Resultados de Búsqueda por Autor

1

objeto de conferencia

Lesiones premalignas y cáncer de cuello uterino no relacionados al virus del papiloma humano

Publicado por
Taxa, L

Publicado 2024

Cervical cancer is the second most common malignancy in Peruvian women. The new WHO classification divides cervical epithelial neoplasms according to the presence or absence of human papillomavirus (HPV) for both squamous and glandular types. Much has been studied on HPV-related cervical cancer and little in HPV-negative cervical cancer, which, although representing a minority group, is of different behavior and worse prognosis. This review represents an overview of this pathological with emphasis on molecular aspects. Undoubtedly, with the research of this pathology group and mainly molecular development, more specific treatments are expected. © 2024 Peruvian Society of Obstetrics and Gynecology. All rights reserved.

2

artículo

Metallomic profile in non-cirrhotic hepatocellular carcinoma supports a phenomenon of metal metabolism adaptation in tumor cells

Publicado por
Cano L., Bertani S., Island M.-L., Cerapio J.P., Ruiz E., Pineau P., Monbet V., Boudjema K., Taxa L., Casavilca-Zambrano S., Ropert M., Turlin B., Loréal O.

Publicado 2021

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This study was funded by the French National Alliance for Life Sciences and Health (ENV201408); LC was a recipient of a doctoral fellowship from French National Research Institute for Sustainable Development (IRD) (EMHE-ARTS-2016-878573B); JPC was a recipient of a doctoral fellowship from the Peruvian National Council for Science and Technology (212-2015-FONDECYT); SB has received funding from the European Union’s Horizon 2020 Framework program under the Marie Sk?odowska-Curie Actions 823935 and from the Alliance pour les Sciences de la Vie et de la Santé (AVIESAN), ITMO Cancer ENV201408, and LC, ER, and SCZ have received funding from the World Bank Group and FONDECYT-CONCYTEC 016-2018-FONDECYT/BM. The authors are grateful to Karina Cancino, Danny Cordova (INEN Cancer Research Biobank), Patricia Leroyer (NUMECAN), Alain Fautrel, Marine Seffals, Gevorg Ghukasyan (H2P2 platform). They a...

3

artículo

Evaluación de la toxicidad sub aguda del Camu Camu (Myrciaria dubia) administrado por vía oral en ratas.

Publicado por
Roldán, P., Astocóndor, A., Cajaleón, E., Cárdenas, G., Cerna, C., Espinoza, J., Ocaña, R., Hein, M., Castañeda, C. B., Taxa, L. R., Ibañez, V. L., Cruzado, C.

Publicado 2009

Enlace

Introducción: Camu-Camu, es un árbol frutal, oriundo de la amazonla sudamericana que crece en las orillas anegables de rlos amazónicos. Pertenece al genero Myrciaria, especie dubia. Presenta una gran importancia nutritiva. Su alto contenido en ácido ascórbico (2780 mg/lOO g de pulpa) le confieren propiedades antioxidantes.Objetivo: Evaluar la toxicidad subaguda (30 días) del Camu-Camu.Material y método: Utilizamos 33 ratas albinas. macho, Holt<;man, distribuidas en 3 grupos equitativos: Grupo I (grupo control), se leadministró agua destilada, Grupo 11 y Grupo 111, se les administró por vía oral el extracto seco de Camu-Camu a las dosis de 100 y 200mg/Kg, respectivamente. Al inicio del experimento (basal), a los 15 y a los 30 días, se determinó: hemoglobina, WBC, urea, albúmina, creatinina, proteínas, GOT, TGP, TGO, en sangre, y peso corporal; además, serealizó el exam...

4

artículo

Detection of Helicobacter pylori in gastric cancer tissue through histopathology, immunohistochemistry and real-time reverse transcription-PCR

Publicado por
A Castaneda C., Castillo M., Sanchez J., Casavilca S., A Bernabe L., Suarez N., Chavez I., Ruiz E., Tello K., R Villa M., Zevallos R., Montenegro P., Dias-Neto E., Landa-Baella M., Taxa L.

