Paciente de 30 años con epistaxis recurrente durante dos años. Posteriormente, notó la presencia de un tumor nasal izquierdo, alteración visual y obstrucción nasal en el mismo lado. La histopatología reveló un proceso expansivo de células pequeñas redondas azules en la fosa nasal izquierda; y, los estudios de inmunohistoquímica concluyó como sarcoma de Ewing/tumor neuroectodérmico primitivo. Se realizó en una maxilectomía medial parcial posterior izquierda, quimioterapia y radioterapia local.

Paciente varón de 60 años con epistaxis recurrente, obstrucción nasal, respiración bucal, dolor endonasal, cefalea frontal intermitente y deformidad nasal progresiva durante cuatro años. La histopatología reveló un infiltrado inflamatorio crónico con abundantes histiocitos que presentan el fenómeno de emperipolesis; y, la inmunohistoquímica confirmó el diagnóstico de enfermedad de Rosai-Dorfman extranodal. El paciente recibió quimioterapia metronómica y terapia inmunomoduladora, observándose una buena respuesta clínica luego de tres ciclos de tratamiento.

Paciente de 48 años que cursa con dolor abdominal asociado a perdida ponderal. En la endoscopía se evidencia una lesión una lesión infiltrativa ulcerada, friable y circunferencial que compromete el canal pilórico y bulbo duodenal Al estudio histopatológico se revela un adenocarcinoma tipo intestinal con área de diferenciación en coriocarcinoma. Se realizó una gastrectomía parcial distal y posteriormente quimioterapia dirigida a la estirpe del coriocarcinoma, con buena respuesta clínica al primer curso.

A 60-year-old male patient with recurrent epistaxis, nasal obstruction, oral breathing, endonasal pain, intermittent frontal headache and progressive nasal deformity for four years. Histopathology revealed a chronic inflammatory infiltrate with abundant histiocytes that present the phenomenon of emperipolesis; and, immunohistochemistry confirmed the diagnosis of extranodal Rosai-Dorfman disease. The patient received metronomic chemotherapy and immunomodulatory therapy, a good clinical response was observed after three cycles of treatment.

A 48 year-old patient with abdominal pain associated and weight loss is shown. Endoscopy shows an ulcerated, friable, circumferential infiltratory lesion that compromises the pyloric canal and duodenal bulb The histopathological study reveals intestinal type adenocarcinoma with area of differentiation in coriocarcinoma. A partial distal gastrectomy and subsequent chemotherapy were performed aimed at the lineage of the coriocarcinoma, with good clinical response to the first course.

A 30 year-old patient with recurrent epistaxis for two years, then noted a left nasal tumor, visual disturbance and nasal obstruction on the same side. The histopathology study reveals an expansive process of small round blue cells in the left nostril; and, the immunohistochemistry concluded as an Ewing's sarcoma/primary neuroectodermic tumor. It was carried out a left posterior medial maxillectomy, chemotherapy and local radiotherapy.

Introduction: Uterine leiomyosarcoma is a rare and highly aggressive sarcoma, which can metastasize most frequently to the lung and liver. Its prognosis is poor, with early total abdominal hysterectomy being the first line treatment. Other alternatives are chemotherapy with regimens of doxorubicin, ifosfamide or gemcitabine, alone or in combination. Case report: We present a 40-year-old Peruvian woman who underwent hysterectomy for suspected leiomyoma; however, pathology revealed a final diagnosis of uterine leiomyosarcoma. She could not be notified due to loss to follow-up. Two years later, she again presented with metastases in the thigh, breast, liver, lungs and scalp. He was given Ifosfamide and Doxorubicin every 21 days for 3 courses, however, due to disease progression, palliative treatment was decided. Finally, he died two months after treatment. Conclusion: A case of uterine leio...

Background: Breast cancer women have a tendency to develop psychiatric symptomatology, mainly depressive. A way to evaluate how the patient entails her disease is by quality of life. Objectives: To determine the prevalence of depressive symptoms and quality of life and their associations with time since diagnosis and the menopausal status. Design: Analytical, observational and transversal study. Setting: Arzobispo Loayza Hospital Oncology Service. Participants: Women with clinical and histological diagnosis of breast cancer and seeking chemotherapy. Interventions: The Beck depression inventory, the Mezzich and Cohen quality of life scale and a demographic questionnaire were used. The Fisher test, student’s T-test and lineal regression analysis were used. Main outcome measures: Depression symptoms, quality of life. Results: In 24 women studied the prevalence of depressive symptoms and l...

The ongoing COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global public health crisis. Many reports indicate disappointing results in cancer patients compared to the general population. Therefore, experts in the management of oncohematological malignancies from the National Institute of Neoplastic Diseases, national hospitals and a private clinic in Metropolitan Lima have developed recommendations obtained by consensus to continue with the management of patients with oncohematological neoplasms safely in the face of the pandemic.

Introduction. In Peru, breast cancer represents the most common type of cancer in women and the sixth most lethal type of cancer in the general population. Overexpression of the epidermal growth factor receptor (HER2 +) occurs in 20% to 30% of breast cancers, and is associated with more aggressive tumors, with greater recurrence and greater mortality. Objective. Prepare a set of evidence-based recommendations for the diagnosis and treatment of HER2 + breast cancer, in order to help reduce mortality, disease progression and improve quality of life. Methods. A panel of clinical specialists and methodologists was formed, who identified relevant clinical questions about the diagnosis and treatment of HER2 + breast cancer. A systematic search for CPGs was carried out in Medline (PubMed), and in developing and compiling agencies. For the formulation of recomm...