Resultados de Búsqueda por Autor

artículo

Level of tumor-infiltrating lymphocytes and density of infiltrating immune cells in different malignancies

Publicado por
Castaneda C.A., Castillo M., Aliaga K., Bernabe L.A., Casavilca S., Sanchez J., Torres-Cabala C.A., Gomez H.L., Mas L., Dunstan J., Cotrina J.M., Abugattas J., Chavez I., Ruiz E., Montenegro P., Rojas V., Orrego E., Galvez-Nino M., Felix B., Landa-Baella M.P., Vidaurre T., Villa M.R., Zevallos R., Taxa L., Guerra H.

Publicado 2019

Enlace

Aim: To correlate levels of tumor-infiltrating lymphocytes (TIL) evaluated using the International Immuno-Oncology Biomarker Working Group methodology, and both density of tumor-infiltrating immune cell and clinicopathological features in different malignancies. Methods: 209 pathological samples from gastric cancer, cervical cancer (CC), non-small-lung cancer, cutaneous melanoma (CM) and glioblastoma were tested for TIL in hematoxylin eosin, and density of CD3+, CD4+, CD8+, CD20+, CD68+ and CD163+ cells by digital analysis. Results: TIL levels were higher in invasive margin compartments (IMC). TIL in IMC, intratumoral and stromal compartments predicted survival. CC and gastric cancer had higher TIL in intratumoral; CC and CM had higher TIL in stromal compartment and IMC. CM had the highest density of lymphocyte and macrophage populations. CD20 density was associated with survival in the ...