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1
artículo
Publicado 2023
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Objective: To assess the degree of hemoglobin correlation as a possible predictor of hematocrit and red blood cell count according to age and sex in a population of the district of Villa El Salvador, Lima, Peru. Materials and methods: An observational, analytical, correlational and prospective study carried out with 550 menand 700 women of all ages who attended monthly preventive-promotional health campaigns, as well as routine medicalconsultations, from January 2021 to June 2022. Collected data consisted of hematocrit, red blood cells and hemoglobincounts. The Spearman’s correlation coefficient was used. Results: There was a higher prevalence of anemia in the group of women older than 11 years (35.10 %), while hemoglobin levels in most children younger than 11 years were mainly normal. High and positive correlations between hemoglobin and hematocrit close to one were found in all age ...
2
artículo
Publicado 2023
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Introduction: Stage III non-small-cell lung cancer (NSCLC) management is challenging given the heterogeneous nature of the disease. The LATAM subset of the real-world, global KINDLE study reported the treatment patterns and clinical outcomes for LATAM from the pre-immuno-oncology era. Methods: The study was conducted in seven countries (Argentina, Chile, Colombia, Dominican Republic, Mexico, Peru and Uruguay) in stage III NSCLC (American Joint Committee on Cancer, 7th edition) diagnosed between January 2013 and December 2017. Retrospective data from patients' medical records (index date to the end of follow-up) were collected. Summary statistics, Kaplan–Meier survival estimates and a two-sided 95% confidence interval (CI) were provided. Cox proportional hazard model was used for univariate and multi-variate analyses. Results: A total of 231 patients was enrolled, the median age was 65....
3
artículo
Publicado 2018
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First, we would like to acknowledge and thank all the patients for willingly participating in medical research and making advancement in the care of patients with sickle cell disease possible. VAS is supported by an American Society of Hematology Scholar Award, and National Heart, Lung and Blood Institute, 1K08DK110448-01. JCBA has been sponsored by Cienciactiva, an initiative of the Peruvian National Council of Science, Technology and Technological Innovation (CONCYTEC); grant contract number 231-2015-FONDECYT. PEG would also like to thank Dr. Alex George for access to clinical data and help with the study preparation and conceptualization.
4
artículo
Publicado 2019
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VM was a recipient of an FPI fellowship and from Ciberned. This work was funded by grant SAF2013-40710-R and by Ciberned and JZ waspartially supported by Cienciactiva, an initiative of the the National Council of Science, Technology and Technological Innovation-CONCYTEC, Perú.
5
artículo
Publicado 2013
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The purpose of this study was to determine the survival and prognostic factors of patients with diffuse large B-cell lymphoma (DLBCL) of the oral cavity and maxillofacial region. Retrospectively, the clinical records of patients with a primary diagnosis of DLBCL of the oral cavity and maxillofacial region treated at the A.C. Camargo Hospital for Cancer, São Paulo, Brazil, between January 1980 and December 2005 were evaluated to determine (A) overall survival (OS) at 2 and 5 years and the individual survival percentage for each possible prognostic factor by means of the actuarial technique (also known as mortality tables), and the Kaplan Meier product limit method (which provided the survival value curves for each possible prognostic factor); (B) prognostic factors subject to univariate evaluation with the log-rank test (also known as Mantel-Cox), and multivariate analysis with Cox's reg...
6
artículo
Publicado 2019
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Undifferentiated carcinoma with undifferentiated osteoclast-like cells (UC-OGC) in the head of the pancreas is extremely rare. The clinicalpathological, imaging and topographic appearance characteristics are not wellclassified. This case report describes a patient with UC-OGC of the Pancreas Head. Our patient, an adult over 75 years of age, had a considerable illness time, without relevant symptoms until the advanced stages of the tumor, debuting with shallow gastric discomfort, then weight loss. In the diagnostic tests they found the presence of a tumor that compromised the stomach, duodenum and pancreas. The definitive diagnosis was given by the pathological study. There are not enough clinical data available for a treatment that guarantees a higher survival rate in patients, however, pancreatoduodenectomy is currently the alternative that offers the best results, on the other hand, th...
