Disorders of carbohydrate metabolism in Carbon nephropathy

• Autores: Garmendia, Fausto, Rojas, M. Isabel, Valdivia, Héctor, Lorena, Braulio, García, Roberto
• Formato: artículo
• Fecha de Publicación: 1969
• Institución: Universidad Nacional Mayor de San Marcos
• Repositorio: Revistas - Universidad Nacional Mayor de San Marcos
• Lenguaje: español
• OAI Identifier: oai:ojs.csi.unmsm:article/5118
• Enlace del recurso: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/5118
• Nivel de acceso: acceso abierto

174 people studied , 91 were normal controls, 55 nephropathy with renal insufficiency ( CIR ) and 28 without renal failure ( SIR) . The standard test of glucose tolerance (TST ) in 102 , being a definite intolerance in nephropathy , which was greater in the CIR group was performed . The differences between the 3 groups were statistically significant from 90 minutes. The tolbutamide test ( TT ) conducted in 83 subjects showed a decrease with poor resilience in response nephropathy . The curves allow differentiation found curves diabetics. Tolbutamide index also allowed differentiation between the 3 groups . The glucagon test (TG ) conducted in 20 subjects suggests the existence of a normal glycogenolysis in nephropathy , which showed a hyperglycemic response than controls. Relationship between the magnitude of serum creatinine of nephropathy with the degree of abnormality of test glucose tolerance , expressed in terms of glycemia of 2 hrs was observed . , Not the test of tolbutamide or the test of glucagon. Mechanisms are likely to explain the changes found are discussed , which favor the idea that there is less use of glucose to peripheral cellular level , highlighting the importance of intracellular electrolyte disturbances as the most intriguing mechanism.