Antecedentes: Es esencial entender los factores ambientales y humanos que contribuyen a la presencia de gametocitos para un adecuado diseño de las intervenciones destinadas a la eliminación de la malaria; pero en las zonas de baja transmisión y alta prevalencia de P. vivax, que se caracteriza por infecciones de baja densidad, el uso de herramientas moleculares ha permitido detectar más de 90% de infecciones con gametocitos en casos de malaria, a diferencia de la microscopía que no es un método apropiado de diagnóstico para detectar la presencia de infecciones sub-microscópicas de estadios asexuales y gametocitos . Objetivo: Identificar factores ambientales y humanos asociados a la presencia de gametocitos en áreas de baja transmisión en la Amazonia Peruana mediante métodos de detección molecular. Materiales y Métodos: Se realizó un estudio longitudinal de Diciembre 2013 has...

Among the most frequent malignancies worldwide, hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death (1). Its incidence has doubled over the past two decades, with the greatest burden occurring in low- and middle-income countries. Malignant primary liver tumors are usually described as a pathology affecting mainly men older than 40 years with a cirrhotic liver; they have rarely been reported in younger people and usually, in those younger than 40, most commonly hepatoblastoma.

Plasmodium vivax es un desafío para la eliminación de la malaria. Esta especie cuenta con un estadío hepático latente (Hipnozoíto) que mantiene la transmisión de la enfermedad. El proyecto SEROVIVAX tiene como objetivo contribuir a la eliminación de la malaria en la región amazónica a través del desarrollo y validación de herramientas serológicas que permitan identificar la exposición individual reciente a P. vivax y monitorear los cambios en la intensidad de transmisión. Usando microarreglos de proteínas se evaluó las respuestas de anticuerpos a 507 proteínas de P. vivax en 207 individuos infectados en los últimos 36 meses y confirmados por qPCR (P. vivax positivos). El área bajo la curva (AUC), sensibilidad (SE), especificidad (SP), razones de probabilidad positiva (LR+) y negativa (LR-) fueron calculados a partir de un modelo de clasificación validados, a fin de ev...

Background: Faced with the resurgence of malaria in the Peruvian Amazon since 2012, malaria surveillance was enhanced by adding a local active case detection (ACD) strategy to the routine passive case detection (PCD) as a reactive measure in selected communities with unusual number of cases during high transmission season (HTS). We assessed the short-effectiveness of this local ACD-based strategy in four Peruvian Amazonian riverine communities. Methods: A cohort study was conducted in June-July 2015 in Mazan, Loreto. Four consecutive ACD interventions (using light microscopy (LM) and treatment of confirmed infections) at intervals of 10 days were conducted in four riverine communities (Gamitanacocha-GAM, Primero de Enero-PRI, Libertad-LIB, and Urco Miraño-URC) that previously reported unusual number of cases. Blood samples were also collected on filter paper for later PCR. The effective...

Plasmodium vivax is the main cause of malaria in the Peruvian Amazon and Mazan is considered one of its districts with high risk of malaria transmission. In this site, previous studies has described P. vivax transmission as heterogenic and has suggested that its prevalence is influenced by factors linked to human mobilization. However, the contribution of this factor have not been assessed yet. Population genetic tools provide information on the individual contribution of the factors that favor the transmission and evaluate the demographic patterns of dispersion of the parasite populations which are influenced by the human mobilization. In order to evaluate contribution of human mobilization to malariatransmission in Mazan, in this work we use a Bayesian framework to identify genetic sub-populations in each basin and to discriminate between endogenous and imported cases. Socio-demographi...

This work was supported by the Consejo Nacional de Ciencia, Tecnologia e Innovacion Tecnologica (grant number 008-2014-FONDECYT); the Academie de Recherche et d'Enseignement Superieur-Commission de la Cooperation au Developpement of Belgium (grant number ARES-CCD, PRD-Peru 2014-2019 to N. S., A. L. C., and A. R. A.); World Health Organization Special Programme for Research and Training in Tropical Diseases (grant number 201460655 to D. G.); and National Institutes of Health, National Institute of Allergy and Infectious Diseases (grant numbers U19AI089681 to J. M. V. and R01AI110112 to J. E. C.). A. R. A. is a Postdoctoral Researcher of the Fonds de la Recherche Scientifique (FNRS, Belgium).