Early-onset liver cancer in South America associates with low hepatitis B virus DNA burden
Descripción del Articulo
This study was funded by the French National League against Cancer (team label LNCC) and Odyssey-RE; E.D., S.B., and P.P. were supported by the Third Cancer Plan, ITMO Cancer of the French National Alliance for Life Sciences and Health (ENV201408); J.P.C. was a recipient of a doctoral fellowship fro...
| Autores: | , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de Publicación: | 2018 |
| Institución: | Consejo Nacional de Ciencia Tecnología e Innovación |
| Repositorio: | CONCYTEC-Institucional |
| Lenguaje: | inglés |
| OAI Identifier: | oai:repositorio.concytec.gob.pe:20.500.12390/2761 |
| Enlace del recurso: | https://hdl.handle.net/20.500.12390/2761 https://doi.org/10.1038/s41598-018-30229-8 |
| Nivel de acceso: | acceso abierto |
| Materia: | Hepatitis B virus chronic hepatitis B DNA repair female genetics http://purl.org/pe-repo/ocde/ford#3.04.03 |
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| dc.title.none.fl_str_mv |
Early-onset liver cancer in South America associates with low hepatitis B virus DNA burden |
| title |
Early-onset liver cancer in South America associates with low hepatitis B virus DNA burden |
| spellingShingle |
Early-onset liver cancer in South America associates with low hepatitis B virus DNA burden Marchio, Agnès Hepatitis B virus chronic hepatitis B DNA repair female genetics http://purl.org/pe-repo/ocde/ford#3.04.03 |
| title_short |
Early-onset liver cancer in South America associates with low hepatitis B virus DNA burden |
| title_full |
Early-onset liver cancer in South America associates with low hepatitis B virus DNA burden |
| title_fullStr |
Early-onset liver cancer in South America associates with low hepatitis B virus DNA burden |
| title_full_unstemmed |
Early-onset liver cancer in South America associates with low hepatitis B virus DNA burden |
| title_sort |
Early-onset liver cancer in South America associates with low hepatitis B virus DNA burden |
| author |
Marchio, Agnès |
| author_facet |
Marchio, Agnès Cerapio, Juan Pablo Ruiz, Eloy Cano, Luis Casavilca, Sandro Terris, Benoît Deharo, Eric Dejean, Anne Bertani, Stéphane Pineau, Pascal |
| author_role |
author |
| author2 |
Cerapio, Juan Pablo Ruiz, Eloy Cano, Luis Casavilca, Sandro Terris, Benoît Deharo, Eric Dejean, Anne Bertani, Stéphane Pineau, Pascal |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Marchio, Agnès Cerapio, Juan Pablo Ruiz, Eloy Cano, Luis Casavilca, Sandro Terris, Benoît Deharo, Eric Dejean, Anne Bertani, Stéphane Pineau, Pascal |
| dc.subject.none.fl_str_mv |
Hepatitis B virus |
| topic |
Hepatitis B virus chronic hepatitis B DNA repair female genetics http://purl.org/pe-repo/ocde/ford#3.04.03 |
| dc.subject.es_PE.fl_str_mv |
chronic hepatitis B DNA repair female genetics |
| dc.subject.ocde.none.fl_str_mv |
http://purl.org/pe-repo/ocde/ford#3.04.03 |
| description |
This study was funded by the French National League against Cancer (team label LNCC) and Odyssey-RE; E.D., S.B., and P.P. were supported by the Third Cancer Plan, ITMO Cancer of the French National Alliance for Life Sciences and Health (ENV201408); J.P.C. was a recipient of a doctoral fellowship from the Peruvian National Council for Science and Technology (212-2015-FONDECYT); L.C. was a recipient of a doctoral fellowship from French National Research Institute for Sustainable Development (IRD) (EMHE-ARTS-2016-878573B); and L.C., E.R., and S.C. were supported by the Young Research Teams Associated with IRD Program (INCAncer). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors wish to acknowledge all patients whose participation was essential to the achievement of this study. The authors are grateful to Karina Cancino, Dany Cordova, Franco Doimi, Macarena Farías, and Maricarmen Valera from the Cancer Research Biobank of the Department of Pathology of INEN for their leadership in aggregating the medical records and collecting the biomedical specimens. We thank Damien Mornico for his considerable help in viral sequence submissions and Lucas Robinson for his valuable editorial assistance. |
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2018 |
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2024-05-30T23:13:38Z |
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2024-05-30T23:13:38Z |
