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1
artículo
Publicado 2015
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Biosafety tests were conducted on albino mice (NMRI strain) to evaluate pathogenic effects of a native isolate LF14 of B. bassiana, highly virulent to Rhodnius prolixus and Triatoma maculata (Triatominae), vectors of Chagas disease in Venezuela. A total of 1x109 conidias/ml of the fungus was administered to the animals by nasal drops. Body weight control and clinical and behavioural evaluations were done daily. Likewise, clearance of fungus was estimated by direct examination and culturing of intranasal samples, and infectivity by performing mycological and histopathological test after necropsies at 3, 7 and 14 days post-inoculation. Animals no showed discernible pathological changes or death and all had active-normal behaviour. Body weight increased in both treated and control mice groups, with statistically difference between sexes (p<0.0000). Anatomopathological changes were not de...
2
artículo
Publicado 2016
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The objective of this article was to investigate the effects of chronic exposure to magnetic fields (MC) of existing environmental levels in the city of Lima on the reproductive health of male mice. Firstly, the information on the levels of the magnetic fields of electric power lines measured in Peru and other countries as well as the exposure limits of the international commission for protection against electromagnetic fields (ICNIRP) were reviewed to define the levels to which it would be exposed to biological material. The biological sample was 32 10-week-old male mice (Mus musculus) of the Balb C strain, with which four experimental groups of 8 mice each were formed, including a control group, one with dummy exposure (sham), a group exposed to 50μT CM and another exposed to 500μT, which were exposed during a spermatogenic cycle (35 days). The weight of the testicles and epididymis ...
3
artículo
Publicado 2016
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The objective of this article was to investigate the effects of chronic exposure to magnetic fields (MC) of existing environmental levels in the city of Lima on the reproductive health of male mice. Firstly, the information on the levels of the magnetic fields of electric power lines measured in Peru and other countries as well as the exposure limits of the international commission for protection against electromagnetic fields (ICNIRP) were reviewed to define the levels to which it would be exposed to biological material. The biological sample was 32 10-week-old male mice (Mus musculus) of the Balb C strain, with which four experimental groups of 8 mice each were formed, including a control group, one with dummy exposure (sham), a group exposed to 50μT CM and another exposed to 500μT, which were exposed during a spermatogenic cycle (35 days). The weight of the testicles and epididymis ...
4
artículo
Objectives. To evaluate the effect of Myrciaria dubia (camu camu) flour on liver tissue induced to acetaminophen toxicity in mice. Methods. Experimental design. A suspension of camu camu flour (HCC) with 1.6% starch was prepared. 40 male mice of the BALB/c strain were used, with an average weight of 30.8 g and two months of age, which were divided into five groups, receiving the following treatment, orogastric route, for a period of 10 days, groups I and II: 1.6% starch 10 mL / kg; group III: HCC 200 mg / kg, group IV: HCC 500 mg / kg and group V: HCC 800 mg / kg. On the 6th day of treatment, acetaminophen (300 mg / kg) was administered to groups II-V until the 10th day. After the intervention, the animals were fasted for 12 hours, to then be sacrificed after anesthesia with sodium pentobarbital. The liver was removed, the greater lobe was identified and sectioned for biochemical and his...
5
artículo
Publicado 2012
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Introduction: Piper aduncum also known as matico is credited with antihypertensive, anti-inflammatory, healing effects. Objectives: To determine the antihypertensive activity of Piper aduncum ‘matico’ extract on L-NAME-induced hypertension in mice. Design: Experimental. Setting: Faculty of Medicine, and Faculty of Pharmacy and Biochemistry, National University of San Marcos, Lima, Peru. Biological material: Piper aduncum ethanolic extract leaves and mice. Interventions: Six groups of six Muss musculus mice each were used, one without hypertension (negative control) and four with L-NAME-induced hypertension: one positive control and three groups for 50, 150 and 300 mg/kg doses, respectively. Treatment was given orally once daily for 25 days. Measurements of systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) were performed twice weekly (Tuesd...
