosterone . As adjunctive treatment of tuberculostatic drugs was administered to 18 patients with different clinical forms of tuberculosis (pleurisy with effusion , meningitis , miliary seeding) , in 6 patients with hypersensitivity reactions , 2 with systemic lupus erythematosus, one with dermotomiositis and 3 with leukemia . It has been seen that fluocortolone possesses a good anti- inflammatory effect with a relatively low potential to cause the appearance of secondary maniIestaciones . On the second day of administration, determinations and 17 - 0HS urinary 17 -KS showed that a single morning dose of 30 mgms . , Fluocortolone has a suppressive effect of somewhat less than 2 mgms adrenal function . dexameth...

174 people studied , 91 were normal controls, 55 nephropathy with renal insufficiency ( CIR ) and 28 without renal failure ( SIR) . The standard test of glucose tolerance (TST ) in 102 , being a definite intolerance in nephropathy , which was greater in the CIR group was performed . The differences between the 3 groups were statistically significant from 90 minutes. The tolbutamide test ( TT ) conducted in 83 subjects showed a decrease with poor resilience in response nephropathy . The curves allow differentiation found curves diabetics. Tolbutamide index also allowed differentiation between the 3 groups . The glucagon test (TG ) conducted in 20 subjects suggests the existence of a normal glycogenolysis in nephropathy , which showed a hyperglycemic response than controls. Relationship between the magnitude of serum creatinine of nephropathy with the degree of abnormality of test glucose ...

We used the fluocortolono, synthetic derivative of corticosterone in a single morning dose adjunctive corticosteroid medication along with TB treatment in 12 patients with pleurisy serofibrinous, 4 with meningitis and 2 with miliary tuberculous sow: combination therapy allowed rapid remission of inflammatory exudative component of the symptomatology, radiological abnormalities and decreased length of hospitalization. The aforementioned steroid has a good anti-inflammatory effect with lower potential to produce Cushing syndrome compared to other similar synthetic corticosteroids. The rare and little heavy to use under the scheme employed secondary manifestations not determined the dose reduction and even less treatment discontinuation.

Objetive. To study the frequency and characteristics of an obese population with and without cardiometabolic risk (CMR) and, to revise the concept of cardiometabolically healthy obese CMHO subjects. Material and methods. A total of 105 obese subjects, 30 to 75 years old, were recluted from a preventive-promotional program from may 2015 to april 2016. Previous informed consent, age, gender, anthropometric measures, blood pressure (BP), personal and family history of cardiovascular risk factors (CVRF) were registered. At fasting glucose (G), total cholesterol (TC), HDL cholesterol (cHDL), triglycerides (Tg), creatinine, plasma proteins, bilirrubins, transaminases (AST,ALT), alkaline fosfatase (FA) and gamaglutamyltranspeptidase (GGTP) were measured in blood by conventional methods. VLDL, LDL, Non-HDL fractions were calculated. Statistics were calculated with SPSS.23 program. Results. 77,4%...

Introduction. The therapeutic support of the metabolic control of diabetes mellitus type 2 (DM2) are the diet and physical activity.Objetive: To study the effect of a short and casual exercise on the basal and postprandial intermediary metabolism of individuals with DM2. Methods. A total of 16 female and 15 male, DM2 patients, 40 to 68 years old, were included in a experimental, tranversal study. They were submitted to a basal (A) and post-exercise (B) tests, the last one consisting in 30 minutes walking at 4 Km/hour on a treadmill, Under fasting, state, glucose, total cholesterol , HDL cholesterol, triglycerides, insulin and non-sterified fatty acids (NEFA) were measured in blood. Cholesterol VLDL, LDL, Non-HDL and HOMA were calculated. After a breakfast consisting in 55,5% fat, 37,2 % carbohydrates, 7,34% proteins containing 730 Kcal, glucose, insulin...

Objectives: To study basal and postprandial intermediary metabolism in normal postmenopausal high-altitude female dwellers, adapted to an environment characterized by low barometric and oxygen pressures and hypoxia. Methodology: An experimental study with control group was conducted; 20 normal high-altitude female dwellers –HAD- (Cusco, Peru, 3 395 meters above sea level-m.a.s.l.) and 16 normal sea level female dwellers –SLD- (Lima, Peru, 150 m.a.s.l.), 40 to 70 years old, postmenopausal, were included. Fasting glucose (G), total cholesterol (TC), HDL, triglycerides (Tg), insulin (I) and non-esterified fatty acids (NEFA) were measured in blood by conventional methods, and VLDL, LDL, non-HDL and HOMA were calculated. G, I, Tg, and NEFA were determined for 6 hours following the ingestion of a mixed meal containing 730 Kcal. Results: At fasting, the HAD had lower G and higher NEFA value...

Objective: To determine the frequency of cardiovascular risk factors (CVRF) in obese menopausal and premenopausal women aged 30 to 75 from Metropolitan Lima, Peru. Methods: We conducted a descriptive, analytical, transversal study in 95 obese women aged 30 to 75 from Metropolitan Lima from 2015 to 2017, where 48 were menopausal (MENO) and 47, premenopausal (PREMENO). Obesity grade was determined using the World Health Organization criteria. Conventional methods were used for anthropometry, blood pressure (BP), fasting blood glucose (G), total cholesterol (TC), triglycerides, HDL cholesterol, insulin (I) and transaminases values; VLDL, LDL and non-HDL (cNoHDL), and HOMA coefficient were calculated. We used the program SPSS v. 23 for statistical analysis. We considered obesity, dyslipoproteinemia, high blood pressure, insulin resistance and high transaminases values as CVRF. Results: From ...

