Early-onset liver cancer in South America associates with low hepatitis B virus DNA burden

• Autores: Marchio, Agnès, Cerapio, Juan Pablo, Ruiz, Eloy, Cano, Luis, Casavilca, Sandro, Terris, Benoît, Deharo, Eric, Dejean, Anne, Bertani, Stéphane, Pineau, Pascal
• Formato: artículo
• Fecha de Publicación: 2018
• Institución: Consejo Nacional de Ciencia Tecnología e Innovación
• Repositorio: CONCYTEC-Institucional
• Lenguaje: inglés
• OAI Identifier: oai:repositorio.concytec.gob.pe:20.500.12390/2761
• Enlace del recurso: https://hdl.handle.net/20.500.12390/2761; https://doi.org/10.1038/s41598-018-30229-8
• Nivel de acceso: acceso abierto
• Materia: Hepatitis B virus; chronic hepatitis B; DNA repair; female; genetics; http://purl.org/pe-repo/ocde/ford#3.04.03

This study was funded by the French National League against Cancer (team label LNCC) and Odyssey-RE; E.D., S.B., and P.P. were supported by the Third Cancer Plan, ITMO Cancer of the French National Alliance for Life Sciences and Health (ENV201408); J.P.C. was a recipient of a doctoral fellowship from the Peruvian National Council for Science and Technology (212-2015-FONDECYT); L.C. was a recipient of a doctoral fellowship from French National Research Institute for Sustainable Development (IRD) (EMHE-ARTS-2016-878573B); and L.C., E.R., and S.C. were supported by the Young Research Teams Associated with IRD Program (INCAncer). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors wish to acknowledge all patients whose participation was essential to the achievement of this study. The authors are grateful to Karina Cancino, Dany Cordova, Franco Doimi, Macarena Farías, and Maricarmen Valera from the Cancer Research Biobank of the Department of Pathology of INEN for their leadership in aggregating the medical records and collecting the biomedical specimens. We thank Damien Mornico for his considerable help in viral sequence submissions and Lucas Robinson for his valuable editorial assistance.