OBJECTIVES: To determine the clinicopathological features of patients with cutaneous melanoma, the role of Merckel cells in this tumour and diagnostic usefulness of celular markers. MATERIAL AND METHODS: Clinico-pathological correlation of 650 clinical records of patients with histopathological diagnosis of cutaneous melanoma was done. The Ag S100, HMB-45, cromogranin A, and p53 protein presence were assessed in 30 of these patients who also had pigmented benign skin lesions. RESULTS: Patients with melanoma had history of sunlight exposure and previous nevus or associated nevus. AgS100 was the more sensitive marker but had lesser specificity; HMB-45 was positive in lesions with malignant and active melanocytes whereas p53 was seen in certain melanoma cells. Proliferating Merckel cells were not found. CONCLUSIONS: S100 antigen must be used as diagnostic tool; HMB-45 had a lesser sensitivi...

Diffuse large B-cell lymphoma is a rare neoplasm of the central nervous system with aggressive behavior and poor outcome. CD5 expression in nodal or extranodal in this neoplasm is infrequent. These cases tend to be more aggressive than the CD5 negative cases. Herein, we report a case of primary brain CD5-positive diffuse large B-cell lymphoma presenting in an immunocompetent 64-year-old woman. She presented with intensity frontoparietal headache, nausea, vomiting, generalized seizures and confusional symptoms. Nuclear magnetic resonance showed characteristics of malignant lymphoma. The patient received treatment with corticoids with good response. Two years after the initial condition, she presented symptoms again. Brain images studies showed bifrontal neoplasm. No tumors were found in other sites. On the basis of morphology and immunohistochemistry, the diagnosis was CD5-positive diffus...

Objectives. The latest WHO classification of hematopoietic and lymphoid neoplasms considers 29 mature T and NK cell lymphomas. One of these corresponds to peripheral T-cell lymphoma, without another specification (LCTP-NOS). The objective of this research was to evaluate the clinical-pathological characteristics of this disease and its association with EBV infection in relation to global survival (OS). Methods. 65 cases with a diagnosis of LCTP-NOS were studied at the National Institute of Neoplastic Diseases in a period of 6 years. Clinical-pathological characteristics were evaluated, and OS and other clinical parameters were compared between cases with infection and without EBV infection. Results. There were (45 %) positive cases for EBV. The average age was 50 years and (29 %) were women. The proportion of patients with and without B symptoms was similar. The stages were usually advan...

Objectives. The latest WHO classification of hematopoietic and lymphoid neoplasms considers 29 mature T and NK cell lymphomas. One of these corresponds to peripheral T-cell lymphoma, without another specification (LCTP-NOS). The objective of this research was to evaluate the clinical-pathological characteristics of this disease and its association with EBV infection in relation to global survival (OS). Methods. 65 cases with a diagnosis of LCTP-NOS were studied at the National Institute of Neoplastic Diseases in a period of 6 years. Clinical-pathological characteristics were evaluated, and OS and other clinical parameters were compared between cases with infection and without EBV infection. Results. There were (45 %) positive cases for EBV. The average age was 50 years and (29 %) were women. The proportion of patients with and without B symptoms was similar. The stages were usually advan...

Diffuse large B-cell lymphoma is a rare neoplasm of the central nervous system with aggressive behavior and poor outcome. CD5 expression in nodal or extranodal in this neoplasm is infrequent. These cases tend to be more aggressive than the CD5 negative cases. Herein, we report a case of primary brain CD5-positive diffuse large B-cell lymphoma presenting in an immunocompetent 64-year-old woman. She presented with intensity frontoparietal headache, nausea, vomiting, generalized seizures and confusional symptoms. Nuclear magnetic resonance showed characteristics of malignant lymphoma. The patient received treatment with corticoids with good response. Two years after the initial condition, she presented symptoms again. Brain images studies showed bifrontal neoplasm. No tumors were found in other sites. On the basis of morphology and immunohistochemistry, the diagnosis was CD5-positive diffus...

El presente trabajo de investigación tuvo como objetivo principal analizar cómo y cuáles son las estrategias que se emplean para el proceso de enseñanza-aprendizaje en los oficiales estudiantes de los cursos que se desarrollaron en el Comando de Educación y Doctrina del Ejercito (Coede), durante el AF-2019 , para lo cual este estudio se ha basado en un enfoque cualitativo dentro del paradigma etimológico hermenéutico – interpretativo, utilizando como técnica la entrevista en oficiales estudiantes y docentes que se desempeñaron como tales, en el periodo antes mencionado y que actualmente se encuentran laborando en la guarnición de Lima, dentro del estudio realizado se tuvo como dificultad el acceso a la información clasificada dentro de la Jefatura de Educación del Ejército, la que se requirió para el análisis documental de la estructura curricular, para lo cual se oficiÃ...

