Objective. To determine the association between the full moon and the incidence of vaginal preterm deliveries among women with vaginal delivery in a tertiary care hospital in Lima, Peru. Methods. An analytical cross-sectional study was carried out on a secondary data of the Certificate of Live Birth (CNV) of Peru. All newborns from the National Maternal Perinatal Institute were studied between the years 2013 and 2021. The duration of the full moon phase was determined through the programming language with Python 3.6 and the analysis of the incidence of prematurity with the STATA v15 statistical package. Results. 90,653 newborns were selected from the CNV national data, of which 11,563 (12.75%) participants were born during the days of the full moon and 79,089 (87.25%) during the other phases. A higher incidence of vaginal preterm births was observed during the full moon phase, compared t...

Objective. To determine the association between the full moon and the incidence of vaginal preterm deliveries among women with vaginal delivery in a tertiary care hospital in Lima, Peru. Methods. An analytical cross-sectional study was carried out on a secondary data of the Certificate of Live Birth (CNV) of Peru. All newborns from the National Maternal Perinatal Institute were studied between the years 2013 and 2021. The duration of the full moon phase was determined through the programming language with Python 3.6 and the analysis of the incidence of prematurity with the STATA v15 statistical package. Results. 90,653 newborns were selected from the CNV national data, of which 11,563 (12.75%) participants were born during the days of the full moon and 79,089 (87.25%) during the other phases. A higher incidence of vaginal preterm births was observed during the full moon phase, compared t...

Introducción: Las mucopolisacaridosis (MPS) son un grupo de alteraciones metabólicas hereditarias que ocurren por déficit de alguna de las enzimas que degradan los glicosaminoglicanos (GAG). La mucopolisacaridosis tipo II (MPS II), o síndrome de Hunter, es la única MPS con un patrón recesivo ligado al cromosoma X, afectando primariamente a los varones. Se caracteriza por una deficiencia de iduronato-2-sulfatasa (I2S), que contribuye a los signos y síntomas de esta enfermedad, y genera afectación multiorgánica y muerte temprana por acumulación tisular progresiva de los glicosaminoglicanos. Caso Clínico: Paciente varón de 7 años de edad con cuadro de distres respiratorio, que ingresa a Emergencia presentando crisis asmática. Como antecedente tiene diagnóstico hace 6 años de mucopolisacaridosis tipo II. Presenta las siguientes manifestaciones de la enfermedad: dismorfismo fa...

Introducción: Las mucopolisacaridosis (MPS) son un grupo de alteraciones metabólicas hereditarias que ocurren por déficit de alguna de las enzimas que degradan los glicosaminoglicanos (GAG). La mucopolisacaridosis tipo II (MPS II), o síndrome de Hunter, es la única MPS con un patrón recesivo ligado al cromosoma X, afectando primariamente a los varones. Se caracteriza por una deficiencia de iduronato-2-sulfatasa (I2S), que contribuye a los signos y síntomas de esta enfermedad, y genera afectación multiorgánica y muerte temprana por acumulación tisular progresiva de los glicosaminoglicanos. Caso Clínico: Paciente varón de 7 años de edad con cuadro de distres respiratorio, que ingresa a Emergencia presentando crisis asmática. Como antecedente tiene diagnóstico hace 6 años de mucopolisacaridosis tipo II. Presenta las siguientes manifestaciones de la enfermedad: dismorfismo fa...

Objetivo. Determinar si la trombocitopenia es un indicador predictivo de cierre deficitario de ductus arterioso en prematuros del INMP. Materiales y métodos. Se realizó un estudio de tipo casos y controles. Incluimos 250 recién nacidos prematuros nacidos entre enero a julio del 2016. 87 de ellos presentaron DAP. Empleamos un análisis estadístico descriptivo e inferencial utilizando el paquete estadístico SPSS v.23. Resultados. La trombocitopenia, encontrada en el primer día de vida estuvo asociada de forma estadísticamente significativa con la presencia de DAP (OR=8.9; IC: 95%, 4.7-16.8; p< 0,05). La curva ROC que nos reveló que la trombocitopenia es una prueba de baja sensibilidad (59.2%) y de alta especificidad (89.6%) para diagnosticar DAP. No encontramos asociación entre la respuesta al tratamiento con AINES y la trombocitopenia en estos sujetos. Conclusiones. La tromboc...

