This present study of experimental design had as aim determines the anti-inflammatory effect of Oenothera rosea (Yawar socco) in rats which were induced acute and chronic inflammation. The whole plant was dried at 38 °C in an oven with circulating air, ground and macerated with a mix ethanol/water (70:30)1. It was used winter experimental model to evaluate the acute state (subplantar edema) induced with carrageenan and the model of xylene-induced edema ear. To determine the chronic inflammatory activity was used the model of carrageenan-induced granuloma using a modification of the technique described by Sedwick and Lees. It was used 132 albino rats of 300 g randomly divided in groups of eight each, one whereas a control with saline solution 5 mL/kg, one with the agent that induces inflammation (AI), AI groups and extract in 3 doses also with dexamethasone and ibuprofen, being 56 rats f...

This present study of experimental design had as aim determines the anti-inflammatory effect of Oenothera rosea (Yawar socco) in rats which were induced acute and chronic inflammation. The whole plant was dried at 38 °C in an oven with circulating air, ground and macerated with a mix ethanol/water (70:30)1. It was used winter experimental model to evaluate the acute state (subplantar edema) induced with carrageenan and the model of xylene-induced edema ear. To determine the chronic inflammatory activity was used the model of carrageenan-induced granuloma using a modification of the technique described by Sedwick and Lees. It was used 132 albino rats of 300 g randomly divided in groups of eight each, one whereas a control with saline solution 5 mL/kg, one with the agent that induces inflammation (AI), AI groups and extract in 3 doses also with dexamethasone and ibuprofen, being 56 rats f...

The leaves of soursop (Annona muricata L.) are traditionally used to treat acute diarrhea; the matter, has not found enough information to validate its property antidiarrheal, so was proposed to assess experimentally the action and acute toxicity. For that, 11 groups were formed randomly, 6 male mice Balb-C 56 each. Group one served as control (1 mL saline), the experimental groups 2, 3, 4, 5, 6 and 7 received methanol extract of Annona muricata L. in doses: 10, 25, 50, 75, 100 and 200 mg/kg body weight, respectively; the group eight received loperamide 1 mg/kg and the group nine castor oil 10 mL/kg. Activated carbon was used as a marker of intestinal transit by model in vivo in mice. The lethal dose 50 for the biological sample was 229 mg/kg, with a confidence interval of 95% (244,3 upper and lower 220,9). At doses of 25 mg/kg of Annona muricata L., a reduction of intestinal transit of ...

The leaves of soursop (Annona muricata L.) are traditionally used to treat acute diarrhea; the matter, has not found enough information to validate its property antidiarrheal, so was proposed to assess experimentally the action and acute toxicity. For that, 11 groups were formed randomly, 6 male mice Balb-C 56 each. Group one served as control (1 mL saline), the experimental groups 2, 3, 4, 5, 6 and 7 received methanol extract of Annona muricata L. in doses: 10, 25, 50, 75, 100 and 200 mg/kg body weight, respectively; the group eight received loperamide 1 mg/kg and the group nine castor oil 10 mL/kg. Activated carbon was used as a marker of intestinal transit by model in vivo in mice. The lethal dose 50 for the biological sample was 229 mg/kg, with a confidence interval of 95% (244,3 upper and lower 220,9). At doses of 25 mg/kg of Annona muricata L., a reduction of intestinal transit of ...