Introducción: El síndrome de McCune-Albright (SMA) es una enfermedad rara caracterizada por la triada: manchas cutáneas de color café con leche, displasia fibrosa poliostótica y pubertad precoz. Puede afectar a diversos ejes hormonales, entre ellos el de la hormona de crecimiento (GH), pudiendo asociarse a acromegalia. Reporte de caso: describimos el caso de una mujer de 44 años, con pubertad precoz periférica, hemorragia uterina anormal, crecimiento de manos y pies, prognatismo, prominencia frontal, manchas café con leche y tumoraciones pétreas en cara y antebrazos. Resultados: Apoyados con exámenes laboratoriales y de imágenes, se llegaron a los diagnósticos de acromegalia, hipogonadismo hipogonadotropo y síndrome de McCune-Albright. La paciente fue sometida a tratamiento quirúrgico con persistencia de enfermedad clínica y laboratorial. Conclusión: El diagnóstico y tra...

Background: McCune-Albright syndrome (MAS) is a rare disease characterized by the triad: café-au-lait skin spots, polyostotic fibrous dysplasia, and precocious puberty. It can affect various hormonal axes, including growth hormone (GH), and may be associated with acromegaly. Case report : We describe the case of a 44-year-old woman with peripheral precocious puberty, abnormal uterine bleeding, growth of the hands and feet, prognathism, frontal prominence, café-au-lait spots, and stony tumors on the face and forearms. Results: Supported by laboratory and imaging tests, the diagnoses of acromegaly, hypogonadotropic hypogonadism and McCune-Albright syndrome were reached. The patient underwent surgical treatment with persistence of clinical and laboratory disease. Conclusion: Timely diagnosis and treatment of acromegaly and its complications will provide a better prognosis for patients wi...

The main objective of the present non-experimental research and descriptive retrospective design is to describe the clinical-epidemiological characteristics of adult patients with dengue in Trujillo. To this end, the clinical histories of patients with dengue treated at the MINSA level III hospitals of the city of Trujillo were reviewed. The data was recorded in a data collection matrix and the results were expressed as percentage values. It was found that 64% of patients were women, the average age was 35.5 years and the age group most affected was between 18-30 years (51%). The most common provenance was from the districts of El Porvenir (25.5%) and Florencia de Mora (20.6%). 91% of the cases were dengue with warning signs. The most common clinical and laboratory findings were headache (76.7%), thrombocytopenia (75.2%). The most frequent warning signs were: plaquetopenia (82.2%), abdom...

Investigación de tipo no experimental y diseño retrospectivo que tuvo como objetivo principal describir las características clínico-epidemiológicas de los pacientes adultos con dengue en Trujillo. Se revisaron historias clínicas de los pacientes con dengue atendidos en los hospitales MINSA nivel III de la ciudad de Trujillo. De 141 pacientes seleccionados, se encontró que el 64% fueron mujeres, el promedio de edad fue 35.5 años y el grupo etáreo más afectado fue el comprendido entre los 18-30 años (51%). La procedencia más común fueron de los distritos de El Porvenir (25.5%) y Florencia de Mora (20.6%). 91% de los casos fueron pacientes con de  ngue con signos de alarma. Los hallazgos clínicos y de laboratorio más comunes fueron cefalea (76.7%), plaquetopenia (75.2%). Los signos de alarma más frecuentes fueron: plaquetopenia (82.2%), dolor abdominal (64.3%). Palabras...

Investigación de tipo no experimental y diseño retrospectivo que tuvo como objetivo principal describir las características clínico-epidemiológicas de los pacientes adultos con dengue en Trujillo. Se revisaron historias clínicas de los pacientes con dengue atendidos en los hospitales MINSA nivel III de la ciudad de Trujillo. De 141 pacientes seleccionados, se encontró que el 64% fueron mujeres, el promedio de edad fue 35.5 años y el grupo etáreo más afectado fue el comprendido entre los 18-30 años (51%). La procedencia más común fueron de los distritos de El Porvenir (25.5%) y Florencia de Mora (20.6%). 91% de los casos fueron pacientes con de  ngue con signos de alarma. Los hallazgos clínicos y de laboratorio más comunes fueron cefalea (76.7%), plaquetopenia (75.2%). Los signos de alarma más frecuentes fueron: plaquetopenia (82.2%), dolor abdominal (64.3%). Palabras...

