Resultados de Búsqueda por Autor

artículo

Treatment and Survival Outcomes of Waldenstrom Macroglobulinemia in Latin American Patients: A Multinational Retrospective Cohort Study

Publicado por
Riva E, Duarte PJ, Valcárcel, B, Remaggi, G, Murrieta, I, Corzo, A, Del Carpio, D, Peña, C, Vásquez, J, Bove, V, Teixeira, L, Fleury-Perini, G, Yantorno, S, Samánez, C, Lopresti, S, Altamirano, M, Villela, L, Ruiz-Arguelles, GJ, Ruiz-Delgado, GJ, Montaño, E, Verri, V, Zamora-Pérez, E, Pérez-Jacobo, F, Idrobo, H, Martínez-Cordero, H, Beltran, BE, Ramírez, J, Castillo, JJ, Malpica-Castillo, LE

Publicado 2022

Enlace

PURPOSE: Waldenstrom Macroglobulinemia (WM) is a rare lymphoma with distinct clinical features, and data from Latin American patients are lacking. Therefore, we aim to investigate the clinical, therapy, and outcome patterns of WM in Latin America. METHODS: We retrospectively analyzed patients with WM diagnosed between 1991 and 2019 from 24 centers in seven Latin American countries. The study outcomes were overall survival (OS) and progression-free survival (PFS). RESULTS: We identified 159 cases (median age 67 years, male 62%). Most patients (95%) were symptomatic at diagnosis. The International Prognostic Scoring System for WM (IPSSWM) at diagnosis was available in 141 (89%) patients (high-risk 40%, intermediate-risk 37%, and low-risk 23%). Twenty-seven (17%) patients were tested for MYD88L265P, with 89% (n = 24 of 27) carrying the mutation. First-line and second-line therapies were adm...

artículo

The Latin-American Experience in POEMS Syndrome: A Study of the GELAMM (Grupo de Estudio Latinoamericano de Mieloma Múltiple)

Publicado por
Gallardo-Pérez, MM, Negrete-Rodríguez, P, Gertz, MA, Peña, C, Riva, E, Gilli, V, Rodríguez, G, Samánez, C, Ferreira, J, Portiño, S, Montaña, J, León, P, Gutiérrez, Y, Del-Castanhel, C, Seehaus, C, Funes, ME, Meneces-Bustillo, R, Duarte, P, Shanley, C, Elvira, G, Ochoa, P, López-Vidal, H, Martinez-Cordero, H, Vasquez, J, Von-Glasenapp, A, Donoso, J, Viñuela, JL, Ruiz-Delgado, GJ, Ruiz-Argüelles, GJ

Publicado 2024

Enlace

Introduction: POEMS syndrome is a rare paraneoplastic syndrome caused by an underlying plasma cell disorder. The acronym refers to the following features: polyradiculoneuropathy, organomegaly, endocrinopathy, monoclonal paraproteinemia, and skin changes. Methods: The study was conducted at 24 hematological centers across 8 Latin-American countries. The study included a total of 46 patients {median age was 52 years (interquartile range [IQR]: 42 61.5), 30 males and 16 females} fulfilling the POEMS syndrome criteria diagnosed over a period of 12 years (January 1, 2011, through July 31, 2023). Epidemiological and clinical data were collected in an ad hoc database sent to the members of GELAMM, as well as the Kolmogorov-Smirnov test and Kaplan-Meier estimates. Results: All patients had polyneuropathy and monoclonal gammopathy; 89% had bone marrow plasma cell infiltration, 33% had sclerotic b...