1
artículo
Publicado 2019
Enlace
Enlace
Objectives. The latest WHO classification of hematopoietic and lymphoid neoplasms considers 29 mature T and NK cell lymphomas. One of these corresponds to peripheral T-cell lymphoma, without another specification (LCTP-NOS). The objective of this research was to evaluate the clinical-pathological characteristics of this disease and its association with EBV infection in relation to global survival (OS). Methods. 65 cases with a diagnosis of LCTP-NOS were studied at the National Institute of Neoplastic Diseases in a period of 6 years. Clinical-pathological characteristics were evaluated, and OS and other clinical parameters were compared between cases with infection and without EBV infection. Results. There were (45 %) positive cases for EBV. The average age was 50 years and (29 %) were women. The proportion of patients with and without B symptoms was similar. The stages were usually advan...
2
artículo
Publicado 2024
Enlace
Enlace
Introduction: Triple-negative breast cancer (TNBC) is notably an aggressive breast cancer (BC) subtype, leading to early relapse and poor prognosis. Effects of adjuvant chemotherapy among early-stage TNBC (pT1N0M0) patients remain unclear in different populations. Objectives: Our study aimed to determine the impact of adjuvant chemotherapy on overall survival (OS) and progression-free survival (PFS) within the specific subset of Peruvian pT1N0M0 TNBC patients (pT1a/b vs. pT1c). Methods: We retrospectively analyzed 2007 TNBC cases diagnosed between 2000-2014 at the Instituto Nacional de Enfermedades Neoplásicas (Lima, Peru). We included only non-metastatic TNBC cases and classified them as pT1N0M0 after surgery. TNBC patients who underwent neoadjuvant chemotherapy were excluded. We describe our population according to the tumor size from the residue disease (pT1a/b vs. pT1c). We used the...
3
artículo
Publicado 2020
Enlace
Enlace
We sought to review literature on the prevalence of symptoms of depression in women with a diagnosis of breast cancer (BC) and in the Peruvian population determine the prevalence of symptoms of depression and to describe the association with sociodemographic characteristics. Descriptive cross-sectional analytical study of 254 patients from the National Cancer Institute of Peru (Instituto Nacional de Enfermedades Neoplasicas) with a diagnosis of clinical stage I or II BC. The patients included women aged between 26 and 67 years old. Symptoms of depression were monitored by the Beck Depression Inventory-II. Moreover, clinical features and patient sociodemographic characteristics were analyzed and their association with depression was assessed by logistic regression. The average age of the patients was 47.8 +/- 9.2 years; 5.4% of the patients were postmenopausal at the time of the questionn...
4
artículo
Publicado 2022
Enlace
Enlace
Objective. The aim of this study was to determine the relationship between anemia and depressive symptoms in patients with early stage breast cancer at the National Institute of Neoplastic Diseases (INEN), Lima, Peru. Methods. An analytical cross-sectional observational study of 60 Peruvian women diagnosed with early stage I and II breast cancer was conducted between June 2019 and March 2020. All participants were assessed by Beck Depression Inventory-II (BDIII) score, had not received prior chemotherapy, and met the inclusion criteria. Each participant provided a blood sample that was used to estimate hemoglobin and red and white blood cell counts. Results. Of the 60 patients who met the inclusion criteria, twenty (33.3%) had depressive symptoms at the time of diagnosis. Mean hemoglobin levels in patients with depressive symptoms (M = 10.9, SD = 2.1) were lower compared to those in pa...
5
artículo
Publicado 2022
Enlace
Enlace
Background: Breast cancer incidence in the United States is lower in Hispanic/Latina (H/L) compared with African American/ Black or Non-Hispanic White women. An Indigenous American breast cancer-protective germline variant (rs140068132) has been reported near the estrogen receptor 1 gene. This study tests the association of rs140068132 and other polymorphisms in the 6q25 region with subtype-specific breast cancer risk in H/Ls of high Indigenous American ancestry. Methods: Genotypes were obtained for 5,094 Peruvian women with (1,755) and without (3,337) breast cancer. Associations between genotype and overall and subtype-specific risk for the protective variant were tested using logistic regression models and conditional analyses, including other risk-associated polymorphisms in the region. Results: We replicated the reported association between rs140068132 and breast cancer risk overall ...
