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artículo
Publicado 2021
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Monoclonal antibodies represent a fundamental cornerstone in the management of cancer. These advanced biological compounds have achieved a significant improvement of survival in patients. Among the most renown antibodies: rituximab, bevacizumab, cetuximab, trastuzumab are the most used in our local daily practice. In the last decade, immunotherapy has been positioned as an efficacious therapy for adverse diseases such as melanoma, lung, and renal neoplasms. In the nearest future, new conjugated antibodies, and CAR-T therapy will represent models of innovative strategies to cure cancer.
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Introduction: Waldenström's macroglobulinemia is a hematological neoplasm belonging to the group of monoclonal gammopathies, which includes systemic symptoms and those related to an increase in M paraprotein. Objective: To describe a case of cardiac amyloidosis associated with macroglobulinemia. Clinical case: Male patient who was admitted for asthenia, dysphonia, and who, during his evolution, developed progressive dyspnea, heart failure and pleural effusion. Additionally, echocardiography showed myocardial granular pattern, while pleural biopsy was positive for Congo red staining. Subsequently, he received treatment with bortezomib, dexamethasone and rituximab, with favorable evolution. Conclusions: In this disease, early diagnosis is an important advantage for survival. Therefore, its management is palliative of cardiac manifestations. The present case shows a diagnostic challenge, i...
3
artículo
Publicado 2022
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Introduction: Anemia is a global public health issue that affects mainly children aged less than 5 years. In Peru, despite the reduction in the prevalence of anemia between 2010 and 2018, anemia remains a major concern, especially in high-risk zones such as rural areas. Several sociodemographic factors have been associated with anemia in children; however, components contributing to the urban–rural gap have not been previously assessed. The purpose of this study was to evaluate the determinants of the difference in anemia prevalence between urban and rural areas, and its spatial distribution in Peruvian children aged 6–59 months. Methods: A secondary data analysis was conducted using the 2019 Peruvian Demographic Health Survey. The study population included 18 846 children aged 6–59 months. A multivariate decomposition analysis for non-linear response model was performed to identif...
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artículo
Publicado 2020
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Objective. The main of this research was to evaluate the clinicopathological characteristics of diffuse large B-cell lymphoma, no other specification (DLBCL, NOS) in a cohort of Peruvian patients diagnosed between 2005 and 2009. Methods. Seventy-two cases diagnosed with DLBCL, NOS, were studied at the National Institute of Neoplastic Diseases. Clinicopathological characteristics were evaluated and overall survival (OS) and other clinical parameters were compared according to cell of origin, Epstein-Barr virus (EBV) infection, and immunohistochemical (IHC) expression of MYC and BCL2. Results. There were 54 % women and 46 % men, with an average age of 65 years. 76 % were nodal, the majority cervical, and 24 % extranodal, with the stomach being the most affected site. The most frequent stages were II (35 %) and III (29 %), the majority with medium-high and high IPI. Histologically, almost a...
5
artículo
Publicado 2020
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Objective. To evaluate the clinicopathological characteristics of diffuse large B-cell lymphoma, not otherwise specified (LCBGD, NOS), in a cohort of peruvian patients. Methods. Seventy-two cases with a diagnosis of LCBGD, NOS, were studied at the INEN. Clinicopathological characteristics, overall survival (OS) and other clinical parameters were evaluated according to origin cell, Epstein-Barr virus infection (EBER), and the immunohistochemical expression (IHC) of MYC and BCL2. Results. There were 54% women and 46% men, with an average age of 65 years. 76% were ganglionic, the majority cervical location and 24% extranodal, the stomach being the most affected. The most frequent stages were II (35%) and III (29%), the majority with medium-high and high IPI. Histologically, almost all cases had centroblastic and immunoblastic morphology. There was a similar proportion of cases with germinal...
6
artículo
Publicado 2024
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Objetivo: estimar el rol de la edad como predictor de severidad por COVID-19 en pacientes pediátricos hospitalizados con diagnóstico de COVID-19 en un hospital de referencia peruano. Materiales y métodos: se llevó a cabo una cohorte retrospectiva que incluyó a pacientes pediátricos entre el mes de vida hasta una edad menor a 14 años, hospitalizados desde mayo del 2020 al 31 de diciembre del 2021 en el Hospital Nacional Edgardo Rebagliati Martins. La variable de exposición fue la edad escalada cada seis meses. La variable de desenlace fue la severidad de la COVID-19, determinada mediante los criterios de gravedad establecidos en la Guía de Práctica Clínica para el manejo de COVID-19 en pediatría de EsSalud. Se estimaron riesgos relativos (RR) crudos y ajustados, con sus respectivos intervalos de confianza al 95% (IC95%). Resultados: se analizó a un total de 331 pacie...
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artículo
Publicado 2024
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Background: Breast cancer is an important cause of cancer-related death in women worldwide and represents the second most frequent cause of brain metastases after lung cancer. The aim of this study was to determine the characteristics and outcomes of triple-negative breast cancer (TNBC) patients with brain metastasis (BM). Methods: We retrospectively reviewed a cohort of patients diagnosed with TNBC at the "Instituto Nacional de Enfermedades Neoplasicas" (period 2000-2014) to evaluate patients who developed BM. Survival rates were assessed by the Kaplan-Meier method, and prognostic factors were identified with the Cox regression analysis. Results: Of a total of 2007 TNBC patients, 193 (9.62%) developed BM. Of these, 169 stages I-III patients with a median age of 45 years (range:21-78) were included. The stage in this cohort was 4 (2.4%) clinical stage (CS) I, 23 (13.6%) with CS II and 14...
8
artículo
Publicado 2022
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Background: Breast cancer incidence in the United States is lower in Hispanic/Latina (H/L) compared with African American/ Black or Non-Hispanic White women. An Indigenous American breast cancer-protective germline variant (rs140068132) has been reported near the estrogen receptor 1 gene. This study tests the association of rs140068132 and other polymorphisms in the 6q25 region with subtype-specific breast cancer risk in H/Ls of high Indigenous American ancestry. Methods: Genotypes were obtained for 5,094 Peruvian women with (1,755) and without (3,337) breast cancer. Associations between genotype and overall and subtype-specific risk for the protective variant were tested using logistic regression models and conditional analyses, including other risk-associated polymorphisms in the region. Results: We replicated the reported association between rs140068132 and breast cancer risk overall ...
