Currently, cancers of infectious origin, represent a public health problem, especially in emergent countries. After its discovery more than 50 years ago, arduous efforts have been made to identify the agents involved, their routes of transmission and their carcinogenesis mechanisms, in order to develop effective prevention measures.

Actualmente los canceres de origen infeccioso representan un problema de salud pública, especialmente en países subdesarrollados. Esta carta al editor está enfocada en la prevención de estas neoplasias a diversos niveles.

Estimado señor editor:  Luego de haber leído con interés el artículo “Resultados perinatales de embarazos con corioamnionitis en un Hospital de nivel III de Lima, 2016 a 2018” por la Dra Carmen Carolina De La Cruz-Dávila et al publicado en el número Numero 1, Volumen 9 de su revista; el cual consideramos un estudio de amplia relevancia en el campo de la Gineco-Obstetricia y Neonatología; por su extenso impacto en la salud materna y en la morbimortalidad neonatal en el Perú; quisiéramos acotar la importancia de reportar también la retinopatía de la prematuridad (RP) como posible complicación de corioamnionitis en futuros estudios y del análisis anatomopatológico de la placenta como fuerte indicador pronóstico de los recién nacidos con esta patología en futuros estudios de la institución.  La RP es un trastorno vasoproliferativo de la retina que ocurre como ...

Estimado señor editor: Luego de haber leído con interés el artículo “Utilidad del score SOFA en la predicción de muerte materna en la UCI materna del INMP” por De la Peña Meniz Walter et al. publicado en el Volumen 9 número 3 de la Revista Peruana de Investigación Materno Perinatal, el cual consideramos un estudio de suma relevancia en el campo de la Gineco-Obstetricia y la Medicina Intensivista; y teniendo en cuenta la alta tasa de mortalidad materna en el Perú; quisiéramos mencionar algunos aspectos que deberían considerarse para posteriores estudios. Actualmente no existe un score específico para predecir la mortalidad materna en pacientes obstétricas en la UCI. Sin embargo, a pesar de que no hay muchos estudios al respecto, el score SOFA es el que ha presentado los mejores resultados en contraste con otros scores para valorar mortalidad. Esto puede verse ilustrado en...

Abstract Introduction: SARS-CoV-2 infection can produce a hypercoagulable state and increase the risk of developing thrombotic events. Several observational studies have reported an association between D-dimer levels on admission and mortality from COVID-19. Objective: The objective of the present study was to determine the prognostic capacity of D-dimer in predicting mortality from COVID-19 in patients hospitalized in the Intensive Care Unit. Methods: An observational, analytical and retrospective cohort design was used. A sample size of 324 hospitalized patients was calculated, who were followed during the period January to July 2021 to evaluate the outcome of disease. For statistical analysis, the SPSS version 26 statistical package was used. Results: A cut-off point of 1.40 µg/mL was calculated for D-dimer values ​​with a sensitivity of 80.9%, a specificity of 86.4% and area und...

Introduction: Acral lentiginous melanoma (ALM) is the fourth type of cutaneous melanoma and is the most common subtype in some countries in Latin America and Asia. The neutrophil-lymphocyte ratio (NLR) is an inflammatory marker that has been shown to be useful as a prognostic tool in several malignant neoplasms. Objective: The objective of the study was to evaluate whether NLR has prognostic value in ALM. A retrospective study was conducted that included patients with ALM between 2010 and 2015. Methods: An observational, analytical and retrospective cohort design was used. We worked with a total population of 69 patients with the diagnosis of acral lentiginous melanoma. For the statistical analysis, the SPSS statistical package version 26 was used. Univariate and multivariate Cox proportional regression models were performed. Results: A total of 69 patients with ALM were included. The me...

Introducción: El coriocarcinoma gástrico primario (CGP) es una neoplasia infrecuente y altamente agresiva que representa menos de 0.1% de todos los cánceres gástricos. Esta neoplasia suele ser frecuentemente confundida con adenocarcinoma gástrico debido a que comparte características clínicas, epidemiológicas e histopatológicas similares, por lo que es importante mantener una alta sospecha de esta entidad. Reporte de caso: Se presenta un el caso de una paciente mujer de 64 años que acudió al hospital con síntomas gastrointestinales inespecíficos que incluían anemia, fatiga y llenura precoz. La biopsia endoscópica de la lesión reveló la presencia de CGP en estadio clínico IV que presentó una respuesta parcial luego de 4 ciclos de quimioterapia con el esquema EMA/EP (Etoposido 140 mg, Metotrexate 440 mg, Actinomicina D 0.5 mg/ Etoposido 220 mg, cisplatino 110 mg). Conclu...

