Resultados de Búsqueda por Autor

Supplemental Table S4 from Evaluation of Multiple Breast Cancer Polygenic Risk Score Panels in Women of Latin American Heritage

Publicado por
Huang, Xiaosong, Lott, Paul C., Hu, Donglei, Zavala, Valentina A., Jamal, Zoeb N., Vidaurre, Tatiana, Casavilca Zambrano, Sandro Angel Aníbal, Navarro Vásquez, Jeannie, Castañeda, Carlos A., Valencia, Guillermo, Morante, Zaida, Calderón, Mónica, Abugattas, Julio E., Fuentes, Hugo A., Liendo-Picoaga, Ruddy, Cotrina, Jose M., Neciosup, Silvia P., Rioja Viera, Patricia, Salinas, Luis A., Galvez-Nino, Marco, Huntsman, Scott, Sanchez, Sixto E., Williams, Michelle A., Gelaye, Bizu, Estrada-Florez, Ana P., Polanco-Echeverry, Guadalupe, Echeverry, Magdalena, Velez, Alejandro, Carmona-Valencia, Jenny A., Bohorquez-Lozano, Mabel E., Torres, Javier, Cruz, Miguel, Ho, Weang-Kee, Hwang Teo, Soo, Chee Tai, Mei, John, Esther M., Haiman, Christopher A., Conti, David V., Chen, Fei, Torres-Mejía, Gabriela, Kushi, Lawrence H., Neuhausen, Susan L., Ziv, Elad, Carvajal-Carmona, Luis G., Fejerman, Laura

Publicado 2025

Enlace

A substantial portion of the genetic predisposition for breast cancer is explained by multiple common genetic variants of relatively small effect. A subset of these variants, which have been identified mostly in individuals of European (EUR) and Asian ancestries, have been combined to construct a polygenic risk score (PRS) to predict breast cancer risk, but the prediction accuracy of existing PRSs in Hispanic/Latinx individuals (H/L) remain relatively low. We assessed the performance of several existing PRS panels with and without addition of H/L-specific variants among self-reported H/L women. PRS performance was evaluated using multivariable logistic regression and the area under the ROC curve. Both EUR and Asian PRSs performed worse in H/L samples compared with original reports. The best EUR PRS performed better than the best Asian PRS in pooled H/L samples. EUR PRSs had decreased per...