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1013961
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1013962
artículo
Publicado 2025
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Introducción: En 2022 el Perú aprobó una norma técnica del odontograma, que estandariza la información en la historia clínica para fines legales de los usuarios y responsabilidad del profesional. Objetivo: El propósito del estudio fue determinar el conocimiento de los odontólogos sobre la norma técnica del odontograma en odontólogos. Materiales y Métodos: Este estudio observacional transversal se realizó en una muestra de 187 odontólogos (116 docentes y 71 estudiantes de posgrado) de 22 a 62 años (65,5% mujeres, edad media 38,22 ± 12,19) de una universidad privada en Lima. Un cuestionario de 30 preguntas valorado de 0 a 30 puntos se distribuyó proporcionalmente en tres dimensiones: hallazgos clínicos (D1), disposiciones (D2) y terminología (D3). Datos demográficos de edad, sexo, tipo de participante/estudio y tiempo de experiencia profesional fueron incluidos. El cuest...
1013963
artículo
Publicado 2025
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Objective: To determine the level of general knowledge, warning signs and prevention of dengue in the population of a non-endemic region of Peru. Material and Methods: A quantitative, descriptive and observational cross-sectional study was conducted in Arequipa, Peru, to evaluate the level of general knowledge, warning signs and prevention of dengue fever in the population of a non-endemic region, including 1000 rural residents over 18 years of age. A validated questionnaire was used, composed of 11 questions in 34 items. Results: In a sample of inhabitants of a non-endemic region of Peru, about nine out of ten had a low level of knowledge about dengue. The lowest levels were reported for warning signs (84.1%), prevention (74.9%) and general aspects of dengue (66.0%). Only 33.5% recognized the dengue vector; as for knowledge about prevention, 17.6% answered correctly about vector reprodu...
1013964
artículo
Publicado 2025
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Introduction: REG1B is a protein involved in cell regeneration, whose regulation may vary depending on the health or disease status. Objective: to identify pancreatic biomarkers associated with REG1B in patients with chronic pancreatitis and healthy subjects. Materials and method: Secondary data cut-off study of 302 patients. The variables were: regenerating protein of the islets of Langerhans 1B and 1A (REG1B; REG1A), hyaluronan receptor 1 of the lymphatic endothelium (LYVE-1), Trefoil factor-1 (TFF1), carbohydrate antigen 19-9 (CA19-9). Spearman correlation, multiple linear regression and scatter plot were used. Results: In healthy subjects (n=183), REG1B showed significant and positive correlations with LYVE1 (rho=0.459,p<0.001), TFF1 (rho=0.549,p<0.001) and REG1A (rho=0.780,p<0.001). There was no significant correlation with CA19-9 (rho=0.153,p=0.144). In chronic pancreatiti...
1013965
artículo
Introducción: El carcinoma adrenocortical (CAC), el segundo tumor endocrino maligno más frecuente, se origina en la corteza suprarrenal y se diagnostica principalmente en personas de mediana edad. El CAC funcionante suele presentarse con hiperandrogenismo, con o sin hipercortisolismo. Aproximadamente el 50 % de los casos son funcionantes. Reporte de caso: Presentamos los casos de dos mujeres adultas que manifestaron hiperandrogenismo y una masa abdominal gigante al examen físico. El diagnóstico de CAC fue confirmado mediante análisis histopatológico. Discusión: El CAC funcionante se presenta típicamente con una gran masa abdominal y niveles elevados de hormonas suprarrenales. El diagnóstico incluye pruebas hormonales y estudios de imagen. La tomografía computarizada es fundamental en la evaluación inicial del CAC, ya que permite identificar características como la heterogen...