Objetivo: Estimar el riesgo del antecedente migratorio forzoso sobre los resultados maternos perinatales adversos en el Instituto Nacional Materno Perinatal (INMP) de Lima Perú durante 2022. Metodología: Se diseñó una cohorte retrospectiva que incluyó 400 gestantes expuestas al antecedente migratorio forzoso y 400 gestantes no expuestas atendidas por consultorios externos del INMP. Se aplicó un modelo de regresión de Poisson en el análisis inferencial bivariado y multivariado para cada desenlace de interés. Se considero un valor p < a 0.05 y un intervalo de confianza del 95 % para determinar significancia estadística. Resultados: Las gestantes expuestas al antecedente migratorio forzoso tuvieron predominantemente educación básica (primaria y secundaria) (85.75 % vs 72.5 %, p= 0.001), fueron amas de casa (85 % vs 75.5 %, p=0.004) y tuvieron controles prenatales inadecuados (3....

INTRODUCCIÓN: A pesar de que ductus arterioso persistente (DAP) es una de las cardiopatías congénitas más frecuentes a nivel mundial, sus implicancias patobiológicas continúan siendo un desafío científico mantenido por décadas. Una de las ultimas y más importantes contribuciones han sido los de Echtler y cols,1 quienes proponen una actividad protrombótica fundamental en el cierre funcional del ductus arterioso. OBJETIVO: Determinar si la trombocitopenia es un indicador predictivo de cierre deficitario de ductus arterioso en prematuros del Instituto Nacional Materno Perinatal (INMP) entre enero a julio del 2016. MATERIALES Y METODOS: Se realizó un estudio de tipo retrospectivo, casos y controles. La población estuvo constituida por 250 recién nacidos entre las 22 y 36 semanas de edad gestacional en el periodo de enero a julio del 2016. 87 recién nacidos presentaron DAP y 16...

Objetivo. Determinar si la trombocitopenia es un indicador predictivo de cierre deficitario de ductus arterioso en prematuros del INMP. Materiales y métodos. Se realizó un estudio de tipo casos y controles. Incluimos 250 recién nacidos prematuros nacidos entre enero a julio del 2016. 87 de ellos presentaron DAP. Empleamos un análisis estadístico descriptivo e inferencial utilizando el paquete estadístico SPSS v.23. Resultados. La trombocitopenia, encontrada en el primer día de vida estuvo asociada de forma estadísticamente significativa con la presencia de DAP (OR=8.9; IC: 95%, 4.7-16.8; p< 0,05). La curva ROC que nos reveló que la trombocitopenia es una prueba de baja sensibilidad (59.2%) y de alta especificidad (89.6%) para diagnosticar DAP. No encontramos asociación entre la respuesta al tratamiento con AINES y la trombocitopenia en estos sujetos. Conclusiones. La tromboc...

Sturge Weber syndrome (SSW) is characterized by the classic involvement of sporadic neuro-oculo-cutaneous vascular malformations, the pathophysiology of which to date has not been fully elucidated.The discovery of both an arterial and venous molecular profile in the endothelium present in vascular malformations, together with vascular atresia zones distal to the ectatic zones, have led to questioning the embryological theories put forward for decades, to explore the molecular and genetic characteristics in the affected tissue. Currently, a high prevalence of somatic mutation in the GNAQ gene has been reported in the affected tissues of patients with SSW, which encodes an alpha subunit of a Gq protein, whose signaling cascade stimulates cell proliferation, which may be responsible of the sustained growth of malformations in the three mentioned regions. The present study aims to explain th...

Sturge Weber syndrome (SSW) is characterized by the classic involvement of sporadic neuro-oculo-cutaneous vascular malformations, the pathophysiology of which to date has not been fully elucidated.The discovery of both an arterial and venous molecular profile in the endothelium present in vascular malformations, together with vascular atresia zones distal to the ectatic zones, have led to questioning the embryological theories put forward for decades, to explore the molecular and genetic characteristics in the affected tissue. Currently, a high prevalence of somatic mutation in the GNAQ gene has been reported in the affected tissues of patients with SSW, which encodes an alpha subunit of a Gq protein, whose signaling cascade stimulates cell proliferation, which may be responsible of the sustained growth of malformations in the three mentioned regions. The present study aims to explain th...

