The design and planning of prevention and control interventions as well as the evaluation of interventions already implemented require a situational analysis based on various systems and sources of information that allow directing and prioritizing resources to the most vulnerable and / or disadvantaged populations. Health situation analyzes constitute a powerful tool for the identification of needs and priorities, being essential for the construction of health policies. On December 27, 2019, the National Center for Epidemiology, Disease Prevention and Control presented in the Paraninfo of the Ministry of Health the "Analysis of the situation of cancer in Peru, 2018". This technical document seeks to contribute based on the analysis of data from various sources of information to the design of cancer prevention and control interventions in the country, particularly in the formulation of th...

El diseño y planificación de las intervenciones de prevención y control así como la evaluación de las intervenciones ya implementadas requieren un análisis situacional a partir de diversos sistemas y fuentes de información que permitan dirigir y priorizar los recursos hacia las poblaciones más vulnerables y/o desfavorecidas. Los análisis de situación de salud constituyen una herramienta poderosa para la identificación de necesidades y prioridades siendo esenciales para la construcción de políticas en salud. El 27 de diciembre de 2019, el Centro Nacional de Epidemiología, Prevención y Control de Enfermedadespresentó en el Paraninfo del Ministerio de Salud el “Análisis de la situación del cáncer en el Perú, 2018”. Dicho documento técnico busca contribuir en base al análisis de datos de diversas fuentes de información al diseño de las intervenciones de prevenció...

Introduction: endemic pemphigus foliaceus (PFE) has been described at the beginning of the 50s in the peruvian forest. In 2006,Ortega & col. reported the presence of desmoglein 1 antibodies in Pueblo Libre, Ucayali. Nevertheless, immune reports does not exist on patients’ relatives with PFE in the zone.Objetives: to compare the immunopathologic profiles of healthy subjects from Pueblo Libre (an area in Ucayali, endemic for pemphigus foliaceus), with healthy relatives of patients with endemic pemphigus foliaceus (EPF) and healthy controls from non-endemic areas.Materials and methods: this is a prospective multicentric study performed from June to August 2006. The sample consisted of 41 healthy subjects from the Pueblo Libre community, 11 relatives of EPF patients and 20 healthy subjects from non-endemic areas. Blood samples were obtained for immunopathologic studies (E...

Introduction: endemic pemphigus foliaceus (PFE) has been described at the beginning of the 50s in the peruvian forest. In 2006,Ortega & col. reported the presence of desmoglein 1 antibodies in Pueblo Libre, Ucayali. Nevertheless, immune reports does not exist on patients’ relatives with PFE in the zone.Objetives: to compare the immunopathologic profiles of healthy subjects from Pueblo Libre (an area in Ucayali, endemic for pemphigus foliaceus), with healthy relatives of patients with endemic pemphigus foliaceus (EPF) and healthy controls from non-endemic areas.Materials and methods: this is a prospective multicentric study performed from June to August 2006. The sample consisted of 41 healthy subjects from the Pueblo Libre community, 11 relatives of EPF patients and 20 healthy subjects from non-endemic areas. Blood samples were obtained for immunopathologic studies (E...

La investigación titulada “Análisis de la prisión preventiva en la legislación del Perú, 2020”, se realizó con la finalidad de analizar la configuración de la prisión preventiva en la legislación del Perú. Se consideró como aspectos metodológicos, diseño no experimental, tipo transversal, descriptivo y univariable; para recoger los datos se empleó la técnica de observación, y el instrumento de ficha de observación respecto a la normativa de carácter constitucional, legal adjetivo y sustantivo, además de pronunciamientos de menor rango y jurisprudencia, en el que se consideró la escala de Likert, y su validez por expertos. Los datos fueron procesados mediante la estadística descriptiva e inferencial, la hipótesis de estudio fue corroborada mediante el estadígrafo t de student, donde se evidenció que, la configuración de la prisión preventiva es medianamente a...

El presente estudio tuvo como objetivo “Determinar las oportunidades de control interno que mejoren las posibilidades en la Empresa de Servicios Edificaciones y Soluciones A&L Empresa Individual de Responsabilidad Limitada, de la ciudad de Sullana en el año 2019. Para su desarrollo se utilizó la metodología de investigación de tipo de cuantitativa, de nivel descriptivo – no experimental, de diseño transversal. En la recolección de datos se aplicó como técnica: la entrevista, y como instrumentos de investigación: la ficha de entrevista y la lista de verificación. La población estuvo conformada por los trabajadores de la Empresa de Servicios Edificaciones y Soluciones A&L Empresa Individual de Responsabilidad Limitada, tomándose como muestra a los 03 jefes de las siguientes áreas: Almacén, Recursos Humanos, y Caja, y el Contador externo (trabajador independiente). Obteni�...