Hormonal variations that characterize the normal menstrual cycle, noting that depends on adequate hypothalamic-pituitary-ovarian interaction are reviewed. He realizes the daily changes of the gonadotropins, estrogens and progesterone, as measured by radioimmunoassay blood analysis, gained over 7 normal menstrual cycles. It was found that the concentrations of FSH and LH are slightly higher in the follicular phase than in the luteal, displaying all mesocíclica them a matching rise in the ovulatory phase of both LH and FSH. Estradiol showed a significant elevation pre-ovulatory surge of gonadotropins and another in the luteal phase. Progesterone remained at a low level during the follicular phase increase substantially since the onset of the ovulatory peak of gonadotropins. The meaning of these hormonal changes is discussed.

No escapa al conocimiento y observación de los médicos, las dificultades, cada vez mayores, para obtener información científica. Los costos de los libros y revistas, tanto de procedencia extranjera como nacional, se han elevado por encima de las posibilidades de una adquisición periódica. 

No escapa al conocimiento y observación de los médicos, las dificultades, cada vez mayores, para obtener información científica. Los costos de los libros y revistas, tanto de procedencia extranjera como nacional, se han elevado por encima de las posibilidades de una adquisición periódica. 

Objective: To study and to compare the basal and postprandial intermediary metabolism of patients with diabetes mellitus type 2 (DM2) both at sea level (SL) as well as at high altitude (HA). Methodology: a total of 33 normal dwellers and 33 DM2 patients of SL(Lima, 150 meters above sea level- masl-) and 30 normal dwellers and 28 DM2 patients of HA(Cusco, 3,395 masl), of both genders, 40 to 70 years old were included. Body mass index (BMI) and abdominal circunference (AC) were measured. Glucose (G), total cholesterol (TC), HDL cholesterol (HDL), triglycerides (Tg), insulin (I) and non-esterified fatty acids (NEFA) were measured in blood at fasting, Cholesterol VLDL,LDL, NOHDL and HOMA coefficient were calculated; thereafter and during 6 hours after ingestion of a standardized mixed meal containing 730 Kcal G, I, Tg and NEFA were measured in blood. Statistical calculations were done by mea...

Objectives: To compare the hypolipemic effect of Sacha Inchi/galactomannan´s emulsion (SIE) with Simvastatin (SVT) in diabetics type 2 (DM2) with dislipoproteinemia. Methodology: A doble- blind, randomized, comparative-controlled study was performed. A total of 41 DM2 patients with dislipoproteinemia, both genders, 40 to 70 years old were included. At random, group 1 received SVT 20 mg + placebo emulsion (n=20) and group 2 received 10 ml SIE (sacha inchi, Plukenetia huayllabambana variety, conteining 2g omega-3 fatty acids + 0.03 g de galactomannans from de Tara gum, Caesalpinia spinosa ) + placebo pill (n=21) during 4 months. At fasting total cholesterol (TC), HDL cholesterol (cHDL), triglycerides (Tg), glucose (G), glicosilated hemoglobin (HbA1c), creatinine, trasaminases and TSH were measured by conventional methods, insulin by immunoluminiscence at the begining and every month ...

OBJECTIVE: To determine the prevalence and risk factors associated to diabetes-related lower limb amputations. MATERIAL AND METHODS: A descriptive, retrospective, longitudinal study, assessing the foots’ survival among 206 inpatients with diabetic foot at Hospital Nacional Dos de Mayo, between 1989 and 1997. RESULTS: Mean age was 61,4 years (range 27-86). Most of patients had tipe II diabetes mellitus (96,21%). Wagner’s classification of diabetic foot lesions was used to stratify the cases. Grades II - III in 35,92% and IV - V in 64,08% of patients were seen. 126 patients underwent amputation (61,16%), and 13 a reamputation (10%) of the lower limb. The main risk factors related to amputations were neuropathies (85,71%) and vasculopathy (71,43%). Mean age of amputation was 65,8 years. Two-months accumulated foot survival rate was 29% and amputation rate was 4%; whereas these were 16% ...

We have investigated the effect of Fursemida on glucose tolerance in 82 patients : 14 mormales , 15 cirrhotic , 15 diabetics, 7 patients with cardioesclerosis , 8 with hypertension , 8 nephropathy without failure and 15 with failure, for which administered daily 80 me . diuretic for one week. In 8 patients (4 diabetic , cirrhotic March 1 with hypertension ) occurred a pathological increase in basal glycemia. Except with nephropathy , elevated in all groups glycemia curves was observed , which was not significant in normal , diabetic , and cirrhosis . In cardiac patients the increase was noticeable but not statistically significant . In the hypertensive group the appearance of a greater number of abnormal curves was observed, mean difference at 90 ' and 120' was statistically significant. Patients with renal failure, most of whom had abnormal tolerances , showed declines and even normaliz...

Se estudió el efecto de la hidroclorotiazida sobre la curva de tolerancia de la glucosa, para cuyo efecto se administró diariamente 200 mq, de hidroclorotiazida durante 7 días a 53 sujetos: 10 presuntos normales, 20 con hipertensión esenciaL 7 con nefropatías difusas e insuficiencia renal, 6 nefrópatas sin insuficiencia renal y 10 con diabetes mellitus de moderada intensidad. No se produjo elevación de la glucosa sanguínea basal, en cambio sí hubo un incremento en las curvas de glicemia en todos los grupos a excepción de los nefrópatas. En los pacientes renales sin insuficiencia no se halló una variación importante, pero en los que acusaron retención nitrogenada la curva descendió. Los sujetos normales mostraron una elevación estadísticamente significativa a los 60 y 90 minutos, pero que no llegó a sobrepasar los límites normales. En los pacientes con hipertensión se ...