6
artículo
Publicado 2011
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The leaves of soursop (Annona muricata L.) are traditionally used to treat acute diarrhea; the matter, has not found enough information to validate its property antidiarrheal, so was proposed to assess experimentally the action and acute toxicity. For that, 11 groups were formed randomly, 6 male mice Balb-C 56 each. Group one served as control (1 mL saline), the experimental groups 2, 3, 4, 5, 6 and 7 received methanol extract of Annona muricata L. in doses: 10, 25, 50, 75, 100 and 200 mg/kg body weight, respectively; the group eight received loperamide 1 mg/kg and the group nine castor oil 10 mL/kg. Activated carbon was used as a marker of intestinal transit by model in vivo in mice. The lethal dose 50 for the biological sample was 229 mg/kg, with a confidence interval of 95% (244,3 upper and lower 220,9). At doses of 25 mg/kg of Annona muricata L., a reduction of intestinal transit of ...
7
artículo
Publicado 2011
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The leaves of soursop (Annona muricata L.) are traditionally used to treat acute diarrhea; the matter, has not found enough information to validate its property antidiarrheal, so was proposed to assess experimentally the action and acute toxicity. For that, 11 groups were formed randomly, 6 male mice Balb-C 56 each. Group one served as control (1 mL saline), the experimental groups 2, 3, 4, 5, 6 and 7 received methanol extract of Annona muricata L. in doses: 10, 25, 50, 75, 100 and 200 mg/kg body weight, respectively; the group eight received loperamide 1 mg/kg and the group nine castor oil 10 mL/kg. Activated carbon was used as a marker of intestinal transit by model in vivo in mice. The lethal dose 50 for the biological sample was 229 mg/kg, with a confidence interval of 95% (244,3 upper and lower 220,9). At doses of 25 mg/kg of Annona muricata L., a reduction of intestinal transit of ...
8
artículo
Publicado 2025
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Objective: This study evaluated the sedative effect of the hydroalcoholic extracts from the leaves of Valeriana pinnatifida Ruiz & Pav (valerian) and Passiflora edulis Sims (passionflower) in albino mice (Holtzman). Material and Methods: 30 Holtzman albino mice were used, acquired from the National Agrarian University La Molina (UNALM). The mice were selected and assigned to groups using simple random probability sampling, forming 6 groups of 5 specimens each. Each group received a different treatment with the hydroalcoholic extracts: Valeriana pinnatifida at doses of 20 mg/kg and 50 mg/kg, and Passiflora edulis at doses of 50 mg/kg and 100 mg/kg. To induce anxiety, the elevated plus maze test was used. Subsequently, ANOVA and Tukey tests were applied to determine the concentration and group with the highest sedative activity. Results: The results indicate that the hydroalcoholic ext...
9
10
artículo
Publicado 2022
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Isaño and cola de caballo are used in Bolivia for their traditional use as a diuretic, but there are nopharmacological studies that confirm this effect. Objective: to determine the diuretic effect of theaqueous extract of isaño and cola de caballo. Methodology: male mice were used, which were dividedinto four groups, a positive and negative control and two dose groups (D1 and D2) of the extract. Bothdried plants were fractionated for the preparation of the aqueous extract, with which the preliminaryphytochemical screening was carried out, and the technique described by Lipschitz was carried out todetermine the diuretic effect. Results: The phytochemical analysis revealed the presence of flavonoidsfor the aqueous extract of cola de caballo. And the aqueous extract of Isaño showed the presenceof tannins, anthocyanins and flavonoids. The highest volume of urine collected was for the posi...
11
artículo
Publicado 2017
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Objective of this experimental study was to determine the antihypertensive and toxic activities of methanolic extract from Calceolaria myriophylla (zapatilla). Male albino mice Mus musculus BALB/c of two months, 25±5 g weigth, were used for induction of hypertension with N-nitro-L-arginine methyl ester (L-NAME) administered at doses of 130 mg/kg/day, orally for seven days, measuring baseline and post induction blood pressure. The mice were divided into six groups of ten animals: negative control (distilled water), positive control (L-NAME), experimental groups at doses of 200, 400 and 600 mg/kg of methanolic extract, and enalapril group to doses 75 mg/kg. The treatment was administered for 30 days continuous and blood pressure was measured every five days. The study of chronic toxicity was determined to repeated doses for 60 days in normotensive rats, divided into three groups of six an...
