rhernand@ulima.edu.pe; mlcacere@ulima.edu.pe; fccarras@ulima.edu.pe; abraham.vaisberg@upch.pe; espodine@ciq.uchile.cl; jmanzur@ing.uchile.cl; hennig@chemic. uni-leipzig.de; sieler@uni-leipzig.de; beyinorg@uni-leipzig.de

rhernand@ulima.edu.pe; beyinorg@chemic.uni-leipzig.de; jpascastillo@yahoo.es; espodine@ciq.uchile.cl; Abraham.vaisberg@upch.pe

rhernand@ulima.edu.pe; fccarras@ulima.edu.pe;vaisberg@upch.pe

Eight new thiosemicarbazone derivatives, 6-(1-trifluoroethoxy)pyridine-3-carbaldehyde thiosemicarbazone (1), 6-(4'-fluorophenyl)pyridine-3-carbaldehyde thiosemicarbazone (2), 5-chloro-pyridine-3-carbaldehyde thiosemicarbazone (3), 2-chloro-5-bromo-pyridine-3-carbaldehyde thiosemicarbazone (4), 6-(3',4'-dimethoxyphenyl)pyridine-3-carbaldehyde thiosemicarbazone (5), 2-chloro-5-fluor-pyridine-3-carbaldehyde thiosemicarbazone, (6), 5-iodo-pyridine-3-carbaldehyde thiosemicarbazone (7), and 6-(3',5'-dichlorophenyl)pyridine-3-carbaldehyde thiosemicarbazone (8) were synthesized, from the reaction of the corresponding pyridine-3-carbaldehyde with thiosemicarbazide. The synthesized compounds were characterized by ESI-Mass, UV-Vis, IR, and NMR (1H, 13C, 19F) spectroscopic techniques. Molar mass values and spectroscopic data are consistent with the proposed structural formulas. The molecular structu...

Corrección del artículo (29 de marzo de 2015): https://doi.org/10.1155/2015/915270

The palladium (II) bis-chelate Pd mathematical equation and platinum (II) tetranuclear mathematical equation complexes of benzaldehyde thiosemicarbazone derivatives have been synthesized, and characterized by elemental analysis and IR, FAB(+)-mass and NMR (¿1H, ¿13C) spectroscopy. The complex mathematical equation [HL2 = m-CN-benzaldehyde thiosemicarbazone] shows a square-planar geometry with two deprotonated ligands (L) coordinated to PdII through the nitrogen and sulphur atoms in a transarrangement, while the complex mathematical equation [HL4 = 4-phenyl-1-benzaldehyde thiosemicarbazone] has a tetranuclear geometry with four tridentate ligands coordinated to four PtII ions through the carbon (aromatic ring), nitrogen, and sulphur atoms where the ligands are deprotonated at the NH group. The in vitro antitumor activity of the ligands and their complexes was determined against differen...

El presente trabajo informa acerca de la preparación, caracterización y actividad anti tu moral de nuevos compuestos orgánicos (ligantes) del tipo tiosemicarbazona, RCH=N-NHC(S)-NH2 [R=pirrol-2-carboxaldehído y tiofeno 2-carboxaldehído] y sus complejos me tálicos de paladio(II). El análisis elemental y las técnicas espectroscópicas de infrarrojo y resonancia magnética nuclear de protón y carbono revelan que los ligantes tiosemicarbazonas están desprotonados y se encuentran enlazados al centro metálico a través de dos áto mos de nitrógeno (N) y azufre (S) en una configuración trans.

With the ligands 4-phenyl-1-(furan-2-carbaldehyde)thiosemicarbazone, HTSC1,(1), 4-phenyl-1-(5'-phenyl-furan-2-carbaldehyde)thiosemicarbazone, HTSC2(2),o-methoxy-benzaldehydethiosemi-carbazone, HTSC3(3), ando-cyano-benzaldehydethiosemicarbazone, HTSC4(4), the correspondingpalladium(II) complexes, Pd(TSC1)2(5), Pd(TSC2)2(6),Pd(TSC3)2(7), and Pd(TSC4)2(8)weresynthesized and characterized by elemental analysis and spectroscopic techniques. The crystal struc-ture of Pd(TSC3)2(7) was determined by single-crystal X-ray diffraction. Complex7shows a square-planar geometry, where two deprotonated ligands are coordinated to the PdIIcenter through the ni-trogen and sulfur atoms in atransarrangement.In vitroantitumor studies against different humantumor cell lines have revealed that the palladium(II) complexes5–8are more cytotoxic (IC50valuesin the range of 0.21 – 3.79µM) than their correspondin...