1013966
1013967
artículo
Publicado 2025
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Introduction: Zika is an emerging arboviral disease that entered Peru in 2016, associated with congenital malformations and neurological complications. Objective: To analyze the incidence and distribution of Zika and identify complications in pregnant women in Peru during the 2016–2023 period. Materials and methods: Observational, descriptive study based on secondary data from the national epidemiological surveillance system. Annual incidence rates (AIR) and average annual incidence rates (AAIR) were calculated by age group, sex, and geographic region. Results: A total of 4529 confirmed cases were reported (national AAIR: 2.62 per 100,000 population), with an epidemic peak in 2019 (AIR: 11.03 per 100,000). Focal outbreaks were identified in 12 departments, with the highest burden in Cajamarca (AAIR: 17.42) and Loreto (AAIR: 11.59). The highest AAIR was observed among young adults (2.04...
1013968
artículo
Publicado 2025
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Background: Invasive fungal infections (IFIs) significantly increase morbidity and mortality in patients with acute myeloid leukemia (AML) undergoing induction chemotherapy. Although posaconazole is recommended as first-line antifungal prophylaxis, real-world data from Latin American settings remain limited. Objective: To evaluate the real-world effectiveness of posaconazole as antifungal prophylaxis in AML patients receiving induction chemotherapy at a referral hospital in Lima, Peru. Materials and Methods: This retrospective observational study included 94 patients with AML who received induction chemotherapy between 2017 and 2020. The patients were divided into three groups based on the type of antifungal prophylaxis: posaconazole, fluconazole, or no prophylaxis. IFI rates were compared across groups. Results: Posaconazole prophylaxis was associated with a statistically significantly ...
1013969
artículo
Publicado 2025
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Up to 80% of patients with hypothyroidism present with neuromuscular symptoms. We report the case of a 56-year-old male with a two-year history of symptoms suggestive of hypothyroidism, which worsened over the last five months, with difficulty walking, muscle rigidity, and cramps. Laboratory tests confirmed primary hypothyroidism with elevated creatine kinase (CK) and lactate dehydrogenase (LDH) levels. Following treatment with levothyroxine, the clinical and biochemical response was favorable. Hoffmann syndrome, an atypical form of hypothyroid myopathy, is rare and primarily affects males with long-standing hypothyroidism. It is characterized by pseudohypertrophy and progressive muscle weakness, affecting less than 10% of hypothyroid patients. The pathogenesis is thought to involve alterations in the IGF1–PI3K–Akt/mTOR and myostatin-Smad3 pathways. Treatment with levothyroxine norma...
1013970
artículo
Postoperative pancreatic fistula (POPF) is the most common complication after cephalic pancreatoduodenectomy (CPD) and occurs in 3 to 45% of cases. It is associated with morbid sequelae including intra-abdominal sepsis, hemorrhage, among other. Which carries a high mortality up to 40%. Surgery is the best option in severe cases. Different surgical procedures have been tried for its treatment with different results. We present the case of a 60-year-old male patient who presented POPF after CPD and a wirsungostomy was performed as a bridge surgery until a pancreatogastro anastomosis was performed as definitive treatment.
1013971
artículo
Publicado 2025
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We present the case of a 5-year-old male patient with a medical history of recurrent bronchospasms since 3 months . He went to the pediatric allergy clinic at the Edgardo Rebagliati Martins National Hospital with his mother, who reported episodes of acute urticaria, one after consuming cooked pork and another 2 after consuming cooked beef. To the evaluation, non-contributory exam. The following tests were performed: specific IgE in vitro, where a positive result was obtained for pork albumin (26.6 KUA/L) and later skin tests, with a positive result for raw pork. Due to the appearance of lesions only after the consumption of cooked mammalian meat, alpha-gal syndrome was suspected and specific IgE testing against alpha-gal was requested through an external laboratory, which came back positive (>100 kU/L).
