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artículo

Epidemiology and Risk Factors for the Development of Infectious Complications in Newly Diagnosed Multiple Myeloma: A Multicenter Prospective Cohort Study in Latin America

Publicado por
Bove, V, Riva, E, Vásquez-Chavez, J, Peña, C, Seehaus, C, Samanez, C, Bustos, J, Hernández, M, Fernández, J, Ríos, O, Rodríguez, Y, Figueredo, I, Fantl, D, Malpica, L

Publicado 2022

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PURPOSE: Infections are a significant cause of morbidity and mortality in patients with multiple myeloma (MM). In Latin America, data on infectious complications in this patient population are lacking. METHODS: We conducted a prospective cohort study of patients with newly diagnosed MM (NDMM) in seven Latin American countries between June 2019 and May 2020. Patients with active disease, on active therapy, and with a follow-up of 6 months from the time of diagnosis were included. Our primary end point was the number of infectious events that required hospitalization for ≥ 24 hours. RESULTS: Of 248 patients with NDMM, 89 (35.9%) had infectious complications (113 infectious events), the majority (67.3%) within the first 3 months from diagnosis. The most common sites of infection were respiratory (38%) and urinary tract (31%). The microbial agent was identified in 57.5% of patients with gr...

artículo

Patients Age 40 Years and Younger with Multiple Myeloma Have the Same Prognosis as Older Patients: An Analysis of Real-World Patients' Evidence from Latin America

Publicado por
Martinez-Cordero, H, Peña, C, Schutz, NP, Bove, V, Villano, F, Beltran, C, Donoso, J, Lopez-Vidal, H, Roa-Salinas, MA, Soto, P, Ochoa, P, Duarte, P, Remaggi, G, Corzo, A, Shanley, C, Lopresti, S, Orlando, S, Verri, V, Quiroga, LD, Fantl, D, Ramirez, J, Ospina-Idarraga, A, Idrobo, H, Quintero, G, Gomez, R, Cantu-Martinez, O, Gomez-Almaguer, D, Ruiz-Arguelles, GJ, Galvez-Cardenas, KM, Salazar, LA, Novoa-Caicedo, I, Fuentes-Lacouture, MC, Spirko, P, Arbelaez, MI, Pereira, M, Valdes, J, Vasquez, J, Von-Glasenapp, A, Riva, E

Publicado 2023

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PURPOSEMultiple myeloma (MM) is a highly heterogeneous, incurable disease most frequently diagnosed in the elderly. Therefore, data on clinical characteristics and outcomes in the very young population are scarce.PATIENTS AND METHODSWe analyzed clinical characteristics, response to treatment, and survival in 103 patients with newly diagnosed MM age 40 years or younger compared with 256 patients age 41-50 years and 957 patients age 51 years or older.RESULTSThere were no statistical differences in sex, isotype, International Scoring System, renal involvement, hypercalcemia, anemia, dialysis, bony lesions, extramedullary disease, and lactate dehydrogenase (LDH). The most used regimen in young patients was cyclophosphamide, bortezomib, dexamethasone, followed by cyclophosphamide, thalidomide, dexamethasone and bortezomib, thalidomide, dexamethasone. Of the patients age 40 years or younger, o...