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The Latin-American Experience in POEMS Syndrome: A Study of the GELAMM (Grupo de Estudio Latinoamericano de Mieloma Múltiple)

Publicado por
Gallardo-Pérez, MM, Negrete-Rodríguez, P, Gertz, MA, Peña, C, Riva, E, Gilli, V, Rodríguez, G, Samánez, C, Ferreira, J, Portiño, S, Montaña, J, León, P, Gutiérrez, Y, Del-Castanhel, C, Seehaus, C, Funes, ME, Meneces-Bustillo, R, Duarte, P, Shanley, C, Elvira, G, Ochoa, P, López-Vidal, H, Martinez-Cordero, H, Vasquez, J, Von-Glasenapp, A, Donoso, J, Viñuela, JL, Ruiz-Delgado, GJ, Ruiz-Argüelles, GJ

Publicado 2024

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Introduction: POEMS syndrome is a rare paraneoplastic syndrome caused by an underlying plasma cell disorder. The acronym refers to the following features: polyradiculoneuropathy, organomegaly, endocrinopathy, monoclonal paraproteinemia, and skin changes. Methods: The study was conducted at 24 hematological centers across 8 Latin-American countries. The study included a total of 46 patients {median age was 52 years (interquartile range [IQR]: 42 61.5), 30 males and 16 females} fulfilling the POEMS syndrome criteria diagnosed over a period of 12 years (January 1, 2011, through July 31, 2023). Epidemiological and clinical data were collected in an ad hoc database sent to the members of GELAMM, as well as the Kolmogorov-Smirnov test and Kaplan-Meier estimates. Results: All patients had polyneuropathy and monoclonal gammopathy; 89% had bone marrow plasma cell infiltration, 33% had sclerotic b...