Publicado 2020

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Aim: Helicobacter pylori is usually detected based on hematoxylin-eosin (H-E) features, but, immunohistochemistry (IHC) and real-time PCR (RT-PCR) are more precise in chronic-gastritis. We evaluated the relevance of these tests in Peruvian gastric cancer samples. Materials & methods: We performed and evaluated H-E, IHC staining and RT-PCR in 288 gastric tumors. Slides were independently evaluated by three pathologists. Results: H. pylori was detected in 167/287 through H-E, 140/288 through IHC and 175/288 through RT-PCR, and positive-status were associated (p < 0.001). H. pylori detection by H-E had a good concordance with IHC (kappa index = 0.632) but poor with RT-PCR (kappa index = 0.317). Higher median gene-copies were found in high H. pylori density through H-E or IHC (p < 0.001). Conclusion: H-E evaluation is accurate in gastric cancer, and IHC and RT-PCR can complement its results....

5

artículo

Evaluación de la toxicidad subcrónica del extracto acuoso de las hojas de yacón (Smallanthus sonchifolius) administrado por vía oral en ratas.

Publicado por
Olaciregui P-S, D, Olaciregui P-S, D, Yshikawa K, D, Yshikawa K, D, Padilla F,J, Padilla F,J, Mondoñedo C,C, Mondoñedo C,C, Román A,J, Román A,J, Moya C,R, Moya C,R, Vilela F,J, Vilela F,J, Rivera B,J, Rivera B,J, Morales Z,E, Morales Z,E, Mejía T,D, Mejía T,D, Castañeda C, B, Castañeda C, B, Taxa L, R, Taxa L, R, Manrique, I, Manrique, I, Ibáñez V. L, Ibáñez V. L

Publicado 2009

Enlace

Evaluación de la toxicidad subcrónica del extracto acuoso de las hojas de yacón (Smallanthus sonchifolius) administrado por vía oral en ratas.

6

artículo

Association between Helicobacter pylori infection, mismatch repair, HER2 and tumor-infiltrating lymphocytes in gastric cancer

Publicado por
Castaneda, CA, Castillo, M, Bernabe, LA, Sanchez, J, Fassan, M, Tello, K, Wistuba, II, Passiuri, IC, Ruiz, E, Barreda, F, Valdivia, D, Bazan, Y, Abad-Licham, M, Mengoa, C, Fuentes, H, Montenegro, P, Poquioma, E, Alatrista, R, Flores, CJ, Taxa, L

Publicado 2024

Enlace

BACKGROUND The influence of Helicobacter-pylori (H. pylori) infection and the characteristics of gastric cancer (GC) on tumor-infiltrating lymphocyte (TIL) levels has not been extensively studied. Analysis of infiltrating-immune-cell subtypes as well as survival is necessary to obtain comprehensive information. AIM To determine the rates of deficient mismatch-repair (dMMR), HER2-status and H. pylori infection and their association with TIL levels in GC. METHODS Samples from 503 resected GC tumors were included and TIL levels were evaluated following the international-TILs-working-group recommendations with assessment of the intratumoral (IT), stromal (ST) and invasive-border (IB) compartments. The density of CD3, CD8 and CD163 immune cells, and dMMR and HER2-status were determined by immunohistochemistry (IHC). H. pylori infection was evaluated by routine histology and quantitative PCR (...

7

artículo

Level of tumor-infiltrating lymphocytes and density of infiltrating immune cells in different malignancies

Publicado por
Castaneda C.A., Castillo M., Aliaga K., Bernabe L.A., Casavilca S., Sanchez J., Torres-Cabala C.A., Gomez H.L., Mas L., Dunstan J., Cotrina J.M., Abugattas J., Chavez I., Ruiz E., Montenegro P., Rojas V., Orrego E., Galvez-Nino M., Felix B., Landa-Baella M.P., Vidaurre T., Villa M.R., Zevallos R., Taxa L., Guerra H.

Publicado 2019

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Aim: To correlate levels of tumor-infiltrating lymphocytes (TIL) evaluated using the International Immuno-Oncology Biomarker Working Group methodology, and both density of tumor-infiltrating immune cell and clinicopathological features in different malignancies. Methods: 209 pathological samples from gastric cancer, cervical cancer (CC), non-small-lung cancer, cutaneous melanoma (CM) and glioblastoma were tested for TIL in hematoxylin eosin, and density of CD3+, CD4+, CD8+, CD20+, CD68+ and CD163+ cells by digital analysis. Results: TIL levels were higher in invasive margin compartments (IMC). TIL in IMC, intratumoral and stromal compartments predicted survival. CC and gastric cancer had higher TIL in intratumoral; CC and CM had higher TIL in stromal compartment and IMC. CM had the highest density of lymphocyte and macrophage populations. CD20 density was associated with survival in the ...