El presente trabajo de investigación tuvo como objetivo principal analizar cómo y cuáles son las estrategias que se emplean para el proceso de enseñanza-aprendizaje en los oficiales estudiantes de los cursos que se desarrollaron en el Comando de Educación y Doctrina del Ejercito (Coede), durante el AF-2019 , para lo cual este estudio se ha basado en un enfoque cualitativo dentro del paradigma etimológico hermenéutico – interpretativo, utilizando como técnica la entrevista en oficiales estudiantes y docentes que se desempeñaron como tales, en el periodo antes mencionado y que actualmente se encuentran laborando en la guarnición de Lima, dentro del estudio realizado se tuvo como dificultad el acceso a la información clasificada dentro de la Jefatura de Educación del Ejército, la que se requirió para el análisis documental de la estructura curricular, para lo cual se oficiÃ...

The research presented was aimed to establishing market, technical, economic and financial viabiliity of implementing a craft beer manufacturing plant in Lima. This industry has develope with huge successl in countries with more developed beer culture as USA, Germany, Colombia or Chile. In Peru it is still in an embryonic stage.

El oligodendroglioma de la médula espinal es una neoplasia extremadamente rara y solo se han reportado 52 casos en la literatura. Se reporta el caso de un paciente varón de 52 años, con paraplejia y un tumor en la medula espinal a nivel de C7 a T4. El diagnóstico final fue oligodendroglioma anaplásico con deleción del cromosoma 1p.

El oligodendroglioma de la médula espinal es una neoplasia extremadamente rara y solo se han reportado 52 casos en la literatura. Se reporta el caso de un paciente varón de 52 años, con paraplejia y un tumor en la medula espinal a nivel de C7 a T4. El diagnóstico final fue oligodendroglioma anaplásico con deleción del cromosoma 1p.

OBJECTIVE: To assess the incidence, clinical–pathological and immunophenotypical characteristics of extranodal lymphomas (ENL) at Lima. MATERIAL AND METHODS: All cases with pathologic diagnosis of ENL done in 1998 in the Institute of Cancer, Social Security and Army general hospitals were studied. Data was obtained from medical records. Samples were reviewed by two pathologist using the REAL classification. RESULTS: 616 non-Hodgkin’s lymphomas (308 of them were extranodal), and 88 Hodgkin’s lymphomas were diagnosed. ENLs were predominantly gastric (70 cases), and cutaneous (49 cases). Mainly, lymphomas of the stomach, Waldeyer’s ring, intestine, and salivary glands showed B trait, and lymphomas of the skin an nasal pharynx showed T trait. The marginal zone MALT lymphomas were the commonest in the digestive tract. CONCLUSION: The higher frequency of ENL in the gastrointestinal tra...

Objective. To evaluate the sensitivity, specifcity and predictive values of theclinical cytological study of patients with ascites in a national general hospital in Peru. Methods. Patients presenting with clinical manifestations of ascites, biochemical, cytological and histological studies were included. Results. Fifteen patients with ascites were studied. The mean age was 62 years, being 80% female and 20% male. The fnal diagnoses revealed various malignant neoplasms (93.3%) and peritoneal tuberculosis (6.7%). The most frequent clinical manifestation was mild to severe abdominal pain (80%). The cellular components were: red blood cells (73.3%), histiocytes (26.7%), lymphocytes (73.3%), polymorphonuclear cells (40%), mesothelial cells (86.7%) and clusters of epithelioid cells with varying degrees of atypia (80%). Two casesshowed atypical lymphoid cells. The sensitivity and positive predi...

Objective. Present a theoretical support to take into account in the safe execution of the work in the laboratory of pathological anatomy during the COVID19 pandemic. Methods. We reviewed the relevant bibliographic material published by WHO, prestigious specialized international institutions and national ones on biosafety in this pandemic. Results. This document contains the biosafety theoretical framework for the execution of the various procedures in the laboratory of pathological anatomy in Peru, in this scenario of SARS-Cov2 pandemic. Conclusions. Knowledge about the COVID-19 pandemic and its causative agent constantly surprises the scientific community, it is the reason why its updating and its dissemination must be permanent

The ongoing COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global public health crisis. Many reports indicate disappointing results in cancer patients compared to the general population. Therefore, experts in the management of oncohematological malignancies from the National Institute of Neoplastic Diseases, national hospitals and a private clinic in Metropolitan Lima have developed recommendations obtained by consensus to continue with the management of patients with oncohematological neoplasms safely in the face of the pandemic.