Universidad Nacional Agraria La Molina. Facultad de Agronomía. Departamento Académico de Fitotecnia

Introduction: Piper aduncum also known as matico is credited with antihypertensive, anti-inflammatory, healing effects. Objectives: To determine the antihypertensive activity of Piper aduncum ‘matico’ extract on L-NAME-induced hypertension in mice. Design: Experimental. Setting: Faculty of Medicine, and Faculty of Pharmacy and Biochemistry, National University of San Marcos, Lima, Peru. Biological material: Piper aduncum ethanolic extract leaves and mice. Interventions: Six groups of six Muss musculus mice each were used, one without hypertension (negative control) and four with L-NAME-induced hypertension: one positive control and three groups for 50, 150 and 300 mg/kg doses, respectively. Treatment was given orally once daily for 25 days. Measurements of systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) were performed twice weekly (Tuesd...

Objectives: To determine the protective effect of Piper aduncum (matico) leaves ethanol extract and its phytomedicine in capsules in liver cirrhosis induced in rats. Design: Experimental. Location: Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru. Biological material: Leaves of Piper aduncum, and Rattus norvegicus, Holtzman strain. Interventions: The leaves were collected in La Merced district, Pasco department. The phytomedicine capsules were prepared from the plant ethanol extract. Cirrhosis was induced with phenobarbital 0.5 mg/mL diluted in drinking water during 15 days, then carbon tetrachloride 0.2mL/kg 1:1 in olive oil orally during 7 days. Blood samples were drawn in order to determine liver profile and malondialdehyde; the animals were sacrificed, extracting the liver for pathology study. Data were evaluated by multivariate techniques with p <0.05. Ma...

Introduction: Piper aduncum (matìco) is a medicinal plant used for gastrointestinal and genitourinary disorders. Objectives: To determine the in vitro antitumoral effect of Piper aduncum (matico) essential oil on seven human tumoral cell lines and its oral toxicity in mice. Design: Experimental. Setting: Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru. Biologic material: Human tumoral cell lines HT-29, H-460, MCF-7, M-14, ME-180, DU-145, K-562; and 3T3 fibroblasts and male 40 days post weaning Balb C/53 mice. Interventions: The cell lines HT-29, H-460, MCF-7, M-14, ME-180, DU-145, K-562, and 3T3 were exposed to four different concentrations of Piper aduncum essential oil, and to different 5-fluorouracil concentrations used as a positive control. Cell lines growth inhibition (IC50) was determined using linear regression analysis and DL50 by the number of deaths ...