Background: Primary aldosteronism is a disorder due to excessive aldosterone production in the presence of low renin levels. It is an underdiagnosed pathology despite its simple screening. Establishing the unilateral or bilateral location represents the greatest diagnostic challenge and is crucial to define the therapeutic approach. Adrenal venous catheterization (AVC) is the best test to establish the location, but it is invasive and expensive. New predictive markers of laterality are being developed. Case series presentation: We present a case series of 8 patients diagnosed with primary aldosteronism due to arterial hypertension with hypokalaemia, elevated aldosterone-renin ratio and compatible computed tomography. 4 patients underwent adrenal venous catheterization. Conclusion: In patients who underwent catheterization as well as in those who did not, the Küpers score adequately pred...

Background: Primary aldosteronism is a disorder due to excessive aldosterone production in the presence of low renin levels. It is an underdiagnosed pathology despite its simple screening. Establishing the unilateral or bilateral location represents the greatest diagnostic challenge and is crucial to define the therapeutic approach. Adrenal venous catheterization (AVC) is the best test to establish the location, but it is invasive and expensive. New predictive markers of laterality are being developed. Case series presentation: We present a case series of 8 patients diagnosed with primary aldosteronism due to arterial hypertension with hypokalaemia, elevated aldosterone-renin ratio and compatible computed tomography. 4 patients underwent adrenal venous catheterization. Conclusion: In patients who underwent catheterization as well as in those who did not, the Küpers score adequately pred...

Introducción: La obesidad en niños y adolescentes ha aumentado exponencialmente en todo el mundo. Asimismo, la pandemia del coronavirus (COVID-19) ha conducido a una mayor tasa de obesidad pediátrica. El exceso de tejido adiposo genera una desregulación de hormonas como adiponectina, ghrelina y leptina, entre otras. Las alteraciones metabólicas pueden ocasionar enfermedad cardiovascular, dislipidemias, hipertensión arterial, diabetes mellitus tipo 2, enfermedad del hígado graso no alcohólico, trastornos del sueño y mayor riesgo de COVID-19 severo. La obesidad tiene diferentes enfoques terapéuticos, como programas conductuales de pérdida de peso, tratamientos farmacológicos y procedimientos quirúrgicos. De esta manera, el diagnóstico y el tratamiento oportuno es importante para disminuir la mortalidad asociada a la obesidad en la población pediátrica.

Obesity in children and adolescents has increased exponentially around the world. Furthermore, the COVID-19 pandemic has led to a higher pediatric obesity rate. The excess adipose tissue generates a dysregulation of adiponectin, ghrelin, and leptin, among others. Metabolic alterations can develop cardiovascular disease, dyslipidemias, arterial hypertension, type 2 diabetes mellitus, nonalcoholic fatty liver disease, sleep disorders, and higher risk of COVID-19 severity. Obesity has different therapeutic approaches such as behavioral weight loss programs, pharmacologic treatments, and surgical procedures. Therefore, timely diagnosis and treatment are important to decrease the mortality in obesity among pediatric population.

Background: Obesity in children and adolescents has increased exponentially around the world. Furthermore, the COVID-19 pandemic has led to a higher pediatric obesity rate. The excess adipose tissue generates a dysregulation of adiponectin, ghrelin, and leptin, among others. Metabolic alterations can develop cardiovascular disease, dyslipidemias, arterial hypertension, type 2 diabetes mellitus, nonalcoholic fatty liver disease, sleep disorders, and higher risk of COVID-19 severity. Obesity has different therapeutic approaches such as behavioral weight loss programs, pharmacologic treatments, and surgical procedures. Therefore, timely diagnosis and treatment are important to decrease the mortality in obesity among pediatric population.