1013972
artículo
Publicado 2025
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Objective: To determine the association between the number of prenatal controls (PCN) and the prevalence of low birth weight (LBW) in individuals born during the post-COVID-19 era in Peru. Materials and Methods: This is a secondary study based on data from the 2022 National Demographic and Family Health Survey (ENDES). Low birth weight (LBW) was defined as a birth weight less than 2500 g. Sociodemographic and clinical variables were also evaluated to control for their influence and possible confounding effects on the study relationship. Results A prevalence of LBW of 4.1% was found. The adjusted analysis showed that for each completed CPN in pregnant women, the prevalence of LBW decreased by 12% (aPR: 0.88; 95% CI: 0.80-0.96). A significant association was also found between LBW and factors such as iron supplementation (aPR: 7.42; 95% CI: 1.05-52.32) and having Spanish as the mother tong...
1013973
artículo
Publicado 2025
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Background: Colorectal polyps are tumors that protrude into the lumen of the gastrointestinal tract and, in the pediatric population, are most commonly located in the rectosigmoid region, being predominantly benign. Objective: To describe the epidemiological, clinical, endoscopic, and histological characteristics of children with colorectal polyps treated in Chiclayo, Peru. Materials and Methods: Observational, descriptive, retrospective, and cross-sectional study conducted between July 2013 and February 2022, including patients with an endoscopic diagnosis of colorectal polyps. Results: A total of 109 patients were included (median age: 6 years; slight female predominance). All patients presented with rectal bleeding, and 40% exhibited polyp prolapse through the anus. A single polyp was identified in 70.6% of cases, while 3.7% had polyposis. A total of 178 polyps were removed, 75.8% of ...
1013974
artículo
Publicado 2025
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Introduction: The infiltration of botulinum toxin type A causes chemical denervation of the abdominal wall muscles surrounding the hernia defects of complex eventrations, favoring their repair. Report: 11 cases aren presented with complex eventrations, whose lateral muscle complexes were infiltrated, with botulinum toxin type A (Botox®), as a prehabilitative measure. In the post-infiltration tomographic images, we observed a decrease in the transverse diameter of the right lateral complex between 0.2 to 2 cm and between 0.6 to 1.5 cm on the left side, which represented a reduction of 38% and 40% respectively. In more than 90% of cases, complete fascial closure of the defect was achieved. Conclusion: The use of botulinum toxin type A, in complex incisional hernias, due to its relaxing action on the infiltrated muscles, causes thinning, therefore muscle elongation, favoring aponeurotic cl...
1013975
1013976
artículo
Publicado 2025
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Introduction: Arterial hypertension seems to have an impact on mental health, and there are no longitudinal studies in our context that have evaluated this association. Objective: To evaluate the association between hypertension and changes in the levels of perceived stress in adults aged 30-69 years in the Tumbes region. Materials and Methods: Secondary analysis of data from a longitudinal population-based study. The dependent variable was the level of perceived stress assessed by Cohen's 14-item scale (low, medium and high according to tertiles), whereas the presence of arterial hypertension, the independent variable, was defined according to JNC-7 criteria. The association of interest was assessed both at the beginning of the cohort and during follow-up using crude and adjusted Poisson regression models in both cases. Results: Of the 1609 participants, mean age 48.2 (SD: 10.6), 810 (5...
1013977
artículo
No aplica.
1013978
1013979
artículo
Publicado 2025
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Introduction: The present study arises in response to the sustained increase in dengue outbreaks in Latin America, with special emphasis on the state of Zulia, Venezuela. This region, composed of 21 municipalities, is highly vulnerable to dengue transmission. Given this scenario, it is essential to have tools that allow early detection of outbreaks and, thus, optimize prevention and public health intervention strategies. The main objective is to develop an early warning system for dengue outbreaks using machine learning (ML) techniques. Materials and methods: Several data sources are integrated: epidemiological information, meteorological parameters, El Niño and La Niña (Niño 3.4 Index), socioeconomic and demographic variables. Two ML models were used: Support Vector Machine for regression (SVM-R) and Gaussian Process Regression (GPR). Results: The predictions obtained showed remarkab...
1013980
