Highly volatile, uncertain, complex and ambiguous environments (VUCA) complicate and condition project management. With the emergence of agile project management, it is proposed to co-construct it with the client's active participation. Two used agile methodologies are Scrum and Kanban. Scrum is based on executing fast, interactive cycles (Sprints) for the incremental construction of products. Kanban promotes the balance of the continuous workflow through synchronizing tasks and seeking perfection. The combined use of Scrum-Kanban facilitates the integration of the best of both approaches. The Theory of Constraints (TOC) proposes a method for managing constraints in a system (Constraint Management). The Drum-Buffer-Rope (DBR) method and Buffer Management are practical applications of this theory. This study seeks to maximize the continuous flow of value (Throughput) in agile project mana...

The current study evaluated factors that explain green entrepreneurship intention (GEI) among 407 university students in Chile, who were presented with an online questionnaire. Thirty-nine questions evaluated their GEI, and the data was analysed using multivariate techniques. Results showed thatconcept development support (CDS), business development support (BDS) and academic training support (ATS) had a positive effect on institutional support (IS). Country support (CS) had a positive effect on self-efficacy (SE). IS did not have a positive effect on SE. Finally, SE had a positive effect on GEI. The model explained 25.3% of GEI. Bootstrapping led support to these results. The effects of CDS, BDS, ATS, CS and SE were positive and significant. Recognizing which factors have a significant effect can be useful to devise university programs aiming to enhance GEI among university students. Th...

“The fractionation of Crotalus durissus collilineatus whole venom through an HPLC chromatographic method enabled the purification of a new V-1 neurotoxin. Inter-CRO (V-1) presents similarity in its primary structure to crotoxin B (CB), suggesting another isoform of this toxin. The aim of this study was to compare V-1 to the crotoxin complex (CA/CB) and CB to elucidate aspects related to its functionality. The homogeneity of the purified protein was confirmed with a molecular mass of 1425.45 Da, further verified by mass spectrometry. The sequence of the protein showed high similarity to other viperid snake venom PLA2 proteins. The results of this study report that V-1 is an uncharacterized novel toxin with different biological activities from CB. V-1 maintained catalytic activity but presented neurotoxic activity as observed by the 2.5-fold increase in twitch tension record compared to ...

The fractionation of Crotalus durissus collilineatus whole venom through an HPLC chromatographic method enabled the purification of a new V-1 neurotoxin. Inter-CRO (V-1) presents similarity in its primary structure to crotoxin B (CB), suggesting another isoform of this toxin. The aim of this study was to compare V-1 to the crotoxin complex (CA/CB) and CB to elucidate aspects related to its functionality. The homogeneity of the purified protein was confirmed with a molecular mass of 1425.45 Da, further verified by mass spectrometry. The sequence of the protein showed high similarity to other viperid snake venom PLA2 proteins. The results of this study report that V-1 is an uncharacterized novel toxin with different biological activities from CB. V-1 maintained catalytic activity but presented neurotoxic activity as observed by the 2.5-fold increase in twitch tension record compared to con...

Introduction: Coronavirus SARS-CoV-2 had an impact on health and education, among other subjects. It caused changes in teaching medicine. The objective of the study was to determine student satisfaction in the subjects of the clinical area in a medical school during the coronavirus SARS-CoV-2 pandemic. Methods: The current study has an observational, descriptive, and cross-sectional design. The sample consisted of 119 students. Inclusion criteria included being a student enrolled in the 2021–2022 semester, between the VI and XII semesters in a medical school. Results: It was found that the median age was 21 years; 68 (57.1%) were men. Overall student satisfaction was 67.1%. High student satisfaction was found in the dimension development of professional skills (84.9%), achievement of student expectations (69.7%), and virtual assistance (67.2%) at a medium level of student satisfaction....