12
tesis de maestría
Publicado 2022
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Memory is an adaptive tool for survival. It is critical to remember events accurately in order to learn and interact with our surroundings. In that regard, noradrenaline and corticosterone stress hormones have been proven to improve memory but also disrupt it depending on the instant that these hormones levels rise in the brain (during information encoding, consolidating or retrieval). A less investigated aspect would be how these two stress hormones influence memory accuracy. Over time, episodic-like memories are transformed into more semantic ones, which become less dependent on the hippocampus and more dependent on cortical regions like the medial pre-frontal cortex (mPFC). The purpose of this study was to investigate the effect of yohimbine (α2-noradrenergic receptor antagonist that increases noradrenaline levels) and corticosterone in memory accuracy in a low-arousing episodic-like...
13
artículo
Publicado 2023
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Objective: This study aimed to determine the antinociceptive effect of the hydroalcoholic extract of Lepechinia meyenii (Walp.) Epling "pacha sage" leaves in acetic acid-induced pain in mice. Material and methods: The plant material was collected in the Molinos district, Jauja Province (Junín). The hydroalcoholic extract was obtained using the maceration process, followed by phytochemical screening and solubility tests. The analgesic effect was evaluated using the acetic acid-induced abdominal writhing method, with 30 BALB/c albino mice divided into 5 treatment groups: Negative Control (physiological saline), Positive Control (tramadol 40mg/kg), and three experimental groups (Hydroalcoholic extract at doses of 200mg/kg, 400mg/kg, and 600mg/kg). Results: The analgesia percentages for the extract at doses of 200mg/kg were 2.9%, 6.2% at 400mg/kg, and 49.4% at 600mg/kg, compared to 95% for ...
14
tesis de maestría
Publicado 2022
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Memory is an adaptive tool for survival. It is critical to remember events accurately in order to learn and interact with our surroundings. In that regard, noradrenaline and corticosterone stress hormones have been proven to improve memory but also disrupt it depending on the instant that these hormones levels rise in the brain (during information encoding, consolidating or retrieval). A less investigated aspect would be how these two stress hormones influence memory accuracy. Over time, episodic-like memories are transformed into more semantic ones, which become less dependent on the hippocampus and more dependent on cortical regions like the medial pre-frontal cortex (mPFC). The purpose of this study was to investigate the effect of yohimbine (α2-noradrenergic receptor antagonist that increases noradrenaline levels) and corticosterone in memory accuracy in a low-arousing episodic-like...
15
artículo
Publicado 2015
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Se realizaron pruebas de bioseguridad para evaluar los posibles efectos patogénicos del aislamiento autóctono LF14 de Beauveria bassiana en ratones albinos NMRI; el cual posee una elevada virulencia hacia Rhodnius prolixus y Triatoma maculata (Triatominae), vectores de enfermedad de Chagas en Venezuela. Se administró 1x109 conidias/ml del hongo mediante gotas nasales. Se realizaron observaciones clínicas y de comportamiento, así como de peso corporal en forma diaria y por 14 días. Asimismo, se estimó el aclaramiento fúngico mediante examen directo y cultivo de muestras intranasales, y de infectividad con la toma de muestras de tejidos de varios órganos, incluyendo un estudio histopatológico a los 3, 7 y 14 días después de la inoculación. No ocurrieron muertes ni alteraciones clínico-patológicas discernibles, siendo el tipo de comportamiento activo-normal en el 100% de los ...
16
tesis de grado
Publicado 2023
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Determina la contribución de la puesta en valor del folclor al turismo MICE en la ciudad de Lima en Perú. La presente investigación es de enfoque cuantitativo y transversal, con diseño no experimental. Asimismo, se analiza las asociaciones folclóricas de la ciudad de Lima y las principales instituciones involucradas en la organización de eventos folclóricos en la ciudad de Lima. Como instrumentos de investigación, se utiliza encuestas para ambas poblaciones. De acuerdo al diagnóstico realizado, se confirmó que la puesta en valor del folclor contribuye en forma significativa al turismo MICE en la ciudad de Lima, 2022. El turismo MICE visibilizar culturas como lo es folclor, por ello se afirma la posibilidad de posicionar el segmento MICE en la ciudad de Lima, mediante la puesta en escena de eventos culturales de tipo folclórico. De esta manera, se concluye que no solo se revalo...
