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artículo

Retrospective analysis of outcomes for pediatric acute lymphoblastic leukemia in South American centers

Publicado por
Duffy, C, Graetz, DE, Lopez, AMZ, Carrillo, A.K, Job, G, Chen, Y, Devidas, M, Leon, SA, Bonzi, SA, Flores, PC, Torres, LE, Broncano, EH, Jaramillo, SJ, Zelada, MO, Novoa, RR, Samudio, A, Sanchez-Fernandez, G, Villanueva, E, Metzger, ML, Friedrich, P, Jeha, S

Publicado 2023

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Introduction: Acute lymphoblastic Leukemia (ALL) is the most common pediatric malignancy. While the survival rate for childhood ALL exceeds 90% in high-income countries, the estimated survival in low-and middle-income countries ranges from 22-79%, depending on the region and local resources. Methods: This study retrospectively reviewed demographic, biological, and clinical parameters of children under 18 years of age with newly diagnosed ALL presenting between 2013-2017 across five pediatric centers in 4 countries in South America. Survival analyses were estimated using the Kaplan-Meier method. Results: Across the five centers, 752 patients were analyzed (Bolivia [N=9], Ecuador [N=221], Paraguay [N=197], Peru [N=325]) and 92.1% (n=690) patients were diagnosed with B-cell and 7.5% (n= 56) with T-cell ALL. The median age was 5.5 years old (IQR 7.29). At diagnosis, 47.8% of patients were ca...

artículo

Effect of paediatric early warning systems (PEWS) implementation on clinical deterioration event mortality among children with cancer in resource-limited hospitals in Latin America...

Publicado por
Agulnik, A, Muniz-Talavera, H, Pham, LTD, Chen, Y, Carrillo, AK, Cárdenas-Aguirre, A, Gonzalez-Ruiz, A, Garza, M, Conde-Morelos-Zaragoza, TM, Soberanis-Vasquez, DJ, Méndez-Aceituno, A, Acuña-Aguirre, C, Alfonso-Carreras, Y, Alvarez-Arellano, SY, Andrade Sarmiento, LA, Batista, R, Blasco Arriaga, EE, Calderon, P, Chavez-Rios, M, Costa, ME, Díaz-Coronado, R, Fing-Soto, EA, Gomez-Garcia, WC, Herrera-Almanza, M, Juarez-Tobias MS, Leon-Lopez, EM, Lopez-Facundo, NA, Martinez-Soria, RA, Miller, K, Miralda-Mendez, ST, Mora-Robles, LN, Negroe-Ocampo, N.D.C, Noriega Acuña B, Osuna-Garcia, A, Pérez-Alvarado, CM, Pérez-Fermin, CK, Pineda-Urquilla, EE, Portilla-Figueroa, CA, Ríos-Lopez, LE, Rivera-Mijares, J, Soto-Chávez, V, Suarez-Soto, JI, Teixeira-Costa, J, Tejocote-Romero, I, Villanueva-Hoyos, EE, Villegas-Pacheco, M, Devidas, M, Rodriguez-Galindo, C

Publicado 2023

Enlace

Background: Paediatric early warning systems (PEWS) aid in the early identification of clinical deterioration events in children admitted to hospital. We aimed to investigate the effect of PEWS implementation on mortality due to clinical deterioration in children with cancer in 32 resource-limited hospitals across Latin America. Methods: Proyecto Escala de Valoración de Alerta Temprana (Proyecto EVAT) is a quality improvement collaborative to implement PEWS in hospitals providing childhood cancer care. In this prospective, multicentre cohort study, centres joining Proyecto EVAT and completing PEWS implementation between April 1, 2017, and May 31, 2021, prospectively tracked clinical deterioration events and monthly inpatient-days in children admitted to hospital with cancer. De-identified registry data reported between April 17, 2017, and Nov 30, 2021, from all hospitals were included i...