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Association between Ancestry-Specific 6q25 Variants and Breast Cancer Subtypes in Peruvian Women

Publicado por
Zavala, Valentina A., Casavilca-Zambrano, Sandro, Navarro-Vásquez, Jeannie, Castañeda, Carlos A., Valencia, Guillermo, Morante, Zaida, Calderón, Monica, Abugattas, Julio E., Gómez, Henry, Fuentes, Hugo A., Liendo-Picoaga, Ruddy, Cotrina, Jose M., Monge, Claudia, Neciosup, Silvia P., Huntsman, Scott, Hu, Donglei, Sánchez, Sixto E., Williams, Michelle A., Núñez-Marrero, Angel, Godoy, Lenin, Hechmer, Aaron, Olshen, Adam B., Dutil, Julie, Ziv, Elad, Zabaleta, Jovanny, Gelaye, Bizu, Vásquez, Jule, Gálvez-Nino, Marco, Enriquez-Vera, Daniel, Vidaurre, Tatiana, Fejerman, Laura

Publicado 2022

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Background: Breast cancer incidence in the United States is lower in Hispanic/Latina (H/L) compared with African American/ Black or Non-Hispanic White women. An Indigenous American breast cancer-protective germline variant (rs140068132) has been reported near the estrogen receptor 1 gene. This study tests the association of rs140068132 and other polymorphisms in the 6q25 region with subtype-specific breast cancer risk in H/Ls of high Indigenous American ancestry. Methods: Genotypes were obtained for 5,094 Peruvian women with (1,755) and without (3,337) breast cancer. Associations between genotype and overall and subtype-specific risk for the protective variant were tested using logistic regression models and conditional analyses, including other risk-associated polymorphisms in the region. Results: We replicated the reported association between rs140068132 and breast cancer risk overall ...