7
artículo
Publicado 2020
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Objective: The aim of this study was to determine the association between Red Blood cell Distribution width and Proliferative Diabetic Retinopathy in patients with type 2 diabetes. Methods: We conducted a hospital-based case-control study. Adult patients (≥ 18 years old) with the diagnosis of Diabetic Retinopathy who underwent medical check-ups at the ophthalmology department where enrolled in our study. We selected a total sample size of 262 patients, of which 131 cases had Proliferative Diabetic Retinopathy and 131 controls had Non Proliferative Diabetic Retinopathy. Data about age, gender, body mass index, history of hypertension, diabetic nephropathy, Congestive heart failure, Hemoglobin and HbA1c were registered for individuals who met inclusion criteria. Odds ratio model was used to test the relationship between Red Blood Cell Distribution Width and Proliferative Diabetic Re...
8
artículo
Publicado 2022
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Introduction: The COVID-19 pandemic has caused a global health crisis. Vaccines against this disease have demonstrated variable efficacy and safety, although effectiveness has not been evaluated. In February 2021, the Ministry of Health of Peru approved the emergency use of the inactivated SARS-CoV-2 (Vero Cell) vaccine and initiated vaccination with health personnel at the national level. The objective of the study is to determine the effectiveness of this vaccine to reduce infections, hospitalizations, and deaths due to COVID-19. Methodology: We performed a retrospective cohort study in the period from 23 February to 26 June 2021; data were obtained from the Ministry of Health (including demographic, epidemiologic, clinical, hospital, laboratory results, deaths, and both date and quantity of vaccine doses delivered). The exposed cohort were those who received one or two vaccine doses a...
9
artículo
Publicado 2021
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This study was funded by the French National Alliance for Life Sciences and Health (ENV201408); LC was a recipient of a doctoral fellowship from French National Research Institute for Sustainable Development (IRD) (EMHE-ARTS-2016-878573B); JPC was a recipient of a doctoral fellowship from the Peruvian National Council for Science and Technology (212-2015-FONDECYT); SB has received funding from the European Union’s Horizon 2020 Framework program under the Marie Sk?odowska-Curie Actions 823935 and from the Alliance pour les Sciences de la Vie et de la Santé (AVIESAN), ITMO Cancer ENV201408, and LC, ER, and SCZ have received funding from the World Bank Group and FONDECYT-CONCYTEC 016-2018-FONDECYT/BM. The authors are grateful to Karina Cancino, Danny Cordova (INEN Cancer Research Biobank), Patricia Leroyer (NUMECAN), Alain Fautrel, Marine Seffals, Gevorg Ghukasyan (H2P2 platform). They a...
10
artículo
Publicado 2025
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Objective: To compare the frequency of oral squamous cell carcinoma in an oral and maxillofacial pathology laboratory at a teaching dental center of a Peruvian university across three decades (1991 -2020). Materials and methods: A cross-sectional, observational, descriptive, retrospective study was conducted. Age group, sex, clinical manifestations, anatomical location, and decade were analyzed. Collected data were coded to preserve patient anonymity and recorded on standardized data collection form. Statistical analysis was performed using STATA 16.0 software, applying the chi-square test and Fisher's exact test, with a 95% confidence level and p < 0.05. Results: A total of 735 records were included, the mean age was 53 years. The age group with the highest frequency was 70-79 years (n = 177). The main clinical manifestations were tumors (50.75 %) and ulcers (31.68 %). The most frequ...
11
artículo
Publicado 2024
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Introducción. El trasplante autólogo de células progenitoras hematopoyéticas es una terapia eficaz en neoplasias malignas hematológicas. El número de células que CD34+ en sangre periférica es el mejor predictor del rendimiento de recolección de células progenitoras hematopoyéticas. Objetivo. Determinar el número de células CD34+ en sangre periférica asociado al éxito de recolección de progenitores hematopoyéticos por aféresis en trasplante autólogo. Métodos. Se evaluó retrospectivamente los datos de 236 procedimientos de aféresis de células progenitoras hematopoyéticas para el trasplante autólogo en el Hospital Edgardo Rebagliati Martins (Lima, Perú) de julio del 2020 a julio del 2023. Se utilizó la curva ROC (características operativas del receptor) para determinar el número de células CD34+ en sangre periférica necesario para lograr una recolección por a...