Objetivo: Determinar la utilidad del índice triglicérido glucosa (ITG) para el diagnóstico de síndrome metabólico en pacientes atendidos en un establecimiento de atención primaria de la selva peruana durante el periodo 2022-2023. Metodología: Se empleó un diseño de tipo cuantitativo, observacional, analítico, retrospectivo y de tipo prueba diagnóstica. Se calculó un tamaño muestral de 363 pacientes, quienes fueron divididos en dos grupos de acuerdo a la presencia o ausencia de síndrome metabólico. Resultados: Se obtuvo un punto de corte de 8.9674 para los valores de ITG con una sensibilidad de 89.5 % y una especificidad de 64.3 % para el diagnóstico de síndrome metabólico. El área bajo la curva (AUC) para ITG fue de 0.889 (IC 95 %: 0.851 – 0.922, p<0.005). Adicionalmente, se calcularon los valores predictivos positivo (82.49 %), negativo (76.42 %) y precisión diagn�...

Introduction: Primary gastric choriocarcinoma (PGC) is a rare and highly aggressive neoplasm that represents less than 0.1% of all gastric cancers. This neoplasm is often confused with gastric adenocarcinoma because it shares clinical, epidemiological and histopathological characteristics, so it is important to maintain a high suspicion of this entity. Case of report: A case of a 64-year-old woman who came to the hospital with non-specific gastrointestinal symptoms that arose anemia, fatigue and early fullness is presented. The endoscopic biopsy of the lesion revealed the presence of PGC in clinical stage IV that presented a partial response after 4 cycles of chemotherapy with the EMA/EP regimen (Etoposide 140 mg, Methotrexate 440 mg, Actinomycin D 0.5 mg/ Etoposide 220 mg, cisplatin 110 mg). Conclusion: To emphasize the poor prognosis of extragonadal choriocarcinomas in contrast to gona...

Introducción: La pandemia por SARS-CoV-2 representa un problema de salud pública en la actualidad. En los últimos años se ha estudiado diversos biomarcardores de fácil de obtención y bajo costo para poder determinar los casos severos que requieran un manejo más invasivo. Objetivo: Determinar la capacidad de la proteína C-reactiva para predecir severidad de infección por SARS-CoV-2 en pacientes hospitalizados en el Centro Médico Naval durante el periodo enero-setiembre en el año 2021. Metodología: Se empleó un diseño de tipo cuantitativo, observacional, analítico, retrospectivo, transversal y de tipo prueba diagnóstica. Se calculó un tamaño muestral de 503 pacientes que fueron divididos en dos grupos de acuerdo a su severidad. Resultados: Se encontró una asociación entre la proteína C-reactiva y la severidad de infección por SARS-CoV-2 en un modelo ajustado (OR ajust...

Estimado señor editor:  Luego de haber leído con interés el artículo “Resultados perinatales de embarazos con corioamnionitis en un Hospital de nivel III de Lima, 2016 a 2018” por la Dra Carmen Carolina De La Cruz-Dávila et al publicado en el número Numero 1, Volumen 9 de su revista; el cual consideramos un estudio de amplia relevancia en el campo de la Gineco-Obstetricia y Neonatología; por su extenso impacto en la salud materna y en la morbimortalidad neonatal en el Perú; quisiéramos acotar la importancia de reportar también la retinopatía de la prematuridad (RP) como posible complicación de corioamnionitis en futuros estudios y del análisis anatomopatológico de la placenta como fuerte indicador pronóstico de los recién nacidos con esta patología en futuros estudios de la institución.  La RP es un trastorno vasoproliferativo de la retina que ocurre como ...

Estimado señor editor: Luego de haber leído con interés el artículo “Utilidad del score SOFA en la predicción de muerte materna en la UCI materna del INMP” por De la Peña Meniz Walter et al. publicado en el Volumen 9 número 3 de la Revista Peruana de Investigación Materno Perinatal, el cual consideramos un estudio de suma relevancia en el campo de la Gineco-Obstetricia y la Medicina Intensivista; y teniendo en cuenta la alta tasa de mortalidad materna en el Perú; quisiéramos mencionar algunos aspectos que deberían considerarse para posteriores estudios. Actualmente no existe un score específico para predecir la mortalidad materna en pacientes obstétricas en la UCI. Sin embargo, a pesar de que no hay muchos estudios al respecto, el score SOFA es el que ha presentado los mejores resultados en contraste con otros scores para valorar mortalidad. Esto puede verse ilustrado en...

Objective: The aim of this study was to determine the association betweenwaist to height ratio and uncomplicated cystitis in a primary health care center in Lima, during the year 2018. Methods: We conducted an observational, analytical, case-control study, in which a total of 131 cases and 131 controls were obtained by simple random sample, applying exclusion and inclusion criteria. Retrospective recollection of the data was performed using the medical record of each selected patient. Odds ratio was calculated to measure the strength of association. Results: the waist to height ratio mean for uncomplicated cystitis was 61,9 ± 6.39 and 58.12 ± 3.87 for the controls. We found an statistical significant association between uncomplicated cystitis and waist to height ratio (OR 5,27; 95%CI 3,10 – 8,95; p &lt;0,001). Waist circumference (OR 2,11 95%CI;1,26 – 3,55; p=0,005) and body ma...

