We describe here the isolation of 6 xanthones and one phenyl-γ-pyrone, together with 3-epibetulinic and quercetine from the aerial parts of Hypericum laricifolium Juss. (Hypericaceae), collected in Peru. Isolated compounds have been evaluated against proliferation of human hepatocellular carcinoma Hep3B cells. The most active compound was xanthone 3, with an inhibitory concentration (IC50) of 12 µM.

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: TRR was a recipient of a doctoral fellowship from Innóvate Perú (069-FINCyT-BDE-2014); JPC was a recipient of a doctoral fellowship from the Peruvian National Council for Science and Technology (212-2015-FONDECYT); ER and FD were supported by the Young Research Teams Associated with IRD Program (JEAI-INCAncer); and GB, PP, JG, ED, and SB were supported by the Third Cancer Plan of the French National Alliance for Life Sciences and Health (ENV201408).