Introducción: En la Amazonía Peruana, la transmisión de la malaria por Plasmodium vivax se mantiene debido a que 1) las recurrencias en esta región son extremadamente comunes; contribuyendo al incremento de los casos submicroscópicos y 2) porque estas infecciones no son detectadas por el Ministerio de Salud, perpetuando así el ciclo de transmisión silente. En este contexto, entender las características y duración de estas infecciones recurrentes submicroscópicas nos permitiría comprender su impacto en la persistencia de la malaria. Métodos: Se realizó un análisis retrospectivo de datos clínicos y epidemiológicos mensuales de dos comunidades de Loreto (Cahuide y Lupuna) desde el año 2013 al 2015. Los participantes proporcionaron muestras de sangre para el diagnóstico de la malaria a través de microscopía y PCR (método molecular). Para determinar la probabilidad de per...

Although there were a reduction in malaria burden, with 30% fewer cases in 2018 than in 2014, malaria remains a major public health problem in Peru, mainly in the Amazon region where over 44,000 cases were reported in 2018 (96% of cases in the country). Plasmodium vivax is the predominant species, representing 75.5% of malaria cases, similar to the rest of the region of the Americas. P. vivax infections are characterized by frequent relapses due to persistent liver dormant parasites. Previous studies of our research group in the Peruvian Amazon have shown high proportion of recurrence after radical cure (~75% in one year of follow-up [1]). This study aimed to describe the evolution of parasitemia after a supervised radical cure treatment in an endemic rural village in the Peruvian Amazon follow-up by both, molecular tools (qPCR) and thick smear, during one month.

The incidence of malaria due both to Plasmodium falciparum and Plasmodium vivax in the Peruvian Amazon has risen in the past 5 years. This study tested the hypothesis that the maintenance and emergence of malaria in hypoendemic regions such as Amazonia is determined by submicroscopic and asymptomatic Plasmodium parasitaemia carriers. The present study aimed to precisely quantify the rate of very-low parasitaemia carriers in two sites of the Peruvian Amazon in relation to transmission patterns of P.vivax and P.falciparum in this area. Methods: This study was carried out within the Amazonian-ICEMR longitudinal cohort. Blood samples were collected for light microscopy diagnosis and packed red blood cell (PRBC) samples were analysed by qPCR. Plasma samples were tested for total IgG reactivity against recombinant PvMSP-10 and PfMSP-10 antigens by ELISA. Occupation and age 10 years and greater...

Tiene como objetivo recopilar información de referencia sobre la bionomía de los vectores de la malaria y los factores de riesgo de transmisión de 4 sitios en un área de malaria hiperendémica.

Background: Faced with the resurgence of malaria in the Peruvian Amazon since 2012, malaria surveillance was enhanced by adding a local active case detection (ACD) strategy to the routine passive case detection (PCD) as a reactive measure in selected communities with unusual number of cases during high transmission season (HTS). We assessed the short-effectiveness of this local ACD-based strategy in four Peruvian Amazonian riverine communities. Methods: A cohort study was conducted in June-July 2015 in Mazan, Loreto. Four consecutive ACD interventions (using light microscopy (LM) and treatment of confirmed infections) at intervals of 10 days were conducted in four riverine communities (Gamitanacocha-GAM, Primero de Enero-PRI, Libertad-LIB, and Urco Miraño-URC) that previously reported unusual number of cases. Blood samples were also collected on filter paper for later PCR. The effective...

This work was supported by the Consejo Nacional de Ciencia, Tecnologia e Innovacion Tecnologica (grant number 008-2014-FONDECYT); the Academie de Recherche et d'Enseignement Superieur-Commission de la Cooperation au Developpement of Belgium (grant number ARES-CCD, PRD-Peru 2014-2019 to N. S., A. L. C., and A. R. A.); World Health Organization Special Programme for Research and Training in Tropical Diseases (grant number 201460655 to D. G.); and National Institutes of Health, National Institute of Allergy and Infectious Diseases (grant numbers U19AI089681 to J. M. V. and R01AI110112 to J. E. C.). A. R. A. is a Postdoctoral Researcher of the Fonds de la Recherche Scientifique (FNRS, Belgium).