12
artículo
Publicado 2023
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PURPOSEMultiple myeloma (MM) is a highly heterogeneous, incurable disease most frequently diagnosed in the elderly. Therefore, data on clinical characteristics and outcomes in the very young population are scarce.PATIENTS AND METHODSWe analyzed clinical characteristics, response to treatment, and survival in 103 patients with newly diagnosed MM age 40 years or younger compared with 256 patients age 41-50 years and 957 patients age 51 years or older.RESULTSThere were no statistical differences in sex, isotype, International Scoring System, renal involvement, hypercalcemia, anemia, dialysis, bony lesions, extramedullary disease, and lactate dehydrogenase (LDH). The most used regimen in young patients was cyclophosphamide, bortezomib, dexamethasone, followed by cyclophosphamide, thalidomide, dexamethasone and bortezomib, thalidomide, dexamethasone. Of the patients age 40 years or younger, o...
13
artículo
Publicado 2019
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Undifferentiated carcinoma with undifferentiated osteoclast-like cells (UC-OGC) in the head of the pancreas is extremely rare. The clinicalpathological, imaging and topographic appearance characteristics are not wellclassified. This case report describes a patient with UC-OGC of the Pancreas Head. Our patient, an adult over 75 years of age, had a considerable illness time, without relevant symptoms until the advanced stages of the tumor, debuting with shallow gastric discomfort, then weight loss. In the diagnostic tests they found the presence of a tumor that compromised the stomach, duodenum and pancreas. The definitive diagnosis was given by the pathological study. There are not enough clinical data available for a treatment that guarantees a higher survival rate in patients, however, pancreatoduodenectomy is currently the alternative that offers the best results, on the other hand, th...
14
artículo
Publicado 2020
Enlace
Enlace
Objective: The aim of this study was to determine the association between Red Blood cell Distribution width and Proliferative Diabetic Retinopathy in patients with type 2 diabetes. Methods: We conducted a hospital-based case-control study. Adult patients (≥ 18 years old) with the diagnosis of Diabetic Retinopathy who underwent medical check-ups at the ophthalmology department where enrolled in our study. We selected a total sample size of 262 patients, of which 131 cases had Proliferative Diabetic Retinopathy and 131 controls had Non Proliferative Diabetic Retinopathy. Data about age, gender, body mass index, history of hypertension, diabetic nephropathy, Congestive heart failure, Hemoglobin and HbA1c were registered for individuals who met inclusion criteria. Odds ratio model was used to test the relationship between Red Blood Cell Distribution Width and Proliferative Diabetic Re...
15
tesis de grado
Publicado 2021
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Background: Text messaging (SMS) interventions to improve HIV retention in care have shown mixed results, probably due to the diversity of features of their design and implementation. Methods: Using routinely collected data of the largest HIV program in Lima, we retrospectively evaluated the efficacy of an adapted single-arm, one-way SMS pilot intervention, intended to improve compliance with medical and ART pick-up appointments, by use of (i) SMS reminders before scheduled visits, (ii) a motivational SMS after scheduled visit, and (iii) phone calls after missed visits delivered for up to 9 months. The SMS group included people living with HIV (PLWH) ages 18-29 starting or restarting antiretroviral therapy (ART). For the control group, we non-randomly selected PLWH up to 35 years-old who were enrolled in the same HIV program within overlapping or closest dates to those of the SMS group (...
16
artículo
Publicado 2024
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Introducción. El trasplante autólogo de células progenitoras hematopoyéticas es una terapia eficaz en neoplasias malignas hematológicas. El número de células que CD34+ en sangre periférica es el mejor predictor del rendimiento de recolección de células progenitoras hematopoyéticas. Objetivo. Determinar el número de células CD34+ en sangre periférica asociado al éxito de recolección de progenitores hematopoyéticos por aféresis en trasplante autólogo. Métodos. Se evaluó retrospectivamente los datos de 236 procedimientos de aféresis de células progenitoras hematopoyéticas para el trasplante autólogo en el Hospital Edgardo Rebagliati Martins (Lima, Perú) de julio del 2020 a julio del 2023. Se utilizó la curva ROC (características operativas del receptor) para determinar el número de células CD34+ en sangre periférica necesario para lograr una recolección por a...
