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artículo
La aplicación de las técnicas de la biología molecular y el éxito del Proyecto Genoma Humano ha abierto una nueva era tanto en Medicina como en Nutrición. Hasta la fecha, al menos, 1.000 genes humanos causantes de en fermedades han sido identificados y parcialmente carac terizados, el 97% de los cuales sabemos ahora que son causantes de enfermedades monogénicas. Sin embargo, otras patologías como la obesidad, enfermedad cardio vascular, diabetes, cáncer se deben a complejas interac ciones entre diversos genes y factores ambientales. A pe sar de los numerosos estudios de asociación, más de 600 publicados desde 2002, la base molecular de las enferme dades crónicas es todavía incierta. La información sobre polimorfismos de nucleótidos y mapas de haplotipos son recursos adicionales para identificar genes involucrados en enfermedades.
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artículo
Publicado 2020
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Objectives: To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis.Design, setting, and participants: A total of 278 retinoblastoma treatment centers were recruited from June 2017 through December 2018 to participate in a cross-sectional analysis of treatment-naive patients with retinoblastoma who were diagnosed in 2017. Main outcomes and measures: Age at presentation, proportion of familial history of retinoblastoma, and tumor stage and metastasis.Results: The cohort included 4351 new patients from 153 countries; the median age at diagnosis was 30.5 (interquartile range, 18.3-45.9) months, and 1976 patients (45.4%) were female. Most patients (n = 3685 [84.7%]) were from low- and middle-income count...
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artículo
Publicado 2012
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The use of satellite imagery to assess river sediment discharge is discussed in the context of poorly monitored basins. For more than three decades, the Peruvian hydrological service SENAMHI has been maintaining several gauging stations in the lower part of the Amazon River catchment. This network has been recently supplemented by the Hydro-geodynamics of the Amazon Basin (HYBAM) program, which has a water quality monitoring network distributed over five locations and allows the assessment of river discharge and surface suspended sediment (SSS) concentration. In this paper, the three stations that are located near the confluence of the Marañon and Ucayali Rivers, which form the Amazon River, are reviewed in detail. Two of the stations provide a complete time series of 10-day SSS samples over the studied period. The third station, along the Ucayali River, failed to provide valid estimate...
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artículo
Publicado 2021
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This research was funded by Fondo Nacional de Desarrollo Cient?fico, Tecnol?gico y de Innovaci?n Tecnol?gica (FONDECYT) del Consejo Nacional de Ciencia Tecnolog?a e Innovaci?n Tecnol?gica (CONCYTEC) del Gobierno de Per? (Convenio de Subvenci?n 153-2015-FONDECYT). The authors would like to thank Dr. Pedro Alva-Plasencia, principal researcher of the project PIC 06-2014, for providing the laboratory equipment.
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artículo
Publicado 2018
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In Ecuador and Peru, geochemical information from Pacific coastal rivers is limited and scarce. Here, we present an unedited database of major element concentrations from five HYBAM observatory stations monitored monthly between 4 and 10 years, and the discrete sampling of 23 Andean rivers distributed along the climate gradient of the Ecuadorian and Peruvian Pacific coasts. Concentration (C) vs. discharge (Q) relationships of the five monitored basins exhibit a clear dilution behavior for evaporites and/or pyrite solutes, while the solute concentrations delivered by other endmembers are less variable. Spatially, the annual specific fluxes for total dissolved solids (TDS), Ca2+, HCO3 −, K+, Mg2+, and SiO2 are controlled on the first order by runoff variability, while Cl−, Na+ and SO4 2− are controlled by the occurrence of evaporites and/or pyrite. The entire Pacific basin in Ecuador...
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artículo
Publicado 2014
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Formation of mountain ranges results from complex coupling between lithospheric deformation, mechanisms linked to subduction and surface processes: weathering, erosion, and climate. Today, erosion of the eastern Andean cordillera and sub-Andean foothills supplies over 99% of the sediment load passing through the Amazon Basin. Denudation rates in the upper Ucayali basin are rapid, favoured by a marked seasonality in this region and extreme precipitation cells above sedimentary strata, uplifted during Neogene times by a still active sub-Andean tectonic thrust. Around 40% of those sediments are trapped in the Ucayali retro-foreland basin system. Recent advances in remote sensing for Amazonian large rivers now allow us to complete the ground hydrological data. In this work, we propose a first estimation of the erosion and sedimentation budget of the Ucayali River catchment, based on spatial ...