El presente estudio tiene como objetivo identificar los factores asociados a la ansiedad y depresión en pacientes con síndrome coronario agudo (SCA) al alta hospitalaria de un centro de salud peruano. Los pacientes al alta del servicio de hospitalización de cardiología entre noviembre de 2019 y diciembre de 2020 fueron evaluados mediante un estudio transversal. La mediana de tiempo transcurrido desde el evento de SCA hasta la fecha de la entrevista fue de 10 meses. El 34,1% de la población presentó depresión leve y el 78,8% ansiedad leve. Nuestros tres análisis indicaron que los pacientes que habían asistido a la universidad tenían niveles significativamente más bajos tanto de depresión como de ansiedad, y los pacientes con diabetes tenían niveles significativamente más altos de ansiedad. El grupo socioeconómico bajo-bajo tuvo 1,5 veces más frecuencia de depresión ( p-va...

El presente estudio tiene como objetivo identificar los factores asociados a la ansiedad y depresión en pacientes con síndrome coronario agudo (SCA) al alta hospitalaria de un centro de salud peruano. Los pacientes al alta del servicio de hospitalización de cardiología entre noviembre de 2019 y diciembre de 2020 fueron evaluados mediante un estudio transversal. La mediana de tiempo transcurrido desde el evento de SCA hasta la fecha de la entrevista fue de 10 meses. El 34,1% de la población presentó depresión leve y el 78,8% ansiedad leve. Nuestros tres análisis indicaron que los pacientes que habían asistido a la universidad tenían niveles significativamente más bajos tanto de depresión como de ansiedad, y los pacientes con diabetes tenían niveles significativamente más altos de ansiedad. El grupo socioeconómico bajo-bajo tuvo 1,5 veces más frecuencia de depresión ( p-va...

Introduction: Latin America was the region most affected by COVID-19 in the second quarter of 2020, and consequently, the impact on mental health requires evaluation. The aim of this study was to assess the risk of post-traumatic stress disorder (PTSD) caused by bereavement due to COVID-19 in 12 countries in Latin America. Methods: The current study was an analytical cross-sectional study. Validated tests were applied for PTSD, depression, anxiety, and stress (DASS-21), questions about the respondent’s condition or their environment, and demographic questions, as well as the length of the mourning period of suffering. Results: The outcomes demonstrated that the PTSD risk increased for women (p < 0.001), when a friend or acquaintance had COVID-19 (p = 0.002), when a close relative died from COVID-19 (p = 0.010), having severe depression (p <0.001), severe anxiety (p <0.001), severe stre...

Corporations need to understand the factors that influence purchase intention. The current study aimed to understand sustainable clothing patterns in Ecuador. A total of 343 Ecuadorian consumers completed an online survey; the results were analyzed with partial least squares structural equation modeling (PLS-SEM). As the outcome, attitude was predicted by perceived environmental knowledge (PEK) and environmental concern (EC). PEK and EC are positively correlated to attitudes towards purchasing sustainable clothing. Additionally, attitude mediated the relationship between these two variables and purchase intention. As measured by PEK, attitude is the most critical factor in determining purchase intention, based on importance performance map analysis (IPMA). The research findings may support firms’ marketing and selling strategies to demonstrate that their brands are environmentally gree...

“In the last decade, the green synthesis of nanoparticles has had a prominent role in scientific research for industrial and biomedical applications. In this current study, silver nitrate (AgNO3 ) was reduced and stabilized with an aqueous extract of Thelypteris glandulosolanosa (Raqui-raqui), forming silver nanoparticles (AgNPs-RR). UV-vis spectrophotometry, dynamic light scattering (DLS), and scanning transmission electron microscopy (STEM) were utilized to analyze the structures of AgNPsRR. The results from this analysis showed a characteristic peak at 420 nm and a mean hydrodynamic size equal to 39.16 nm, while the STEM revealed a size distribution of 6.64–51.00 nm with an average diameter of 31.45 nm. Cellular cytotoxicity assays using MCF-7 (ATCC® HTB-22™, mammary gland breast), A549 (ATCC® CCL-185, lung epithelial carcinoma), and L929 (ATCC® CCL-1, subcutaneous connective...

