Ludwig’s angina is a rapidly progressive cellulitis that involves sub mandibular, sub lingual and submental spaces bilaterrally. This was due mainly to per apical infections of the second and third mandible molars. Due to the rapid advancement of the clinical (which in certain occasions could even threaten the patient’s life) it is extremely important to know clearly the criteria for early diagnosis of Ludwig’s angina, which will enable us to provide the most appropriate treatment to halt the progress of the clinical and will prevent the onset of life-threatening complications.

Ludwig’s angina is a rapidly progressive cellulitis that involves sub mandibular, sub lingual and submental spaces bilaterrally. This was due mainly to per apical infections of the second and third mandible molars. Due to the rapid advancement of the clinical (which in certain occasions could even threaten the patient’s life) it is extremely important to know clearly the criteria for early diagnosis of Ludwig’s angina, which will enable us to provide the most appropriate treatment to halt the progress of the clinical and will prevent the onset of life-threatening complications.

Los profesionales que realizan los procedimientos de ortodoncia con mucha frecuencia utilizan fármacos para reducir o suprimir el dolor generado por el tratamiento ortodóntico, y así asegurar la continuidad del paciente al tratamiento impuesto. Dentro de dichos fármacos comúnmente utilizados tenemos a los Antiinflamatorios No Esteroideos (AINES), fármacos analgésicos no opioides, y analgésicos Opioides. Los AINES son fármacos que actúan mediante la inhibición de la enzima cicloxigenasa (COX), la cual está involucrada en la transformación de las prostaglandinas a partir del ácido araquidónico, dicha inhibición se puede dar en cualquiera de sus isoformas COX1 o COX2. La COX1 o constitutiva relacionada a favorecer procesos fisiológicos como en la homeostasia del hueso y la COX2 o inducida relacionada con procesos de dolor e inflamacion2. Tomando en cuenta que la mayoría de...

Evalúa el efecto de la prednisona, glucocorticoide de acción intermedia, y su efecto en el movimiento dentario ortodóntico en ratas. Se utilizan 20 ratas albinas machos Holtzman, a las cuales se les coloca un aparato ortodóntico disyuntor entre sus incisivos centrales superiores, luego son divididas de manera aleatoria en dos grupos: Grupo control, el cual no recibe ningún tratamiento farmacológico y grupo experimental, al cual se le administra prednisona 5 días antes de la colocación del aparato ortodóntico, así como también en los días 1, 3, 5 y 7 de colocado dicho aparato. Se determina la distancia interincisiva en los grupos experimental y control, así como también se realiza el conteo de osteoclastos en ambos grupos para evaluar la tasa de reabsorción ósea generada producto del movimiento inducido por el aparato ortodóntico. El grupo prednisona presenta menor distan...

Actualmente la estimulación del nervio vago es una estrategia terapéutica que se utiliza para el tratamiento de patologías neurológicas; sin embargo, ya se está considerando en otras patologías proinflamatorias por su modulación sobre las vías de interleucinas IL-1, IL-6 y TNF- α. Objetivo: la presente revisión temática tiene por objetivo conocer la evidencia científica disponible sobre el efecto inmunomodulador de la estimulación del nervio vago en artritis reumatoide como complemento al tratamiento actual de la enfermedad. Método: para su realización se desarrolló una búsqueda electrónica sin restricción de idioma, que comprenda los últimos 10 años en diferentes bases de datos: Medline, Web of Science, Scopus, Cochrane central, Lilacs, Embase, para recopilar estudios preclínicos y clínicos sobre el efecto inmunomodulador antiinflamatorio de la estimulación del n...

Introduction: The self-medication is the use of drugs without health professionals’ prescription that many times, instead of helping, aggravate the patient's health. Dental pain is the main reason for performing this act in the area of odontology. It is important to know if patients self-medicate in order to develop strategies to reduce the misuse of drugs and avoid this practice. Objective: Establish the frequency and characterization of self-medication in patients who visit to the three private dental clinics between the months of march to July in the year 2021. Materials and methods: Cross-sectional observational study with a sample of 450 patients from three dental clinics in the city of Lima. The assessment tool was a 13-question quiz about the main characteristics of self-medication. Results: The 85,8% of patients use drugs without medical prescription. 41.5% of the patients self...

