Objective: To determine efficacy and security of of Annona muricata L (guanábana) leaves ethanolic extract plus glibenclamide capsules in controlling glucose levels in type 2 diabetes mellitus patients compared to patients receiving with glibenclamide alone. Design: Randomized, double-blind, parallel-group controlled clinical trial. Setting: Internal Medicine service, Tingo María-EsSalud Hospital I, Huanuco city. Par ticipants: Type 2 diabetes mellitus patients. Interventions: Between May 2007 and September 2007 sixty 38 to 60 year-old patients were randomly assigned to 6 groups, 3 receiving capsules containing 180 mg of Annona muricata L leaves ethanolic extract plus glibenclamide 5 mg and 3 receiving glibenclamide 5 mg tablets only. Main outcome measurements: Reduction of glycemia. Results: There was reduction of glycemic levels, higher in those receiving guanabana plus glibenclamida...

Estudio clínico, aleatorio, grupo paralelo, doble ciego, realizado en el Servicio de Medicina Interna del Hospital I Tingo María, de EsSalud, en el Departamento de Huánuco, para determinar la eficacia y seguridad de cápsulas de extracto etanólico de hojas de Annona muricata L (guanábana) más glibenclamida, para un mejor control de los niveles de glicemia comparado con la administración de glibenclamida sola, en pacientes con diabetes mellitus tipo 2. Entre mayo y setiembre de 2007, 60 pacientes fueron asignados a 6 grupos de manera aleatoria; 3 grupos recibieron cápsulas conteniendo 180 mg de extracto etanólico de hojas de Annona muricata L. más 5 mg de glibenclamida, los otros 3 grupos continuaron solo con glibenclamida, y se evaluaron los niveles de glicemia. Se encontró disminución del nivel de glicemia, siendo mayor el efecto en aquellos que recibieron guanábana más gl...

Objective: To determine the influence of both the ethanolic extract and the methanolic fraction containing phenolic and flavonoids compounds of Bidens pilosa L whole plant on gastric cancer induced in rats with N-nitroso-N-methylurea (NMU). Design: Experimental. Setting: Instituto de Investigaciones ClínicasBioterio, Facultad de Medicina UNMSM. Biologic material: Holtzmann male albino rats. Interventions: Following Ferraz de Souza et al., 2002, we had a normal control group, a group with NMU and NMU groups plus treatments with ethanolic extract and methanolic fraction at 300 mg/kg doses. For statistical significance we considered p<0,05. Main outcome measures: Progresion of gastric neoplasia induced in rats. Results: Indicate dysplasia and initial stages of carcinoma in the rats stomachs, which was less evident in the animals with treatment, being better the group that received the m...