We studied 51 patient from Lima and other peruvian districts with vitiligo, acquired idiopatic illness, that is due to gradual melanocyte destruction and immunological disturbances. The purposes were the early diagnosis of other associated autoimmune diseases and to do a clinic pathological correlation including family data. We studied circulating autoantibodies and skin biopsis in immunomicroscopy. Generalized vulgaris vitiligo was the most frequent type of vitiligo. The 33.3% of all the cases had other associated autoimmune disease and 37.2% hypersensitivity I disease. The 19.6% has family members with vitiligo and 31.2% with other autoimmune diseases.

OBJECTIVE: To show the clinicopathological features of non-neoplastic cutaneous lesions in women with HIV/AIDS. DESIGN: Descriptive retrospective study. MATERIAL AND METHODS: Biopsies of skin have been taken from 18 women with non–neoplastic cutaneous lesions, and submitted to histopathological and immuno–histochemical studies. RESULTS: Most women were in the age of 20-to-29 years (55,6%), or 30-to-39 years (22,2%), and catalogued as clinical stage B3 (33,3%), or C3 (27,8%). Dermatitis with fibrosis (50%), and granulomatous dermatitis (38,8%) were the commonest cutaneous lesions. We found Candida (44,4%), and Epstein Barr virus (22,2%) as well. CONCLUSIONS: Young women looking for medical care with AIDS indicators, and pruriginous cutaneous lesions, was the predominant picture. Dermatitis with fibrosis and evidence of Candida in cutaneous lesions has been the most frequent diagnosis.

OBJECTIVES: To establish the prevalence of Human Papillomavirus (HPV) in pre-malignant lesions and invasive cervical lesions, and to assess the sensitivity and specificity of inmunohisto- chemical method to detect HPV antigens with respect to the citologic, colposcopic and anatomopathologic studies. MATERIAL AND METHODS: Cervical biopsy samples were taken under colposcopy among 91 women from Lima, who had a previous abnormal cytologic control. Results of their citologic, colposcopic and biopsy samples, as well as immunohistochemical detection of viral antigens were recorded. RESULTS: HPV was diagnosed 39/91 (43%) by cytologic, 57/91 (63%) by colposcopic, and 78/91 (86%) by histologic methods. HPV antigen expression positivity was 53/91 (56%) by immunohistochemistry. High grade intraepiteliary scamous lesions (ISL) were more frequent than low grade ISL. CONCLUSIONS: Prevalence of HPV amon...

OBJECTIVES: To determine the clinicopathological features of patients with cutaneous melanoma, the role of Merckel cells in this tumour and diagnostic usefulness of celular markers. MATERIAL AND METHODS: Clinico-pathological correlation of 650 clinical records of patients with histopathological diagnosis of cutaneous melanoma was done. The Ag S100, HMB-45, cromogranin A, and p53 protein presence were assessed in 30 of these patients who also had pigmented benign skin lesions. RESULTS: Patients with melanoma had history of sunlight exposure and previous nevus or associated nevus. AgS100 was the more sensitive marker but had lesser specificity; HMB-45 was positive in lesions with malignant and active melanocytes whereas p53 was seen in certain melanoma cells. Proliferating Merckel cells were not found. CONCLUSIONS: S100 antigen must be used as diagnostic tool; HMB-45 had a lesser sensitivi...

OBJECTIVE: To assess the incidence, clinical–pathological and immunophenotypical characteristics of extranodal lymphomas (ENL) at Lima. MATERIAL AND METHODS: All cases with pathologic diagnosis of ENL done in 1998 in the Institute of Cancer, Social Security and Army general hospitals were studied. Data was obtained from medical records. Samples were reviewed by two pathologist using the REAL classification. RESULTS: 616 non-Hodgkin’s lymphomas (308 of them were extranodal), and 88 Hodgkin’s lymphomas were diagnosed. ENLs were predominantly gastric (70 cases), and cutaneous (49 cases). Mainly, lymphomas of the stomach, Waldeyer’s ring, intestine, and salivary glands showed B trait, and lymphomas of the skin an nasal pharynx showed T trait. The marginal zone MALT lymphomas were the commonest in the digestive tract. CONCLUSION: The higher frequency of ENL in the gastrointestinal tra...

The aim of this work done at the Instituto de Patologia de la Facultad de Medicina-UNMSM was to know the frequency of secondary tuberculous glomerulonephritis, through a retrospective study of 42 autopsies and 3 post mortem biopsies in 45 tuberculous patients with glomerulonephritis. Mycobacterium antigens in renal glomeruli were identified by immunomicroscopy. The glomerular lesion was classified with the 1988 WHO classification of renal diseases. Clinical pathological correlation was done. We concluded : a) 37,78% of the cases in this study had Mycobacterium antigens positive in the glomeruli; b) In all the positive cases the glomerular lesion was classified as membranoproliferative or mesangiocapillary glomerulonephritis; c) Most of the patients with secondary mesangiocapillary glomerulonephritis had chronic pulmonary tuberculosis.