En el presente trabajo se informa acerca de la preparación y caracterización de los compuestos orgánicos derivados del furaldehído tiosemicarbazona y sus respectivos complejos metálicos de paladio(II) y co bre(II). El análisis elemental y las técnicas espectroscópicas confirman las fórmulas estructurales propuestas para los ligantes orgánicos y sus respectivos complejos de paladio(II) y cobre(II). La actividad biológica in vitro de los ligantes y los complejos metálicos reveló que los complejos de paladio(II), Pd(LF4)2 y Pd(LF5)2 presentan mayor actividad citotóxica in vitro (CI50= 0.28 - 1.23 µM) con respecto a los ligantes frente a diferentes líneas de células tumorales de humano.

Los cánceres de estómago, de mama y de pulmón son los de mayor incidencia en el Perú; se les considera un problema de salud pública. El presente trabajo tiene como objetivo sintetizar, caracterizar y evaluar la actividad antitumoral de nuevos complejos de platino (II) con ligandos derivados del benzofurano 2-/3-/5-carbaldehído tiosemicarbazona.

rhernand@ulima.edu.pe, fccarras@ulima.edu.pe

Ten new thiosemicarbazone derivatives, furan-2-carbaldehyde thiosemicarbazone (1), 3-methyl-furan-2-carbaldehyde thiosemicarbazone (2), 5-hydroxymethyl-furan-2-carbaldehyde thiosemicarbazone (3), 5-trifluoromethyl-furan-2-carbaldehyde thiosemicarbazone (4), 5-nitro-furan-2-carbaldehyde thiosemicarbazone (5), 5-phenyl-furan-2-carbaldehyde thiosemicarbazone (6), 5-(2-fluorophenyl)-furan-2-carbaldehyde thiosemicarbazone (7), 5-(4-methoxyphenyl)-furan-2-carbaldehyde thiosemicarbazone (8), 5-(1-naphthyl)-furan-2-carbaldehyde thiosemicarbazone (9), and 5-(1H-Pyrazol-5-yl)-furan-2-carbaldehyde thiosemicarbazone (10) were synthesized by condensing thiosemicarbazide with the respective furan-2-carbaldehyde in methanol. The prepared compounds were characterized by spectroscopic studies (FT-IR and NMR) and electrospray mass spectrometry. The molecular structures of 2, 6, 7, and 8 have also been det...

La oleorresina es un extracto líquido que se obtiene a partir de ají y pimientos del género Capsicum, para ser usada frecuentemente en la industria alimentaria. En este trabajo se ha descrito la extracción de la oleorresina a partir del ají panca, por el método Soxhlet. El rendimiento de la oleorresina fue de 22,77 %, con el empleo de etanol como solvente extractante. Los capsaicinoides capsaicina y deshidrocapsaicina, presentes en el extracto oleorresina, fueron identificados en etanol a una longitud de onda máxima de 281 nm.

Oleoresin is a liquid extract which is obtained from chili and peppers of genus Capsicum, to be used in the food industry very often. This paper describes the oleoresin extraction from aji panca chili pepper by the Soxhlet method. The yield of oleoresin was 22,77 % using ethanol as extraction solvent. The capsaicinoids ―capsaicin and dihydrocapsaicin― present in the oleoresin were identified in ethanol at a maximum 281 nm wavelength.

rlariosf@ulima.edu.pe;bdiaz@ulima.edu.pe;rchavezu@ulima.edu.pe;cgalvezz@ulima.edu.pe;rhernand@ulima.edu.pe