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objeto de conferencia
Publicado 2014
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Formation of mountain ranges results from complex coupling between lithospheric deformation, mechanisms linked to subduction and surface processes: weathering, erosion, and climate. Today, erosion of the eastern Andean cordillera and sub-Andean foothills supplies over 99% of the sediment load passing through the Amazon Basin. Denudation rates in the upper Ucayali basin are rapid, favoured by a marked seasonality in this region and extreme precipitation cells above sedimentary strata, uplifted during Neogene times by a still active sub-Andean tectonic thrust. Around 40% of those sediments are trapped in the Ucayali retro-foreland basin system. Recent advances in remote sensing for Amazonian large rivers now allow us to complete the ground hydrological data. In this work, we propose a first estimation of the erosion and sedimentation budget
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artículo
Publicado 2016
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The aim of the present study is to estimate the export fluxes of major dissolved species at the scale of the Amazon basin, to identify the main parameters controlling their spatial distribution and to identify the role of discharge variability in the variability of the total dissolved solid (TDS) flux through the hydrological cycle. Data are compiled from the monthly hydrochemistry and daily discharge database of the “Programa Climatologico y Hidrologico de la Cuenca Amazonica de Bolivia” (PHICAB) and the HYBAM observatories from 34 stations distributed over the Amazon basin (for the 1983–1992 and 2000–2012 periods, respectively). This paper consists of a first global observation of the fluxes and temporal dynamics of each geomorphological domain of the Amazon basin. Based on mean interannual monthly flux calculations, we estimated that the Amazon basin delivered approximately 27...
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artículo
Publicado 2019
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Pineapple peels has several beneficial properties including antioxidant activity. We investigated the antioxidant effect of five different peels of pineapple lyophilized extracts, not adsorbed and adsorbed onto Amberlite. They were examined using total phenolic contents (TPC), antioxidant effect by 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging and ferric reducing antioxidant power (FRAP). In addition, we analyzed the chemical composition by HPLC-ESI-QTOF-MS/MS. The main constituents of pineapple peels were tentatively identified as quercetin glycosides and N,N’-diferuloylspermidine. We conclude that the antioxidant activity in pineapple peels from District of Poroto, Province of Trujillo, Region of La Libertad, can be associated with the presence of flavonoid and spermidines. © 2019, Universidad de Santiago de Chile. All rights reserved.
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artículo
Publicado 2019
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Because increasing climatic variability and anthropic pressures have affected the sediment dynamics of large tropical rivers, long-term sediment concentration series have become crucial for understanding the related socioeconomic and environmental impacts. For operational and cost rationalization purposes, index concentrations are often sampled in the flow and used as a surrogate of the cross-sectional average concentration. However, in large rivers where suspended sands are responsible for vertical concentration gradients, this index method can induce large uncertainties in the matter fluxes. Assuming that physical laws describing the suspension of grains in turbulent flow are valid for large rivers, a simple formulation is derived to model the ratio (α) between the depth-averaged and index concentrations. The model is validated using an exceptional dataset (1330 water samples, 249 con...
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artículo
Publicado 2012
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The aim of this study is to evaluate the ability of the ORCHIDEE land surface model to simulate streamflows over each sub-basin of the Amazon River basin. For this purpose, simulations are performed with a routing module including the influence of floodplains and swamps on river discharge and validated against on-site hydrological measurements collected within the HYBAM observatory over the 1980-2000 period. When forced by the NCC global meteorological dataset, the initial version of ORCHIDEE shows discrepancies with ORE HYBAM measurements with underestimation by 15% of the annual mean streamflow at Óbidos hydrological station. Consequently, several improvements are incrementally added to the initial simulation in order to reduce those discrepancies. First, values of NCC precipitation are substituted by ORE HYBAM daily in-situ rainfall observations from the meteorological services of Am...
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artículo
Publicado 2024
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South America’s hydroclimate sustains vibrant communities and natural ecosystems of extraordinary biodiversity including the Andes Cordillera, and the Orinoco, La Plata, and Amazon basins. Global warming and land-use change are endangering ecosystem health, exacerbating hydrometeorological extremes, and threatening water and food security for millions of people on the continent (Castellanos et al. 2022). Reductions in rainfall and streamflow have been observed in southern Amazonia, the Cerrado region, northeast Brazil, and Chile (Muñoz et al. 2020; Garreaud et al. 2020; Espinoza et al. 2019; Fu et al. 2013). The increased aridity has affected agricultural yield, water supply for reservoirs, hydropower generation and impacted tens of millions of people in the large metropolitan areas of Sao Paulo, Rio de Janeiro, and Santiago de Chile (Nobre et al. 2016). Andean glaciers, an important ...