Objective: The aim of this study was to determine the association betweenwaist to height ratio and uncomplicated cystitis in a primary health care center in Lima, during the year 2018. Methods: We conducted an observational, analytical, case-control study, in which a total of 131 cases and 131 controls were obtained by simple random sample, applying exclusion and inclusion criteria. Retrospective recollection of the data was performed using the medical record of each selected patient. Odds ratio was calculated to measure the strength of association. Results: the waist to height ratio mean for uncomplicated cystitis was 61,9 ± 6.39 and 58.12 ± 3.87 for the controls. We found an statistical significant association between uncomplicated cystitis and waist to height ratio (OR 5,27; 95%CI 3,10 – 8,95; p &lt;0,001). Waist circumference (OR 2,11 95%CI;1,26 – 3,55; p=0,005) and body ma...

Objective: To determine the relationship between gastroesophageal reflux disease and bronchial asthma in the pediatric population of the National Children's Hospital Breña headquarters between the years 2017-2018. Methods: An analytical observational study of cases and controls was not matched, with a ratio of 1 case to 2 controls, with a total of 45 cases and 90 controls, a simple random probability sampling was performed, with a retrospective collection for the variables bronchial asthma, GERD, GERDinduced esophagitis, prematurity, interrupted breastfeeding, sex and age. A bivariate and multiple logistic regression model was performed to obtain the Odds Ratio for the strength of association. Results: A statistically significant difference was found for GERD (p = 0.002), being 33.33% and 11.11% for cases and controls, as well as for interrupted lactation (p = 0.013); by multiple logist...

Objective: To determine the relationship between gastroesophageal reflux disease and bronchial asthma in the pediatric population of the National Children's Hospital Breña headquarters between the years 2017-2018. Methods: An analytical observational study of cases and controls was not matched, with a ratio of 1 case to 2 controls, with a total of 45 cases and 90 controls, a simple random probability sampling was performed, with a retrospective collection for the variables bronchial asthma, GERD, GERDinduced esophagitis, prematurity, interrupted breastfeeding, sex and age. A bivariate and multiple logistic regression model was performed to obtain the Odds Ratio for the strength of association. Results: A statistically significant difference was found for GERD (p = 0.002), being 33.33% and 11.11% for cases and controls, as well as for interrupted lactation (p = 0.013); by multiple logist...

Objectives: to determine the relationship between exclusive breastfeeding during the first 6 months of life and bronchial asthma in the pediatric population at the National Police Hospital in 2016.  Materials and methods: an analytical observational study of cases and controls was not matched. ratio 1 case for 3 controls, with a total of 53 cases and 159 controls, a simple random probability sampling was performed, with a retrospective collection for the variables exclusive breastfeeding, Prematurity, sex and age. A bivariate and multiple logistic regression model was performed to obtain the Odds Ratio for the strength of association. Results: being 24.53% and 44.65% exclusive breastfeeding for cases and controls, a statistically significant difference was found (p = 0.009). By multiple logistic regression analysis exclusive breastfeeding (OR 0.41, p = 0.014, IC 0.20-0.84) show...

Objectives: to determine the relationship between exclusive breastfeeding during the first 6 months of life and bronchial asthma in the pediatric population at the National Police Hospital in 2016.  Materials and methods: an analytical observational study of cases and controls was not matched. ratio 1 case for 3 controls, with a total of 53 cases and 159 controls, a simple random probability sampling was performed, with a retrospective collection for the variables exclusive breastfeeding, Prematurity, sex and age. A bivariate and multiple logistic regression model was performed to obtain the Odds Ratio for the strength of association. Results: being 24.53% and 44.65% exclusive breastfeeding for cases and controls, a statistically significant difference was found (p = 0.009). By multiple logistic regression analysis exclusive breastfeeding (OR 0.41, p = 0.014, IC 0.20-0.84) show...

Sturge Weber syndrome (SSW) is characterized by the classic involvement of sporadic neuro-oculo-cutaneous vascular malformations, the pathophysiology of which to date has not been fully elucidated.The discovery of both an arterial and venous molecular profile in the endothelium present in vascular malformations, together with vascular atresia zones distal to the ectatic zones, have led to questioning the embryological theories put forward for decades, to explore the molecular and genetic characteristics in the affected tissue. Currently, a high prevalence of somatic mutation in the GNAQ gene has been reported in the affected tissues of patients with SSW, which encodes an alpha subunit of a Gq protein, whose signaling cascade stimulates cell proliferation, which may be responsible of the sustained growth of malformations in the three mentioned regions. The present study aims to explain th...

Sturge Weber syndrome (SSW) is characterized by the classic involvement of sporadic neuro-oculo-cutaneous vascular malformations, the pathophysiology of which to date has not been fully elucidated.The discovery of both an arterial and venous molecular profile in the endothelium present in vascular malformations, together with vascular atresia zones distal to the ectatic zones, have led to questioning the embryological theories put forward for decades, to explore the molecular and genetic characteristics in the affected tissue. Currently, a high prevalence of somatic mutation in the GNAQ gene has been reported in the affected tissues of patients with SSW, which encodes an alpha subunit of a Gq protein, whose signaling cascade stimulates cell proliferation, which may be responsible of the sustained growth of malformations in the three mentioned regions. The present study aims to explain th...