Congenital pulmonary airway malformation (MCVAP), formerly known as congenital cystic adenomatoid pulmonary malformation (MAQP), belongs to the group of congenital pulmonary malformations, representing 95% of these. It is characterized by varying degrees of respiratory distress according to the level of the airway that compromises the injury and may be incompatible with life until it goes unnoticed until early adulthood. Advances in molecular biology have discovered that there is an imbalance between proliferating and apoptotic genes within these lesions, disrupting the segmentation of the bronchial tree, triggering the formation of these lesions. On the other hand, advances in fetal ultrasound have allowed 50% of cases to be detected from fetal life, causing these children to have their lesions removed during the first weeks of life and their improved life prognosis. This literary ...

La malformación congénita de la vía aérea pulmonar (MCVAP), antiguamente conocida como malformación adenomatoide quística congénita del pulmon (MAQP), pertenece al grupo de las malformaciones congénitas pulmonares, representando al 95% de estas. Se caracteriza por distintos grados de distress respiratorio según el nivel de la vía aérea que comprometa la lesión pudiendo ser desde incompatible con la vida hasta pasar inadvertida hasta adultez temprana. Los adelantos de la biología molecular han descubierto que existe un disbalance entre los genes proliferadores y apoptoticos dentro de estas lesiones interrumpiendo la segmentación del árbol bronquial desencadenando la formación de estas lesiones. Por su lado los avances en la ecografía fetal han permitido que se detecten el 50% de los casos desde la vida fetal, logrando que a estos niños se les extirpe la lesión durante l...

Objective: To determine the factors associated with the level of knowledge about exclusive breastfeeding in first-time mothers attended by teleconsultation of the National Maternal-Perinatal Institute in 2020. Materials and methods: Study with a quantitative approach, descriptive, observational, cross-sectional, and analytical design. The population was made up of a total of 1000 primiparous mothers attended by teleconsultation at the National Maternal Perinatal Institute, taking a representative sample of 240. A reliable and valid instrument was used to measure knowledge in exclusive breastfeeding, statistical association tests were performed and bivariate and multiple Poisson regression model to obtain the raw and adjusted prevalence ratio and their 95% confidence intervals for the associated factors and exclusive breastfeeding categories. Results: a high 75.7% level of knowledge about...

Objective: To determine the factors associated with the level of knowledge about exclusive breastfeeding in first-time mothers attended by teleconsultation of the National Maternal-Perinatal Institute in 2020. Materials and methods: Study with a quantitative approach, descriptive, observational, cross-sectional, and analytical design. The population was made up of a total of 1000 primiparous mothers attended by teleconsultation at the National Maternal Perinatal Institute, taking a representative sample of 240. A reliable and valid instrument was used to measure knowledge in exclusive breastfeeding, statistical association tests were performed and bivariate and multiple Poisson regression model to obtain the raw and adjusted prevalence ratio and their 95% confidence intervals for the associated factors and exclusive breastfeeding categories. Results: a high 75.7% level of knowledge about...

ABSTRACT Introduction: The evolution of the COVID-19 pandemic varies in each population; it has been complicating health systems worldwide. Objective: to analyze the evolution of the Covid-19 pandemic, estimating the effect of the containment measures practiced in Peru. Material and Method: The SIR epidemiological mathematical modeling was applied, estimating the COVID-19 evolution in our population. Data analysis was performed following the SIR mathematical model with defined ordinary differential equations to simulate epidemiological behavior; and it was executed in the RStudio programming language. Results: Containment measures decreased the propagation rate, reducing 30% of infected cases until the peak day of infection; however, it is still above the effective reproductive number to control the epidemic and it shows an erratic trend, the result of government actions being 61% in the...