| dc.date.issued.fl_str_mv |
2018 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12390/2761 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1038/s41598-018-30229-8 |
| dc.identifier.scopus.none.fl_str_mv |
2-s2.0-85051679223 |
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https://hdl.handle.net/20.500.12390/2761 https://doi.org/10.1038/s41598-018-30229-8 |
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2-s2.0-85051679223 |
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eng |
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eng |
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Scientific Reports |
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info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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https://creativecommons.org/licenses/by/4.0/ |
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Nature Publishing Group |
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Nature Publishing Group |
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reponame:CONCYTEC-Institucional instname:Consejo Nacional de Ciencia Tecnología e Innovación instacron:CONCYTEC |
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Publicationrp05747600rp05750600rp05755600rp05751600rp06445600rp07391600rp01885600rp05749600rp05752600rp05756600Marchio, AgnèsCerapio, Juan PabloRuiz, EloyCano, LuisCasavilca, SandroTerris, BenoîtDeharo, EricDejean, AnneBertani, StéphanePineau, Pascal2024-05-30T23:13:38Z2024-05-30T23:13:38Z2018https://hdl.handle.net/20.500.12390/2761https://doi.org/10.1038/s41598-018-30229-82-s2.0-85051679223This study was funded by the French National League against Cancer (team label LNCC) and Odyssey-RE; E.D., S.B., and P.P. were supported by the Third Cancer Plan, ITMO Cancer of the French National Alliance for Life Sciences and Health (ENV201408); J.P.C. was a recipient of a doctoral fellowship from the Peruvian National Council for Science and Technology (212-2015-FONDECYT); L.C. was a recipient of a doctoral fellowship from French National Research Institute for Sustainable Development (IRD) (EMHE-ARTS-2016-878573B); and L.C., E.R., and S.C. were supported by the Young Research Teams Associated with IRD Program (INCAncer). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors wish to acknowledge all patients whose participation was essential to the achievement of this study. The authors are grateful to Karina Cancino, Dany Cordova, Franco Doimi, Macarena Farías, and Maricarmen Valera from the Cancer Research Biobank of the Department of Pathology of INEN for their leadership in aggregating the medical records and collecting the biomedical specimens. We thank Damien Mornico for his considerable help in viral sequence submissions and Lucas Robinson for his valuable editorial assistance.In Peru, hepatocellular carcinoma (HCC) arises in young non-cirrhotic patients. Hepatitis B virus (HBV) is suspected to be the prominent etiological agent. We thus performed a comprehensive molecular study of HBV infection in 65 Peruvian HCC patients. Only 51% were considered as persistently infected at the onset. HBV DNA was found by PCR in the tumor and/or matched non-tumor liver tissues in more than 80% of cases (n = 53/65). HBV DNA was significantly more abundant in livers of younger patients than in those of the older ones. We consistently observed low viral DNA burden (0.1–6.5 copies for 100 cells), with viral genomes in younger patients displaying higher proportion of mutations at di-pyrimidines (TpT and CpC, P = 0.006). A drastic activation of multiple DNA repair pathways in tumors of younger patients was observed. Our observations clearly challenge the current vision that associates high HBV DNA load with earlier tumor development. We concluded that in Peru, and maybe in other populations with Americas’ indigenous ancestry, HBV-associated liver tumorigenesis might differ significantly from that generally observed in the rest of the world. Procedures used to screen for HCC development in subjects at risk should be adapted to the local situation. © 2018, The Author(s).Fondo Nacional de Desarrollo Científico y Tecnológico - FondecytengNature Publishing GroupScientific Reportsinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/4.0/Hepatitis B viruschronic