17
artículo
Publicado 2003
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La linfadenitis granulomatosa es una enfermedad de significancia económica en alpacas, la cual es causada por Corynebacterium pseudotuberculosis, una bacteria gram positiva cuyo principal factor de virulencia es una exotoxina (fosfolipasa D). El objetivo del presente trabajo fue probar la eficacia de una vacuna elaborada a partir de precipitado proteico de C. pseudotuberculosis conteniendo la exotoxina, en un grupo de 20 ratones (grupo vacunado), quienes recibieron el inóculo con C.pseudotuberculosis, frente a otro grupo de 20 ratones (grupo control), quienes recibieron placebo y el inóculo. La inmunización del grupo vacunado con 16 g del precipitado proteico de C. pseudotuberculosis indujo protección después de la inoculación intraperitoneal con 104 UFC de C. pseudotuberculosis. La vacuna disminuyó los efectos tóxicos del C. pseudotuberculosis, lo cual se observó con la dismin...
18
artículo
Publicado 2003
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The granulomatous lymphadenitis is an economically important infectious disease in alpacas. This disease is caused by Corynebacterium pseudotuberculosis, which is a gram positive bacterium that has an exotoxin (Phospholipase D) as its main virulence factor. The objective of this study was to test the efficacy of a vaccine in a group of mice (20 vaccinated and 20 control). The vaccine was prepared with protein extracts from C. pseudotuberculosis isolated from an alpaca, containing the exotoxin, and used for the immunization of mice which received 16 g of protein extract. This confered protection after challenging intraperitoneally with 104 UFC of C. pseudotuberculosis. The vaccine ameliorated the toxic effects of C. pseudotuberculosis, which was evidenced by the decrease in number and size of abscesses in the vaccinated group (40% affected), in contrast with the severe and systemic damage...
19
tesis de grado
Publicado 2023
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El presente trabajo de investigación tuvo como objetivo: Determinar las características de la calidad del servicio y atención al cliente en la bodega Miceli del Caserío San Vicente de Piedra Rodada - Sullana Año 2020. La investigación tuvo un diseño no experimental_ transversal_ descriptiva, de tipo cuantitativa y nivel descriptivo. Para el recojo de información se acudió a la bodega Miceli, se obtuvo una población muestral de 68 clientes, aplicando como instrumento un cuestionario de 20 preguntas a los representantes, a través de la técnica de encuesta. Obteniendo los siguientes resultados principales: Con respecto a la calidad del servicio; el 86.76% señalaron que siempre existe un respeto mutuo entre el personal que labora con los clientes, el 85.29% afirmaron que siempre los productos exhibidos en la bodega están ordenados. Con respecto a la atención al cliente; el 80....
20
artículo
Publicado 2017
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El presente estudio experimental tuvo como objetivo determinar las actividades antihipertensiva y tóxica del extracto metanólico de Calceolaria myriophylla (zapatilla). Se utilizaron ratones albinos machos Mus musculus BALB/c, de dos meses con peso de 25±5 gramos para la inducción de hipertensión arterial con la administración de N-nitro-L-arginina metíl eter (L-NAME) a dosis de 130 mg/kg/día, vía oral durante siete días, midiéndose la presión arterial basal, y post inducción. Los ratones fueron divididos en seis grupos de diez animales: grupo control negativo (agua destilada), control positivo (L-NAME), grupos experimentales a dosis de 200, 400 y 600 mg/kg del extracto metanólico, y enalapril a 75 mg/kg. Se administró el tratamiento durante 30 días continuos, midiendo la presión arterial cada cinco días. El estudio de toxicidad crónica se determinó a dosis repetidas ...
