La presente invención está relacionada a péptidos y métodos para la detección de anticuerpos anti-leishmania en individuos sospechosos de infección con el protozoo parásito del género Leishmania, especialmente la infección con una cepa sudamericana causante de la Leishmaniasis Tegumentaria (ATL)

La presente invención se refiere a péptidos y métodos para la detección de anticuerpos anti-leishmania en individuos sospechosos de estar infectados por el parásito protozoario del género Leishmania, especialmente la infección por una cepa sudamericana causante de la leishmaniasis tegumentaria americana (LTA).

La presente invención se refiere a péptidos y métodos para la detección de anticuerpos anti-leishmania en individuos sospechosos de infección por el parásito protozoario del género Leishmania, especialmente infección por una cepa sudamericana causante de la Leishmaniasis Tegumentaria Americana (ATL).

La presente invención está relacionada a péptidos y métodos para la detección de anticuerpos anti-leishmania en individuos sospechosos de infección con el protozoo parásito del género Leishmania, especialmente la infección con una cepa sudamericana causante de la Leishmaniasis Tegumentaria Americana (ATL)

La presente invención se refiere a péptidos y métodos para la detección de anticuerpos anti-leishmania en individuos sospechosos de infección por el parásito protozoario del género Leishmania, en especial infección por South Cepa americana causante de la leishmaniasis tegumentaria americana (ATL).

Peptídeos e métodos para a detecção de leishmaniose. A presente invenção refere-se a peptídeos e métodos para a detecção de anticorpos anti-leishmaniose em indivíduos suspeitos de infecção com o protozoário parasita do gênero Leishmania, especialmente a infecção com uma estirpe Sul Americana causando a Leishmaniose Americana Tegumentar (ATL).

Among the most frequent malignancies worldwide, hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death (1). Its incidence has doubled over the past two decades, with the greatest burden occurring in low- and middle-income countries. Malignant primary liver tumors are usually described as a pathology affecting mainly men older than 40 years with a cirrhotic liver; they have rarely been reported in younger people and usually, in those younger than 40, most commonly hepatoblastoma.

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: TRR was a recipient of a doctoral fellowship from Innóvate Perú (069-FINCyT-BDE-2014); JPC was a recipient of a doctoral fellowship from the Peruvian National Council for Science and Technology (212-2015-FONDECYT); ER and FD were supported by the Young Research Teams Associated with IRD Program (JEAI-INCAncer); and GB, PP, JG, ED, and SB were supported by the Third Cancer Plan of the French National Alliance for Life Sciences and Health (ENV201408).

This study was funded by the French National League against Cancer (team label LNCC) and Odyssey-RE; E.D., S.B., and P.P. were supported by the Third Cancer Plan, ITMO Cancer of the French National Alliance for Life Sciences and Health (ENV201408); J.P.C. was a recipient of a doctoral fellowship from the Peruvian National Council for Science and Technology (212-2015-FONDECYT); L.C. was a recipient of a doctoral fellowship from French National Research Institute for Sustainable Development (IRD) (EMHE-ARTS-2016-878573B); and L.C., E.R., and S.C. were supported by the Young Research Teams Associated with IRD Program (INCAncer). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors wish to acknowledge all patients whose participation was essential to the achievement of this study. The authors are grateful to...

We previously described a divergent clinical and molecular presentation of hepatocellular carcinoma (HCC) in Peru. The present study aimed to further characterize the tissue features associated with this singular nosological form of HCC in order to gain insight into the natural history of the disease. We performed an exploratory analysis of the histology of both tumor and non-tumor liver (NTL) tissues from 50 Peruvian HCC patients, and compared with that of 75 individuals with non-HCC liver tumor or benign liver lesions as a baseline for NTL features. We complemented this approach with a transcriptome analysis in a subset of NTL tissue samples and also performed an ultra-sensitive hepatitis B virus (HBV) detection in liver tissues of the patients. Overall, results highlighted the low rate of liver parenchymal alterations in a young patient cohort (median age: 40 years old), despite a str...

Malaria, babesiosis, trypanosomosis, and leishmaniasis are some of the most life-threatening parasites, but the range of drugs to treat them is limited. An effective, safe, and low-cost drug with a large activity spectrum is urgently needed. For this purpose, an aryl amino alcohol derivative called Alsinol was resynthesized, screened in silico, and tested against Plasmodium, Babesia, Trypanosoma, and Leishmania. In silico Alsinol follows the Lipinski and Ghose rules. In vitro it had schizontocidal activity against Plasmodium falciparum and was able to inhibit gametocytogenesis; it was particularly active against late gametocytes. In malaria-infected mice, it showed a dose-dependent activity similar to chloroquine. It demonstrated a similar level of activity to reference compounds against Babesia divergens, and against promastigotes, and amastigotes stages of Leishmania in vitro. It inhib...