Introduction: The evolution of the COVID-19 pandemic varies in each population; it has been complicating health systems worldwide. Objective: to analyze the evolution of the Covid-19 pandemic, estimating the effect of the containment measures practiced in Peru. Material and Method: The SIR epidemiological mathematical modeling was applied, estimating the COVID-19 evolution in our population. Data analysis was performed following the SIR mathematical model with defined ordinary differential equations to simulate epidemiological behavior; and it was executed in the RStudio programming language. Results: Containment measures decreased the propagation rate, reducing 30% of infected cases until the peak day of infection; however, it is still above the effective reproductive number to control the epidemic and it shows an erratic trend, the result of government actions being 61% in the practice...

Objective. Estimate the prevalence and determine the factors associated with access to modern family planning methods (MPFM) in women of childbearing age Venezuelan immigrants in Peru. Materials and methods. Observational, cross-sectional and analytical study of the Survey Directed to the Venezuelan Population Residing in the Country (ENPOVE) 2018. The proportion of women of fertile age Venezuelan immigrants with access to MPFM was calculated. Crude and adjusted prevalence ratios (RP) of MPFM access were estimated, using generalized linear models. Results. 3,378 Venezuelan immigrant women of childbearing age were included. 78.45% did not have access to MMPF. Being in the young stage of life (RPa: 1.07; IC: 1.05-1.14), being married (RPa: 1.09; IC: 1.03-1.14), living together (RPc: 1.11; IC: 1.06-1.16), residing in the city de Trujillo (RPa: 1.21; CI: 1.13-1.29) were associated with a hig...

Objective. Estimate the prevalence and determine the factors associated with access to modern family planning methods (MPFM) in women of childbearing age Venezuelan immigrants in Peru. Materials and methods. Observational, cross-sectional and analytical study of the Survey Directed to the Venezuelan Population Residing in the Country (ENPOVE) 2018. The proportion of women of fertile age Venezuelan immigrants with access to MPFM was calculated. Crude and adjusted prevalence ratios (RP) of MPFM access were estimated, using generalized linear models. Results. 3,378 Venezuelan immigrant women of childbearing age were included. 78.45% did not have access to MMPF. Being in the young stage of life (RPa: 1.07; IC: 1.05-1.14), being married (RPa: 1.09; IC: 1.03-1.14), living together (RPc: 1.11; IC: 1.06-1.16), residing in the city de Trujillo (RPa: 1.21; CI: 1.13-1.29) were associated with a hig...

Objetivo: Comparar los resultados del embarazo entre mujeres con y sin COVID-19 atendidas en un hospital nacional de nivel III de Perú. Método: Estudio observacional, retrospectivo y comparativo. Participaron gestantes con RT-PCR positiva y negativa en razón 1:1, y 1:2 con gestantes del año 2019. Se recogió información materna y perinatal. Se usó la prueba exacta de Fisher con significancia de 0,05 y razones de prevalencia (RP) con intervalo de confianza del 95% (IC95%). Resultados: Participaron 51 gestantes con RT-PCR positiva, 51 gestantes con RT-PCR negativa y 102 gestantes del año 2019. Se observó asociación entre los resultados de la RT-PCR y el parto pretérmino (p < 0,05). La RP de parto pretérmino en las gestantes con RT-PCR positiva fue de 3,14 (IC95%: 1,29-7,64) veces en comparación con las gestantes de 2019 y de 4,0 (IC95%: 1,13-14,17) veces en comparación con las...

Introduction: Adherence to clinical practice guidelines (CPG) improves the management of neonatal sepsis, reducing complications and mortality in newborns. Objective: To identify factors associated with adherence to CPG for neonatal sepsis at the Instituto Nacional Materno Perinatal (INMP). Material and Methods: A retrospective case-control study was conducted at the INMP, analyzing 988 neonatal sepsis hospitalizations between May and December 2021. Maternal and neonatal variables were evaluated using a mixed-effects logistic regression model to estimate adjusted prevalence ratios with 95% confidence intervals (CI95%). Results: Overall adherence to CPG was 75%, higher in early-onset sepsis (81,4%) than in late-onset sepsis (66,9%). Late-onset sepsis was associated with lower adherence (adjusted OR=1.37; CI95 %=1.05-1.78; p<0.01). Care provided by non-neonatologist pediatricians reduce...