hepatitis B-1DNA repair-1female-1genetics-1http://purl.org/pe-repo/ocde/ford#3.04.03-1Early-onset liver cancer in South America associates with low hepatitis B virus DNA burdeninfo:eu-repo/semantics/articlereponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#ORIGINALs41598-018-30229-8.pdfs41598-018-30229-8.pdfapplication/pdf5437187https://repositorio.concytec.gob.pe/bitstreams/cf133216-7ec7-488a-a9e6-a4a6ab8c0d26/downloadf2cc52dc1c172378c1b9b41c31ade165MD51TEXTs41598-018-30229-8.pdf.txts41598-018-30229-8.pdf.txtExtracted texttext/plain56047https://repositorio.concytec.gob.pe/bitstreams/0e3ae1c0-3ca6-4b61-97da-3b4898ab52dd/downloade71462bd0bc1f5c1e40dfdc03e530690MD52THUMBNAILs41598-018-30229-8.pdf.jpgs41598-018-30229-8.pdf.jpgGenerated Thumbnailimage/jpeg6470https://repositorio.concytec.gob.pe/bitstreams/716dcc2f-0fd2-4d13-b03f-d5a31776573a/download5d348adb6eff1d43aefc67f97aaead49MD5320.500.12390/2761oai:repositorio.concytec.gob.pe:20.500.12390/27612025-01-14 22:00:22.057https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessopen accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="1cff3c8c-06d5-4515-8479-accbfef04ab6"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Early-onset liver cancer in South America associates with low hepatitis B virus DNA burden</Title> <PublishedIn> <Publication> <Title>Scientific Reports</Title> </Publication> </PublishedIn> <PublicationDate>2018</PublicationDate> <DOI>https://doi.org/10.1038/s41598-018-30229-8</DOI> <SCP-Number>2-s2.0-85051679223</SCP-Number> <Authors> <Author> <DisplayName>Marchio, Agnès</DisplayName> <Person id="rp05747" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Cerapio, Juan Pablo</DisplayName> <Person id="rp05750" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Ruiz, Eloy</DisplayName> <Person id="rp05755" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Cano, Luis</DisplayName> <Person id="rp05751" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Casavilca, Sandro</DisplayName> <Person id="rp06445" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Terris, Benoît</DisplayName> <Person id="rp07391" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Deharo, Eric</DisplayName> <Person id="rp01885" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Dejean, Anne</DisplayName> <Person id="rp05749" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Bertani, Stéphane</DisplayName> <Person id="rp05752" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Pineau, Pascal</DisplayName> <Person id="rp05756" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Nature Publishing Group</DisplayName> <OrgUnit /> </Publisher> </Publishers> <License>https://creativecommons.org/licenses/by/4.0/</License> <Keyword>Hepatitis B virus</Keyword> <Keyword>chronic hepatitis B</Keyword> <Keyword>DNA repair</Keyword> <Keyword>female</Keyword> <Keyword>genetics</Keyword> <Abstract>In Peru, hepatocellular carcinoma (HCC) arises in young non-cirrhotic patients. Hepatitis B virus (HBV) is suspected to be the prominent etiological agent. We thus performed a comprehensive molecular study of HBV infection in 65 Peruvian HCC patients. Only 51% were considered as persistently infected at the onset. HBV DNA was found by PCR in the tumor and/or matched non-tumor liver tissues in more than 80% of cases (n = 53/65). HBV DNA was significantly more abundant in livers of younger patients than in those of the older ones. We consistently observed low viral DNA burden (0.1–6.5 copies for 100 cells), with viral genomes in younger patients displaying higher proportion of mutations at di-pyrimidines (TpT and CpC, P = 0.006). A drastic activation of multiple DNA repair pathways in tumors of younger patients was observed. Our observations clearly challenge the current vision that associates high HBV DNA load with earlier tumor development. We concluded that in Peru, and maybe in other populations with Americas’ indigenous ancestry, HBV-associated liver tumorigenesis might differ significantly from that generally observed in the rest of the world. Procedures used to screen for HCC development in subjects at risk should be adapted to the local situation. © 2018, The Author(s).</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1 |
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Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