Acute stress is related to the energetic release of catecholamines, cytokines, and cortisol, which trigger pain perception. Chewing stimulates serotonergic neurons, these neurons modulate the neural pathways of pain; however, the relationship between these variables is still in the process of understanding. Objective. To determine the effect of acute stress and chewing stimulus on pain. Methods. an experiment that was developed in the Faculty of Medicine of the UNMSM. 40 eight-week-old male Balb/c mice were randomly assigned into 5 equal groups. A: week 1 without any stimulus and week 2 chewing stimulus + stress. B: week 1 without any stimulus and week 2 stress. C: week 1 stress and week 2 without any stimulus. D: week 1 masticatory stimulus + stress and week 2 without any stimulus. E: control, without any stimulus. Pain was assessed in the 5 groups at 7 and 14 days using the tail-withdr...

Objetivos: Determinar el efecto del láser terapéutico infarrojo en la reparación ósea post exodoncia en ratas Albinas. Material y métodos: Treinta ratas Albinas Holtzman fueron divididos al azar en tres grupos (A, B y C) de 10 ratas cada uno de acuerdo al día de sacrifi cio y subdivididos en dos grupos teniendo 5 ratas cada uno (A1, A2, B1, B2, C1, C2). A los alvéolos de los incisivos superiores extraídos de las ratas de los grupos A1, B1 y C1 no se les aplicó el láser terapéutico infrarrojo siendo el control y a los alvéolos de las ratas de los grupos A2, B2 y C2 se les aplicó el láser terapéutico infrarrojo AsGaAl de forma puntual y continua. Las muestras se analizaron utilizando un Microscopio Óptico mediante conteo celular y estructuras nuevas del alvéolo. Resultados: A los 3 días se encontró una cantidad mayor de neutrófi los, linfocitos, macrófagos, fi broblast...

Trigeminal neuralgia (TN) is a painful neuropathic condition that involves one or more branches of the trigeminal nerve. The pain produced for the TN is described as a very intense acute pain, stabbing or shooting, as an electric shock that usually occurs of form unilateral and that goes all the way of the nerve involved. It is important to make the opportune diagnosis of the condition of TN for adequately differentiate of some odontogenic painful conditions and to prevent that the patient receive unnecessary treatment. The first line of treatment of the TN is the pharmacological therapy, in which is used as a drug of first choice to carbamazepine. The second line of treatment of TN is the non-pharmacological therapy, where include various options of surgical treatment: etiologic or symptomatic.

Trigeminal neuralgia (TN) is a painful neuropathic condition that involves one or more branches of the trigeminal nerve. The pain produced for the TN is described as a very intense acute pain, stabbing or shooting, as an electric shock that usually occurs of form unilateral and that goes all the way of the nerve involved. It is important to make the opportune diagnosis of the condition of TN for adequately differentiate of some odontogenic painful conditions and to prevent that the patient receive unnecessary treatment. The first line of treatment of the TN is the pharmacological therapy, in which is used as a drug of first choice to carbamazepine. The second line of treatment of TN is the non-pharmacological therapy, where include various options of surgical treatment: etiologic or symptomatic.

Objective. Evaluate the effect of zoledronic acid and hydroxocobalamin treatment on alveolar bone microarchitecture in mice with induced periodontitis and osteoporosis. Methods. Experimental design in preclinical phase. Sixteen female mice were included in which osteoporosis was induced by total ovariectomy and periodontitis was also induced by inflammation by 5/0 black silk ligation of the maxillary second molar, all protocols were performed under general anesthesia. The mice were distributed into 4 groups: control, treatment with zoledronic acid, treatment with hydroxocobalamin and combined treatment. At 16 weeks, euthanasia was performed, dissection was performed for evaluation by microtomography; determining bone mineral density (BMD), bone volume (BV/TV), trabecular thickness (Tb.Th), number of trabeculae (Tb.N), trabecular separation (Tb.Sp); descriptive and bivariate analysis was ...