El presente trabajo de investigación tuvo como propósito determinar la manera en que la energía undimotriz influye en la mejora del suministro de electricidad en las viviendas del distrito de Pachacútec, Ventanilla-Perú . La metodología que se aplicó fue aplicada de nivel descriptivo-causal y con un diseño no experimental-longitudinal. Asimismo, la muestra se enfocó en 4 casas ubicadas en la playa de Bahía Blanca ubicada en la ciudad de Pachacútec – Ventanilla. Por otro lado, la técnica que se utilizó para la recolección de datos fue la encuesta empleada con un cuestionario como instrumento. De los resultados se obtuvo que la energía undimotriz influye significativamente en la mejora del costo de la electricidad producida en las viviendas del distrito de Pachacútec, Ventanilla-Perú. Para la evaluación del impacto de la implementación de energía undimotriz en el sumi...

On January 30, 2020, with more than 9,700 confirmed cases in China, the World Health Organization declared the coronavirus outbreak to be a public health emergency of international concern. At the end of January, the National Center for Epidemiology, Prevention and Control of Diseases (CDC-Peru) of the Ministry of Health prepared the “National Plan of Preparation and Response to the Introduction of the coronavirus 2019-nCoV”, where one of the strategic components was strengthen the epidemiological response through mitigation actions that allow early identification of cases, diagnosis, follow-up of contacts and identification of people with risk conditions.

Objective: To establish the effect of fresh maca (Lepidum meyenil walp) on the sportsmen physical performance at high altitude. Design: Comparative, prospective, and experimental study. Materials and Methods: Ten high altitude sportsmen constituted the sample. We first measured the maximum oxygen consumption under physical activity. Then they received 1500 mg of fresh maca daily during 60 days and a second evaluation was performed under similar conditions. The maximum oxygen intake and performance were determined and subjects were monitored for a 30 days period. Dosage of transaminases ALAT, ASAT, and serum creatinine were done during each evaluation. Results: In basal conditions the velocity average in the treadmill was 15,46 km/h and the maximum oxygen intake average was 52,32 mL/kg/min. In the second evaluation following the fresh maca consume the average of the maximum velocity raise...

On January 30, 2020, with more than 9,700 confirmed cases in China, the World Health Organization declared the coronavirus outbreak to be a public health emergency of international concern. At the end of January, the National Center for Epidemiology, Prevention and Control of Diseases (CDC-Peru) of the Ministry of Health prepared the “National Plan of Preparation and Response to the Introduction of the coronavirus 2019-nCoV”, where one of the strategic components was strengthen the epidemiological response through mitigation actions that allow early identification of cases, diagnosis, follow-up of contacts and identification of people with risk conditions.

Introduction. The COVID-19 emergency caused a pandemic with a great impact on mortality in Peru. Objective. To analyze the magnitude of mortality due to COVID-19 and identify some sociodemographic characteristics. Methods. A descriptive ecological study was carried out, analyzing data on deaths due to COVID-19 during the period 2020-2023, as well as publicly accessible socioeconomic and demographic indicators. The variables included in the study were: year of death, number of deaths, sex, age group, province of origin, natural region, macroregion, human development index (HDI), unmet basic needs (UBN) and population density. Results. 220,628 deaths due to COVID-19 were reported, of which 219,374 (99.43%) occurred during the pandemic and 1,254 (0.57%) in the post-pandemic period; The cumulative mortality rate was 6.76 deaths/1000 inhabitants. The COVID-19 death curve shows that between 20...

Background: Previous studies have shown oxidative stress in pemphigus vulgaris and pemphigus foliaceus, nevertheless, it remains unknown whether a similar response is characteristic of endemic pemphigus foliaceus in Peru. Objectives: To determine the oxidative stress response in endemic pemphigus foliaceus patients and subjects with positive for anti-desmoglein1 antibodies (anti-dsg1) from endemic areas of Peru. Subjects and Methods: This is a cross-sectional study. The study population included 21 patients with Endemic Pemphigus foliaceus and 12 healthy subjects with anti-dsg1 antibodies from the Peruvian Amazon (Ucayali), as well as 30 healthy control subjects. Malondialdehyde, an indicator of lipid peroxidation by free radicals, was measured in serum. Results: We collected 21 cases of endemic pemphigus foliaceus, 15 of them with active chronic disease and 6 in clinical remission. Seru...

Scientific research has always played a fundamental role in promoting health and the progress of society as a whole. A recent editorial published in The Lancet has discussed plausible research scenarios and outlined a vision of the future in which research could be an instrument for an "equitable and sustainable world with better health for all".

El Pénfigo Foliáceo Endémico (PFE) es una enfermedad autoinmune de la piel endémica en áreas de la Amazonía. Se revisa el caso de una mujer de 36 años que presentó PFE en la semana 17 de embarazo. A las 29 semanas, comenzó un tratamiento antimicrobiano y esteroides. En el momento del parto la enfermedad en la madre ya había sido controlada con corticoterapia, mostrando inmunofluorescencia indirecta (IFI) para IgG total negativa. De esta manera no habría descarga de anticuerpos hacia la placenta, y la recién nacida también mostró títulos negativos. Durante el seguimiento la niña varió sus títulos de anticuerpos, de negativo a 1/20. Recientemente se demostró que 45% de familiares de pacientes con PFE presentan anticuerpos anti Dsg-1, siendo más frecuente en familiares de primer grado.