Corporations need to understand the factors that influence purchase intention. The current study aimed to understand sustainable clothing patterns in Ecuador. A total of 343 Ecuadorian consumers completed an online survey; the results were analyzed with partial least squares structural equation modeling (PLS-SEM). As the outcome, attitude was predicted by perceived environmental knowledge (PEK) and environmental concern (EC). PEK and EC are positively correlated to attitudes towards purchasing sustainable clothing. Additionally, attitude mediated the relationship between these two variables and purchase intention. As measured by PEK, attitude is the most critical factor in determining purchase intention, based on importance performance map analysis (IPMA). The research findings may support firms’ marketing and selling strategies to demonstrate that their brands are environmentally gree...

“In the last decade, the green synthesis of nanoparticles has had a prominent role in scientific research for industrial and biomedical applications. In this current study, silver nitrate (AgNO3 ) was reduced and stabilized with an aqueous extract of Thelypteris glandulosolanosa (Raqui-raqui), forming silver nanoparticles (AgNPs-RR). UV-vis spectrophotometry, dynamic light scattering (DLS), and scanning transmission electron microscopy (STEM) were utilized to analyze the structures of AgNPsRR. The results from this analysis showed a characteristic peak at 420 nm and a mean hydrodynamic size equal to 39.16 nm, while the STEM revealed a size distribution of 6.64–51.00 nm with an average diameter of 31.45 nm. Cellular cytotoxicity assays using MCF-7 (ATCC® HTB-22™, mammary gland breast), A549 (ATCC® CCL-185, lung epithelial carcinoma), and L929 (ATCC® CCL-1, subcutaneous connective...

We performed an analytical, cross-sectional study of 285 consumers to assess the influence of social influence, resistance to use, facilitators to use, perceived ease of use and perceived usefulness of telemedicine on the intention to use telemedicine of citizens of Argentina in times of the pandemic by COVID-19. The proposed research model was analyzed using partial least square structural equation modeling (PLS-SEM). Perceived ease of use had a positive effect (0.624) on perceived usefulness; facilitating conditions had a positive effect (0.476) on usage intention; perceived risk (-0.062) and social influence (0.072) did not have an effect on usage intention. Bootstrapping showed that the beta coefficients were statistically significant. The outcomes may provide ideas to healthcare managers to know what an expectation about telemedicine is and develop new services directed to patients....

“In the present investigation, an ethanolic fraction (EF) of Lepechinia meyenii (salvia) was prepared and fractionated by gradient column chromatography, and the main secondary metabolites present in the EF were identified by HPLC-MS. Silver nanoparticles (AgNPs) were synthesized and conjugated with the EF of Lepechinia meyenii (salvia). The AgNPs synthesis was optimized using Plackett-Burman design and response surface methodology (RSM), considering the following independent variables: stirring speed, synthesis pH, synthesis time, synthesis temperature and EF volume. The AgNPs synthesized under the optimized conditions were characterized by UV visible spectroscopy (UV-VIS), Fourier Transform Infrared Spectroscopy (FT-IR), Dynamic Light Scattering (DLS) and Scanning Transmission Electron Microscopy (STEM). The antibacterial activity of the AgNPs against Staphylococcus aureus (ATCC® 25...

“In the present investigation, an ethanolic fraction (EF) of Lepechinia meyenii (salvia) was prepared and fractionated by gradient column chromatography, and the main secondary metabolites present in the EF were identified by HPLC-MS. Silver nanoparticles (AgNPs) were synthesized and conjugated with the EF of Lepechinia meyenii (salvia). The AgNPs synthesis was optimized using Plackett-Burman design and response surface methodology (RSM), considering the following independent variables: stirring speed, synthesis pH, synthesis time, synthesis temperature and EF volume. The AgNPs synthesized under the optimized conditions were characterized by UV visible spectroscopy (UV-VIS), Fourier Transform Infrared Spectroscopy (FT-IR), Dynamic Light Scattering (DLS) and Scanning Transmission Electron Microscopy (STEM). The antibacterial activity of the AgNPs against Staphylococcus aureus (ATCC® 25...

