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artículo

Diagnóstico y tratamiento del cáncer de mama HER2+: Guía de Práctica Clínica de la Sociedad Peruana de Cancerología

Publicado por
Morante, Zaida D., Rebaza, Lia P., Castañeda, Carlos A., Luyo, Gustavo D., Neciosup, Silvia P., Vera, Luis A., Aliaga, Rolig A., Aliaga, Karina M., Cotrina, José M., Guerra, Rolando H., Fuentes, Hugo A., Malca, Jenny, Ballón, Karinthia, Fuentes Rivera, Paola, Negreiros, Tatiana, Mendoza, Zulma K., Hijar, Gisely, Aramburu, Adolfo, Gómez, Henry L.

Publicado 2021

Enlace

Introduction. In Peru, breast cancer represents the most common type of cancer in women and the sixth most lethal type of cancer in the general population. Overexpression of the epidermal growth factor receptor (HER2 +) occurs in 20% to 30% of breast cancers, and is associated with more aggressive tumors, with greater recurrence and greater mortality. Objective. Prepare a set of evidence-based recommendations for the diagnosis and treatment of HER2 + breast cancer, in order to help reduce mortality, disease progression and improve quality of life. Methods. A panel of clinical specialists and methodologists was formed, who identified relevant clinical questions about the diagnosis and treatment of HER2 + breast cancer. A systematic search for CPGs was carried out in Medline (PubMed), and in developing and compiling agencies. For the formulation of recomm...

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artículo

Association between Ancestry-Specific 6q25 Variants and Breast Cancer Subtypes in Peruvian Women

Publicado por
Zavala, Valentina A., Casavilca-Zambrano, Sandro, Navarro-Vásquez, Jeannie, Castañeda, Carlos A., Valencia, Guillermo, Morante, Zaida, Calderón, Monica, Abugattas, Julio E., Gómez, Henry, Fuentes, Hugo A., Liendo-Picoaga, Ruddy, Cotrina, Jose M., Monge, Claudia, Neciosup, Silvia P., Huntsman, Scott, Hu, Donglei, Sánchez, Sixto E., Williams, Michelle A., Núñez-Marrero, Angel, Godoy, Lenin, Hechmer, Aaron, Olshen, Adam B., Dutil, Julie, Ziv, Elad, Zabaleta, Jovanny, Gelaye, Bizu, Vásquez, Jule, Gálvez-Nino, Marco, Enriquez-Vera, Daniel, Vidaurre, Tatiana, Fejerman, Laura

Publicado 2022

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Background: Breast cancer incidence in the United States is lower in Hispanic/Latina (H/L) compared with African American/ Black or Non-Hispanic White women. An Indigenous American breast cancer-protective germline variant (rs140068132) has been reported near the estrogen receptor 1 gene. This study tests the association of rs140068132 and other polymorphisms in the 6q25 region with subtype-specific breast cancer risk in H/Ls of high Indigenous American ancestry. Methods: Genotypes were obtained for 5,094 Peruvian women with (1,755) and without (3,337) breast cancer. Associations between genotype and overall and subtype-specific risk for the protective variant were tested using logistic regression models and conditional analyses, including other risk-associated polymorphisms in the region. Results: We replicated the reported association between rs140068132 and breast cancer risk overall ...

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Supplemental Table S4 from Evaluation of Multiple Breast Cancer Polygenic Risk Score Panels in Women of Latin American Heritage

Publicado por
Huang, Xiaosong, Lott, Paul C., Hu, Donglei, Zavala, Valentina A., Jamal, Zoeb N., Vidaurre, Tatiana, Casavilca Zambrano, Sandro Angel Aníbal, Navarro Vásquez, Jeannie, Castañeda, Carlos A., Valencia, Guillermo, Morante, Zaida, Calderón, Mónica, Abugattas, Julio E., Fuentes, Hugo A., Liendo-Picoaga, Ruddy, Cotrina, Jose M., Neciosup, Silvia P., Rioja Viera, Patricia, Salinas, Luis A., Galvez-Nino, Marco, Huntsman, Scott, Sanchez, Sixto E., Williams, Michelle A., Gelaye, Bizu, Estrada-Florez, Ana P., Polanco-Echeverry, Guadalupe, Echeverry, Magdalena, Velez, Alejandro, Carmona-Valencia, Jenny A., Bohorquez-Lozano, Mabel E., Torres, Javier, Cruz, Miguel, Ho, Weang-Kee, Hwang Teo, Soo, Chee Tai, Mei, John, Esther M., Haiman, Christopher A., Conti, David V., Chen, Fei, Torres-Mejía, Gabriela, Kushi, Lawrence H., Neuhausen, Susan L., Ziv, Elad, Carvajal-Carmona, Luis G., Fejerman, Laura

Publicado 2025

Enlace

A substantial portion of the genetic predisposition for breast cancer is explained by multiple common genetic variants of relatively small effect. A subset of these variants, which have been identified mostly in individuals of European (EUR) and Asian ancestries, have been combined to construct a polygenic risk score (PRS) to predict breast cancer risk, but the prediction accuracy of existing PRSs in Hispanic/Latinx individuals (H/L) remain relatively low. We assessed the performance of several existing PRS panels with and without addition of H/L-specific variants among self-reported H/L women. PRS performance was evaluated using multivariable logistic regression and the area under the ROC curve. Both EUR and Asian PRSs performed worse in H/L samples compared with original reports. The best EUR PRS performed better than the best Asian PRS in pooled H/L samples. EUR PRSs had decreased per...