The aim of this research was to compare systemic administration of azitromicin associated to root scaling and planning to the use of chlorhexidine mouth rinses associated to scaling and root planning, and scaling and root planning only for reducing probing depth and clinical attachment in adult patients with diagnosed of chronic periodontitis. For the trial 42 individuals with chronic periodontitis were selected, they were randomly distributed in three groups as follows: group A associated therapy of azitromicin with root scaling and planning; group B associated therapy with chlorhexidine and root scaling and planning; and group C root scaling and planning only. Probing depth and clinical attachment were recorded before treatment and every month for the next 6 months. The results showed better reduction in probing depth (before treatment: 5.70 ± 0.42 mm; during treatment: 1st month: 2.2...

El objetivo de la investigación fue comparar la eficacia de la administración sistémica de azitromicina asociada al raspaje y alisado radicular con la administración de enjuagatorios con clorhexidina asociados al raspaje y alisado radicular y con el tratamiento con sólo raspaje y alisado radicular, para reducir la profundidad de sondaje periodontal y mejorar los niveles de adherencia clínica en pacientes adultos con periodontitis crónica. Participaron 42 pacientes con periodontitis crónica, distribuidos aleatoriamente en tres grupos, siendo grupo A: azitromicina sistémica asociada a raspaje y alisado radicular; B: enjuagatorios con clorhexidina asociados al raspaje y alisado radicular; C: sólo raspaje y alisado radicular. Se evaluó la profundidad de sondaje periodontal y el nivel de adherencia clínica, antes de iniciar el tratamiento y luego cada mes durante los 6 meses poste...

Introduction. Acute stress alters memory and spatial learning and the expression of interleukin 6, the chewing stimulus would prevent these effects. Objective. To determine the effect of chewing stimulation and acute stress on the expression of interleukin 6 and memory and spatial learning in mice. Methods. Experiment where 70 male albino mice of the Balb/c of age 2 month were randomly distributed into: Group A1: acute stress 1 hour; Group A2: acute stress 1 hour + chewing stimulus 1 hour; Group B1: acute stress 2 hours; Group B2: acute stress 2 hours + chewing stimulus 2 hours; Group C1: acute stress 3 hours; C2: acute stress 3 hours + chewing stimulus 3 hours; Group D: without intervention. For 3 days, spatial memory and learning were tested in the Morris water maze. Interleukin 6 (IL-6) was analyzed by ELISA test. Results. IL-6 was higher in the B2 group vs the other groups (p<0.00...

The objective of this study was to determine the effects of diclofenac, etoricoxib, ibuprofen and paracetamol on the magnitude of orthodontic tooth movement. 50 Holtzman rats participated in 5 groups of 10 rats each. At the beginning of study the distance between the angles inciso-distals of both maxillary incisive was measured in each animal, using a caliper, and immediately an orthodontic device with a reciprocal action force of 35 g. was adhered to them. Each group received different treatments intraperitoneally (A: NaCl, control group, B: diclofenac, C: etoricoxib, D: ibuprofen, E: paracetamol) for 5 days. In all controls made the 1st, 3rd, 5th and 7th days, interincisive distance was significantly lower in the ibuprofen and diclofenac groups, without significant difference in the etoricoxib and paracetamol groups; all compared with control group. It was shown that administration of ...

El objetivo del presente estudio fue determinar los efectos de diclofenaco, etoricoxib, ibuprofeno y paracetamol sobre la magnitud del movimiento dentario ortodóntico. Participaron 50 ratas Holtzman distribuidas en 5 grupos de 10 ratas cada uno. Al inicio del trabajo, en cada uno de los animales, se midió la distancia entre los ángulos incisodistales de los incisivos maxilares empleando un calibrador, e inmediatamente se adhirió un dispositivo ortodóntico con una fuerza de acción recíproca de 35 g en dichos incisivos. Cada grupo recibió tratamientos diferentes por vía intraperitoneal (A: NaCl, grupo control, B: diclofenaco, C: etoricoxib, D: ibuprofeno, E: paracetamol) durante 5 días. En todos los controles hechos al 1er, 3er, 5to y 7mo día, la distancia interincisiva fue significativamente menor en los grupos ibuprofeno y diclofenaco, y sin diferencia significativa en los gru...