Indexado en Latindex (Catálogo 2.0) y DOAJ

Four indole-3-carbaldehyde semicarbazone derivatives, 2-((5-bromo-1H-indol-3-yl)methylene)hydrazinecarboxamide (1), 2-((5-chloro-1H-indol-3-yl)methylene)hydrazinecarboxamide (2), 2-((5-methoxy-1H-indol-3-yl)methylene)hydrazinecarboxamide (3), and 2-((4-nitro-1H-indol-3-yl)methylene)hydrazinecarboxamide (4) were synthesized and characterized by ESI-MS and spectroscopic (FT-IR, 1H NMR, and 13C NMR) techniques. The two-dimensional NMR (in acetone-d6) spectral data revealed that the molecules 1 and 2 in solution are in the cisE isomeric form. This evidence is supported by DFT calculations at the B3LYP/6-311++G(d,p) level of theory where it was shown that the corresponding most stable conformers of the synthesized compounds have a cisE geometrical configuration, in both the gas and liquid (acetone and DMSO) phases. The in vitro antibacterial activity of compounds 1–4 was determined against ...

Seven species of lichens such us Umbilicaria aff. calvescens, Hypotrachyna enderythraea, Punctelia graminicola, Cladonia chlorophaea, Xanthoparmelia farinose, Psiloparmelia distincta (rock and tree substrates; rs and ts), and Usnea durietzii were collected from the province of Arequipa - Peru. Their usnic acid (UA) and fatty acid (FA) amounts in methanol-acetone were determined by High-performance liquid chromatography with diode-array detection (HPLC-DAD) and Gas chromatography-flame ionization detector (GC-FID). The antimicrobial activities of these extracts were evaluated against Staphylococcus aureus ATCC strains (43300, 29213, 25923 and 700699), Escherichia coli strains (O157:H7 and ATCC 10536), Salmonella enterica sv typhimurium ATCC 14028, Candida albicans ATCC 90028 and Candida. tropicalis ATCC 750T. In addition, antioxidant capacity was also studied by Total phenolic content (TP...

Eight new phenylisoxazole isoniazid derivatives, 3-(2'-fluorophenyl)isoxazole-5-carbaldehyde isonicotinylhydrazone (1), 3-(2'-methoxyphenyl)isoxazole-5-carbaldehyde isonicotinylhydrazone (2), 3-(2'-chlorophenyl)isoxazole-5-carbaldehyde isonicotinylhydrazone (3), 3-(3'-clorophenyl)isoxazole-5-carbaldehyde isonicotinylhydrazone (4), 3-(4'-bromophenyl)isoxazole-5-carbaldehyde isonicotinylhydrazone (5), 5-(4'-methoxiphenyl)isoxazole-3-carbaldehyde isonicotinylhydrazone (6), 5-(4'-methylphenyl)isoxazole-3-carbaldehyde isonicotinylhydrazone (7), and 5-(4'-clorophenyl)isoxazole-3-carbaldehyde isonicotinylhydrazone (8), have been synthesized and characterized by FT-IR, 1H-NMR, 13C-NMR, and mass spectral data. The 2D NMR (1H-1H NOESY) analysis of 1 and 2 confirmed that these compounds in acetone-d6 are in the trans(E) isomeric form. This evidence is supported by computational calculations which w...

El objetivo del estudio fue evaluar el efecto de la zona agroecológica en las características textiles de la fibra de alpaca (Vicugna pacos), procedente de rebaños de unidades productivas de la Puna seca y Puna húmeda en la región Puno, según sexo y edad. Las muestras fueron obtenidas de 5530 alpacas Huacaya. El Diámetro de fibra (DF), Desviación estándar del diámetro de fibra (DEDF), Coeficiente de variación de diámetro de fibra (CVDF), Finura al hilado (FH), Índice de curvatura (IC) y Desviación estándar del índice de curvatura (DEIC) fueron registrados utilizando el equipo OFDA 2000. Los efectos de la zona agroecológica con relación al sexo y edad (Diente de leche [DL], 2 dientes [2D], 4 dientes [4D] y Boca llena [BLL]) se estimaron mediante un diseño al azar con arreglo factorial y prueba de rango múltiple de Duncan. Los valores de DF se encuentran en el rango de ...