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artículo
Publicado 2007
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Perú es uno de los principales países mineros del mundo, productor mundial de plata, estaño, plomo, zinc, cobre, oro, bismuto y molibdeno, ocupando los puestos segundos a quinto en producción, y productor de metales de tierras raras como el telurio y el selenio (Tabla 1). El sector minero creció a una tasa media anual del 9,26% entre 1994 y 2005, mientras que la economía peruana creció a una tasa media anual del 4,51% durante el mismo periodo, representando la mitad de las exportaciones del país (Ministerio de Comercio Exterior, 2006). El cobre, el oro y el zinc fueron los principales minerales de exportación, con Southem Perú (2.210 millones de dólares; 12,5% de las exportaciones totales de Perú), Antimina (1.853 millones; 12. 5% de las exportaciones totales) y Antamina (1.670 millones de dólares; 981 millones) son las dos mayores mineras de cobre de Perú, y todos los 10 p...
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artículo
Publicado 2025
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En este trabajo estudiamos los recursos florales utilizados por algunos colibríes a través de observación directa, colecta botánica y registros fotográficos entre 2011 y 2023 en 89 localidades del departamento de Cajamarca, Perú. Reportamos la interacción de 21 especies de colibríes; tres de ellos endémicos donde destaca el Cometa de Vientre Gris (Taphrolesbia griseiventris) categorizado “En Peligro” (EN). Además, el Oreja-Violeta de Vientre Azul (Colibri coruscans) fue la especie que presentó la mayor cantidad de interacciones con diferentes especies de flora (20 sp.). Documentamos el uso de 79 especies de flora (59 nativas, 20 introducidas y 9 endémicas), en 54 géneros y 35 familias. La familia con más especies que interactuan con colibríes fue Lamiaceae. Las especies arbóreas y arbustivas con mayor número de visitas por colibríes fueron Delostoma integrifolium, T...
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artículo
Publicado 2021
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The main aim of this work was to evaluate the agronomic behavior and nutritional composition of ten varieties of improved pastures in the agroclimatic conditions of the Nuevo Olmal Annex in the Sonche district. For this, the experimental design of randomized complete blocks (DBCA) with 10 treatments and 3 blocks was used. The gramineous forage species studied were: Gramilla, ryegrass ecotype Cajamarquino, ryegrass tetraploid biannual Austral, ryegrass Hybrid Boxer, ryegrass tetraploid Magnum, Festulolium, Dactylis Glomerata Mammoth, ryegrass tetraploid annual Jumbo, Festuca Alta and ryegrass bi-annual tetraplioid Hercules. In our study, the variables studied were green forage yield per hectare, percentage of dry matter and nutritional content; the results of the analysis of variance indicated significant differences, (p < 0.05) for all the variables. The Bonferroni test at 5% determined ...
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ponencia
Publicado 2009
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Material presentado en el XII Congreso Peruano Geológico Chileno el 22-26 noviembre de 2009, Santiago, Chile
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artículo
Publicado 2025
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Bisphenol A (BPA) is a widely used xenoestrogen that can disrupt neuroendocrine and immune regulation through multiple hormone receptors. This study investigated BPAinduced long non-coding RNA (lncRNA)-mRNA interactions in the cerebral cortex and hypothalamic-pituitary-thyroid (HPT) axis of adult male mice. Transcriptome sequencing and comprehensive lncRNA annotation identified 14,858 novel lncRNA transcripts. Integrated network analysis using weighted gene co-expression network analysis (WGCNA) revealed four distinct tissue-specific modules: neuronal signaling alterations (Tac1, Htr1b, Npy), RNA splicing modifications (Srsf5), PI3K/Akt-mediated cellular dysfunction (Creb5, Cdkn1a), and immune receptor signaling disruptions (Trbv15, Fcrla). These findings suggest that BPA reprograms transcriptional networks in a tissue-specific manner, potentially disrupting hormone-related neurotransmis...
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artículo
Publicado 2023
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Introduction: Acute lymphoblastic Leukemia (ALL) is the most common pediatric malignancy. While the survival rate for childhood ALL exceeds 90% in high-income countries, the estimated survival in low-and middle-income countries ranges from 22-79%, depending on the region and local resources. Methods: This study retrospectively reviewed demographic, biological, and clinical parameters of children under 18 years of age with newly diagnosed ALL presenting between 2013-2017 across five pediatric centers in 4 countries in South America. Survival analyses were estimated using the Kaplan-Meier method. Results: Across the five centers, 752 patients were analyzed (Bolivia [N=9], Ecuador [N=221], Paraguay [N=197], Peru [N=325]) and 92.1% (n=690) patients were diagnosed with B-cell and 7.5% (n= 56) with T-cell ALL. The median age was 5.5 years old (IQR 7.29). At diagnosis, 47.8% of patients were ca...