Introduction: The COVID-19 pandemic has accelerated universities' adaptation process toward online education, and it is necessary to know the students' attitudes toward this online education. Objective: To describe the evolution of the attitude toward online education among social science students at a public university in Peru in the academic year 2020, in the context of the COVID-19 pandemic. Methods: The study uses a quantitative approach, a descriptive level, a non-experimental design, and a longitudinal trend. The sample consisted of 1063 students at the beginning of the class period, 908 during the classes, and 1026 at the end of the class period. The questionnaire for data collection was the Attitude scale toward online education for university students during the COVID-19 pandemic. The data was collected using Google Forms. Results: As a result, the attitude towards online educat...

Tere is evidence that vaccine acceptability is strongly associated with mental health. However, no studies assessing intention to vaccinate (ITV) intention toward children of military parents have been documented. Te current research aimed to establish the prevalence and factors of ITV children against COVID-19 in military parents in Lambayeque-Peru, 2021. Analysis was conducted with the dependent variable ITV children reported by military parents. Te independent variables were history of mental health, searching for mental health support, food insecurity, resilience, anxiety, depression, burnout, posttraumatic stress, and suicidal risk. Prevalence ratios and 95% confdence intervals were estimated. Of 201 military personnel evaluated, 92.5% were male, 82.5% were of the Catholic faith, and the median age was 40.9% of respondents reported seeking mental health help during the COVID-19 pand...

We aimed to identify the factors associated with mortality in patients with COVID-19 from the hospitalization service of the Cayetano Heredia Hospital, Piura, Peru, from May to June 2020. A prospective study was conducted in hospitalized patients with a confirmed diagnosis of COVID-19 through serological and/or molecular reactive testing. The dependent variable was death due to COVID-19, and the independent variables were the epidemiological, clinical and laboratory characteristics of the patient. The chi-square test and the non-parametric Mann–Whitney U test were used, with a significance level of 5%. Of 301 patients with COVID-19, the majority of them were male (66.1%), and the mean age was 58.63 years. Of the patients analyzed, 41.3% of them died, 40.2% of them were obese and 59.8% of them had hepatic steatosis. The three most frequent signs/symptoms were dyspnea (90.03%), fatigue (...

The aim of this study was to provide additional data on mortality from COVID-19 with particular attention to the factors associated with the positivity of patients admitted to the Lambayeque Hospital in Peru. A retrospective cohort analysis was carried out to determine the clinical-epidemiological factors associated with positivity for SARS-CoV-2 in patients treated at the Lambayeque Regional Hospital during the health emergency period in the context of the COVID-19 pandemic. It was observed that, as the demographic age group increased, the percentage of seropositivity increased, with 66.8% of elderly adults testing positive, compared to 37.4% of children (p < 0.001). More seropositive men than women were evident (61.1% vs. 54.1%; p < 0.001). The most frequent symptom of patients with suspected COVID-19 was cough (65.0%). However, the symptoms with the greatest frequency of seropositive ...

The aim of this study was to provide additional data on mortality from COVID-19 with particular attention to the factors associated with the positivity of patients admitted to the Lambayeque Hospital in Peru. A retrospective cohort analysis was carried out to determine the clinical-epidemiological factors associated with positivity for SARS-CoV-2 in patients treated at the Lambayeque Regional Hospital during the health emergency period in the context of the COVID-19 pandemic. It was observed that, as the demographic age group increased, the percentage of seropositivity increased, with 66.8% of elderly adults testing positive, compared to 37.4% of children (p < 0.001). More seropositive men than women were evident (61.1% vs. 54.1%; p < 0.001). The most frequent symptom of patients with suspected COVID-19 was cough (65.0%). However, the symptoms with the greatest frequency of seropositive ...