17
tesis de grado
Publicado 2023
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El despliegue de redes móviles 5G basados en el estándar Non-Standalone (NSA) utilizando el Multiple-Input Multiple-Output Massive (MIMO), se ha convertido en una veloz competencia a nivel mundial y a la misma ves una necesidad, países de primer mundo como Estados Unidos y China han sido los pioneros en desarrollar esta tecnología. A nivel de la región diversos países como Chile, Brasil, Uruguay, Colombia y Argentina se encuentran adaptando sus redes tradicionales a la nueva era tecnológica de 5G. El Perú no ha sido ajeno a ello, a inicios del año 2021 el Ministerio de Transporte y Comunicaciones (MTC) autorizó el uso de espectro electromagnético a dos operadores móviles del estado peruano para que a través de ello puedan brindar servicios 5G. El tráfico de datos móviles ha aumentado a un ritmo exponencial, así como como el número de usuarios de teléfonos inteligentes, ...
18
tesis de grado
Publicado 2025
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La enfermedad de células falciformes es un trastorno hereditario causado por la presencia de hemoglobina S, con alta mortalidad infantil y complicaciones crónicas. En países en desarrollo, su impacto podría reducirse con diagnóstico temprano y tratamiento oportuno. Este estudio evalúa un método en papel, simple, económico y sin necesidad de equipos complejos, para detectar anemia falciforme en pacientes pediátricos de un hospital en Lima. El objetivo es determinar la utilidad, sensibilidad y especificidad del método de papel frente a la electroforesis de hemoglobina, así como analizar la relación con variables demográficas como edad, sexo y raza. El diseño del estudio es observacional, prospectivo y transversal, con enfoque cuantitativo. Se analizarán 291 muestras seleccionadas de forma no probabilística entre 1181 pacientes atendidos entre junio y diciembre de 2025. Los ...
19
tesis de grado
Publicado 2025
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La investigación fue de tipo básica, no experimental, transversal y un enfoque cuantitativo. La muestra estuvo conformada por 128 registros de pacientes. La recolección de datos se realizó a través de la aplicación de ficha técnica de recolección de datos con todos los parámetros requeridos. Para el análisis descriptivo inferencial de los datos obtenidos se emplearon los programas Microsoft Excel y el programa STATA versión 17. Por otro lado, para determinar la correlación entre ambas variables, se aplicará la prueba chi Cuadrado (Pearson, Exacta de Fisher o Yates) de acuerdo con la evaluación del supuesto de frecuencias esperadas. La relación entre la carga viral y las alteraciones hematológicas serán evaluadas en un modelo multivariado de regresión de Poisson, con el cálculo de la razón de prevalencia cruda y ajustada por edad, sexo y tiempo de infección. Se consid...
20
tesis de grado
Publicado 2022
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Establecer un régimen alimenticio concernientes con insuficiencia de glóbulos rojos en infantes de seis meses a 2 años de edad del puesto de sanidad la Quebrada, San Luis, cañete – 2022. Tipo de indagación elemental, prospectiva, observacional y transversal. Esta localidad incluye usuarios del establecimiento del centro poblado la quebrada, ubicados en San Luis Cañete, en junio y agosto de 2022; este modelo es de 100 clientes. La herramienta usada fue un sondeo y 1 cuestionario, el cual registrará datos sobre la dieta del niño, como el consumo de leche materna, variedad de comestibles.Estos elementos de régimen alimenticio concernientes con insuficiencia de glóbulos rojos, consumo con comestibles altos en micronutrientes, alimentos fuentes de hierro y Retinol, con acompañamiento alimenticio con inhibidores de la absorción de hierro, esta correspondencia es clase contradicto...