Objective: To evaluate the feasibility of the methodological proposal to estimate the incidence and mortality due to cancer attributable to modifiable risk factors for Peru and Latin America. Methods: Pilot study, ecological from secondary sources. Modifiable risk factors, exposure prevalence, relative risks of these factors (RR) or an approximation by means of possibilities ratio (OR) were searched and selected. The information was recorded in a data collection form which was validated by expert judgment. For the calculation of the Population Attributable Fraction (FAP), the formula proposed by Parkin was tested and a statistical simulation model was developed with R. Studio V. 3.6.1 software. Results: In Peru there are prevalence studies for the majority of modifiable risk factors; Likewise, studies with OR estimates for several of the factors are available in Latin America; however, s...

Objectives: To determine the effectiveness of Peruvian purple corn (Zea mays) administration in serum lipids levels reduction (hypolipidemic effect) in non hypertensive diabetic patients with dyslipidemia; to compare hypolipidemic effect of Peruvian purple corn and simvastatin. Design: Clinical essay. Setting: Instituto de Investigaciones Clinicas, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Peru. Participants: Non hypertensive dyslipidemic diabetic patients. Interventions: Between January and October 2006 two groups of 15 non hypertensive dyslipidemic diabetic patients were randomly formed, patients with recent diagnosis, without previous treatment and without chronic complications; one group recieved simvastatin 40 mg/day and the other group Peruvian purple corn (dehydrated and micropulverized pills 1g/day) for 30 days. Patients had low fat diet with weekly nu...

Objetive: To determine efficacy and safety of capsaicin 0,075% topical therapy in the treatment of pruritus due to eosinophilic folliculitis in HIV patients with lymphocyte count CD4 (+) <250 x mm3. Design: Randomized clinical trial, double blind study. Setting: Infectious and Tropical Diseases Service and Dermatology Service, Hospital Nacional Dos de Mayo, Lima, Peru. Participants: Patients with VIH-associated eosinophilic folliculitis. Interventions: Forty patients with HIV-associated eosinophilic folliculitis were randomly distributed in two groups: group 1 included 20 patients that received sample 1 and group 2, 20 patients that received sample 2. Patients received capsaicin 0,075% and menthol 1% treatments (marked as sample 1 and sample 2). Instructions on topical use each 6 hours were given to patients. Visits were programmed to evaluate efficacy and monitor adverse events by st...

Objetivo: Evaluar la factibilidad y validar de la propuesta metodológica para estimar la incidencia y mortalidad por cáncer atribuible a factores de riesgo modificables para el Perú y Latinoamérica. Métodos: Estudio piloto, ecológico a partir de fuentes secundarias. Se buscó y seleccionó los factores de riesgo modificables, prevalencia de exposicion, los riesgos relativos de dichos factores (RR) o una aproximación mediante la razón de posibilidades (OR). La información fue consignada en una ficha de recolección de datos la cual fue validada mediante juicio de expertos. Para el cálculo de la Fracción Atribuible Poblacional (FAP) se ensayó la fórmula planteada por Parkin y se desarrolló un modelo de simulación estadística con el software R. Studio V. 3.6.1. Resultados: En el Perú se cuenta con estudios de prevalencia para la mayoría de factores de riesgo modificables; ...

Introduction: Obesity and depression contribute to the global burden of economic cost, morbidity, and mortality. Nevertheless, not all people with obesity develop depression. Objective: To determine the factors associated with depressive symptoms among people aged 15 or older with obesity from the National Demographic and Family Health Survey (ENDES in Spanish 2019–2021). Methods: Cross-sectional analytical study. The outcome of interest was the presence of depressive symptoms, assessed using the Patient Health Questionnaire-9 (PHQ-9). Crude (cPR) and adjusted (aPR) prevalence ratios were estimated using GLM Poisson distribution with robust variance estimates. Results: The prevalence of depression symptoms was 6.97%. In the multivariate analysis, a statistically significant association was found between depressive symptoms and female sex (PRa: 2.59; 95% CI 1.95–3.43); mountain region...

“Background: The metabolically obese normal-weight (MONW) phenotype has been considered a risk factor for different chronic diseases, but its role in high blood pressure (HBP) is still unclear. The aim of the study is to determine if the MONW phenotype constitutes a risk factor for hypertension in Peruvian adults belonging to a 5-year cohort. Methods: This is a retrospective cohort study. A secondary analysis from the database of the PERU MIGRANT study was carried out from the MONW and non-MONW cohorts; after a 5-year follow-up, the appearance of HBP was evaluated in the subjects of both cohorts. To assess the strength and magnitude of the association, a Poisson regression model (crude and adjusted) with robust variance was used. The measure of association was the relative risk (RR). Results: The incidence of HBP was 11.30%. In the multivariable analysis, subjects with the MONW phenoty...