The aim of this work done at the Instituto de Patologia de la Facultad de Medicina-UNMSM was to know the frequency of secondary tuberculous glomerulonephritis, through a retrospective study of 42 autopsies and 3 post mortem biopsies in 45 tuberculous patients with glomerulonephritis. Mycobacterium antigens in renal glomeruli were identified by immunomicroscopy. The glomerular lesion was classified with the 1988 WHO classification of renal diseases. Clinical pathological correlation was done. We concluded : a) 37,78% of the cases in this study had Mycobacterium antigens positive in the glomeruli; b) In all the positive cases the glomerular lesion was classified as membranoproliferative or mesangiocapillary glomerulonephritis; c) Most of the patients with secondary mesangiocapillary glomerulonephritis had chronic pulmonary tuberculosis.

OBJECTIVES: To determine the clinicopathological features of patients with cutaneous melanoma, the role of Merckel cells in this tumour and diagnostic usefulness of celular markers. MATERIAL AND METHODS: Clinico-pathological correlation of 650 clinical records of patients with histopathological diagnosis of cutaneous melanoma was done. The Ag S100, HMB-45, cromogranin A, and p53 protein presence were assessed in 30 of these patients who also had pigmented benign skin lesions. RESULTS: Patients with melanoma had history of sunlight exposure and previous nevus or associated nevus. AgS100 was the more sensitive marker but had lesser specificity; HMB-45 was positive in lesions with malignant and active melanocytes whereas p53 was seen in certain melanoma cells. Proliferating Merckel cells were not found. CONCLUSIONS: S100 antigen must be used as diagnostic tool; HMB-45 had a lesser sensitivi...

We studied 51 patient from Lima and other peruvian districts with vitiligo, acquired idiopatic illness, that is due to gradual melanocyte destruction and immunological disturbances. The purposes were the early diagnosis of other associated autoimmune diseases and to do a clinic pathological correlation including family data. We studied circulating autoantibodies and skin biopsis in immunomicroscopy. Generalized vulgaris vitiligo was the most frequent type of vitiligo. The 33.3% of all the cases had other associated autoimmune disease and 37.2% hypersensitivity I disease. The 19.6% has family members with vitiligo and 31.2% with other autoimmune diseases.