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artículo
Publicado 2023
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Background: In the KEYNOTE-826 study, the addition of the anti-PD-1 monoclonal antibody pembrolizumab to chemotherapy with or without bevacizumab improved overall survival and progression-free survival (primary endpoints) versus placebo plus chemotherapy with or without bevacizumab, with manageable toxicity, in patients with persistent, recurrent, or metastatic cervical cancer. In this Article, we report patient-reported outcomes (PROs) from KEYNOTE-826. Methods: KEYNOTE-826 is a multicentre, randomised, phase 3 trial in 151 cancer treatment centres in 19 countries. Eligible patients were aged 18 years or older with persistent, recurrent, or metastatic cervical cancer not previously treated with systemic chemotherapy (previous radiosensitising chemotherapy was allowed) and not amenable to curative treatment and had an Eastern Cooperative Oncology Group performance status of 0 or 1. Patie...
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artículo
Publicado 2024
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Adult T-cell leukemia-lymphoma (ATLL) is an aggressive malignancy driven by human T-cell leukemia virus type 1 (HTLV-1). Although patients from the Western hemisphere (Afro-Caribbean and South American) face worse prognoses, our understanding of ATLL molecular drivers derives mostly from Japanese studies. We performed multi-omic analyses to elucidate the genomic landscape of ATLL in Western cohorts. Recurrent deletions and/or damaging mutations involving FOXO3, ANKRD11, DGKZ, and PTPN6 implicate these genes as potential tumor suppressors. RNA-sequencing, published functional data and in vitro assays support the roles of ANKRD11 and FOXO3 as regulators of T-cell proliferation and apoptosis in ATLL, respectively. Survival data suggest that ANKRD11 mutation may confer a worse prognosis. Japanese and Western cohorts, in addition to acute and lymphomatous subtypes, demonstrated distinct molec...
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artículo
Publicado 2014
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Se realizó un análisis exhaustivo, utilizando un mapeo fino denso, para identificar variantes robustas e independientes que predisponen el Lupus Eritematoso Sistémico (LES), para predecir y validar los efectos moleculares de los alelos de riesgo de LES a través de la bioinformática, modelización molecular, y ensayos in vitro. Se analizó una gran cohorte multiétnica para investigar a fondo la asociación lupus eritematoso sistémico-NCF2 en población étnica diversa y para identificar etnicidad específica y variantes causales robustas.
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artículo
Publicado 2013
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This work was supported by the Fermi National Accelerator Laboratory under United States Department of Energy (DOE) Office of High Energy Physics Contract No. DE-AC02-07CH11359 which included the MINERvA construction project. Construction support also was granted by the United States National Science Foundation (NSF) under Grant No. PHY-0619727 and by the University of Rochester. Support for participating scientists was provided by NSF and DOE (USA) by CAPES and CNPq (Brazil), by CoNaCyT (Mexico), by CONICYT (Chile), by CONCYTEC, DGI-PUCP, and IDI/IGI-UNI (Peru), by Latin American Center for Physics (CLAF) and by RAS and the Russian Ministry of Education and Science (Russia). We thank the MINOS Collaboration for use of its near detector data. Finally, we thank the staff of Fermilab for support of the beam line and detector.
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artículo
Publicado 2013
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This work was supported by the Fermi National Accelerator Laboratory under United States Department of Energy (DOE) Office of High Energy Physics Contract No. DE-AC02-07CH11359 which included the MINERvA construction project. Construction support also was granted by the United States National Science Foundatation (NSF) under Grant No. PHY-0619727 and by the University of Rochester. Support for participating scientists was provided by NSF and DOE (U.S.A.) by CAPES and CNPq (Brazil), by CoNaCyT (Mexico), by CONICYT (Chile), by CONCYTEC, DGI-PUCP, and IDI/IGI-UNI (Peru), by Latin American Center for Physics (CLAF), and by RAS and the Russian Ministry of Education and Science (Russia). We thank the MINOS Collaboration for use of its near detector data. Finally, we thank the staff of Fermilab for support of the beam line and the detector.
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artículo
Publicado 2016
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Introduction: The selection of a medical specialty has been associated with multiple factors, such as personal preferences, academic exposure, motivational factors and sociodemographic factors, such as gender. The number of women in the medical field has increased in recent years. In Latin America, we have not found any studies that explore this relationship. Objective: To determine whether there is an association between gender and the intention to choose a medical specialty in medical students from 11 countries in Latin America. Methods: Secondary analysis of the Collaborative Working Group for the Research of Human Resources for Health (Red-LIRHUS) data; a multi-country project of students in their first year and fifth year of study, from 63 medical schools in 11 Latin American countries. All students who referred intention to choose a certain medical specialty were considered as part...
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artículo
The skin is the largest organ of the body that protects it from the external environment. High- frequency ultra sound (HF-US) has been used to visualize the skin in depth and to diagnose some pathologies in dermatological applications. Quantitative ultrasound (QUS) includes several techniques that provide values of particular physical properties. In this thesis work, three QUS parameters are explained and used to characterize healthy skin through HF-US: attenuation coefficient slope (ACS), backscatter coefficient (BSC) and shear wave speed (SWS). They were estimated with the regularized spectral-log difference (RSLD) method, the reference phan- tom method, and the crawling wave sonoelastography method, respectively. All the three parameters were assessed in phantoms, ex vivo and in vivo skin. In calibrated phantoms, RSLD showed a reduc- tion of up to 93% of the standard deviation concern...
