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The Latin-American Experience in POEMS Syndrome: A Study of the GELAMM (Grupo de Estudio Latinoamericano de Mieloma Múltiple)

Publicado por
Gallardo-Pérez, MM, Negrete-Rodríguez, P, Gertz, MA, Peña, C, Riva, E, Gilli, V, Rodríguez, G, Samánez, C, Ferreira, J, Portiño, S, Montaña, J, León, P, Gutiérrez, Y, Del-Castanhel, C, Seehaus, C, Funes, ME, Meneces-Bustillo, R, Duarte, P, Shanley, C, Elvira, G, Ochoa, P, López-Vidal, H, Martinez-Cordero, H, Vasquez, J, Von-Glasenapp, A, Donoso, J, Viñuela, JL, Ruiz-Delgado, GJ, Ruiz-Argüelles, GJ

Publicado 2024

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Introduction: POEMS syndrome is a rare paraneoplastic syndrome caused by an underlying plasma cell disorder. The acronym refers to the following features: polyradiculoneuropathy, organomegaly, endocrinopathy, monoclonal paraproteinemia, and skin changes. Methods: The study was conducted at 24 hematological centers across 8 Latin-American countries. The study included a total of 46 patients {median age was 52 years (interquartile range [IQR]: 42 61.5), 30 males and 16 females} fulfilling the POEMS syndrome criteria diagnosed over a period of 12 years (January 1, 2011, through July 31, 2023). Epidemiological and clinical data were collected in an ad hoc database sent to the members of GELAMM, as well as the Kolmogorov-Smirnov test and Kaplan-Meier estimates. Results: All patients had polyneuropathy and monoclonal gammopathy; 89% had bone marrow plasma cell infiltration, 33% had sclerotic b...

artículo

Patients Age 40 Years and Younger with Multiple Myeloma Have the Same Prognosis as Older Patients: An Analysis of Real-World Patients' Evidence from Latin America

Publicado por
Martinez-Cordero, H, Peña, C, Schutz, NP, Bove, V, Villano, F, Beltran, C, Donoso, J, Lopez-Vidal, H, Roa-Salinas, MA, Soto, P, Ochoa, P, Duarte, P, Remaggi, G, Corzo, A, Shanley, C, Lopresti, S, Orlando, S, Verri, V, Quiroga, LD, Fantl, D, Ramirez, J, Ospina-Idarraga, A, Idrobo, H, Quintero, G, Gomez, R, Cantu-Martinez, O, Gomez-Almaguer, D, Ruiz-Arguelles, GJ, Galvez-Cardenas, KM, Salazar, LA, Novoa-Caicedo, I, Fuentes-Lacouture, MC, Spirko, P, Arbelaez, MI, Pereira, M, Valdes, J, Vasquez, J, Von-Glasenapp, A, Riva, E

Publicado 2023

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PURPOSEMultiple myeloma (MM) is a highly heterogeneous, incurable disease most frequently diagnosed in the elderly. Therefore, data on clinical characteristics and outcomes in the very young population are scarce.PATIENTS AND METHODSWe analyzed clinical characteristics, response to treatment, and survival in 103 patients with newly diagnosed MM age 40 years or younger compared with 256 patients age 41-50 years and 957 patients age 51 years or older.RESULTSThere were no statistical differences in sex, isotype, International Scoring System, renal involvement, hypercalcemia, anemia, dialysis, bony lesions, extramedullary disease, and lactate dehydrogenase (LDH). The most used regimen in young patients was cyclophosphamide, bortezomib, dexamethasone, followed by cyclophosphamide, thalidomide, dexamethasone and bortezomib, thalidomide, dexamethasone. Of the patients age 40 years or younger, o...