Acromegaly due to pituitary macroadenoma in a patient with McCune-Albright syndrome. Case report and literature overview

• Autores: Alcalde-Loyola, Carlos, Ramos-Yataco, Anthony, Ildefonso-Najarro, Sofía, Gallardo-Rojas, Wilson, Concepción-Urteaga, Luis, Concepción-Zavaleta, Marcio, Rios-Rojas, Jeniffer
• Formato: artículo
• Fecha de Publicación: 2022
• Institución: Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo
• Repositorio: Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo
• Lenguaje: español
• OAI Identifier: oai:cmhnaaa_ojs_cmhnaaa.cmhnaaa.org.pe:article/1136
• Enlace del recurso: https://cmhnaaa.org.pe/ojs/index.php/rcmhnaaa/article/view/1136
• Nivel de acceso: acceso abierto
• Materia: Acromegalia; Adenoma Hipofisario Secretor de Hormona de crecimiento; displasia fibrosa poliostótica; Growth Hormone-Secreting Pituitary Adenoma; Fibrous Dysplasia; Polyostotic

Background: McCune-Albright syndrome (MAS) is a rare disease characterized by the triad: café-au-lait skin spots, polyostotic fibrous dysplasia, and precocious puberty. It can affect various hormonal axes, including growth hormone (GH), and may be associated with acromegaly. Case report : We describe the case of a 44-year-old woman with peripheral precocious puberty, abnormal uterine bleeding, growth of the hands and feet, prognathism, frontal prominence, café-au-lait spots, and stony tumors on the face and forearms. Results: Supported by laboratory and imaging tests, the diagnoses of acromegaly, hypogonadotropic hypogonadism and McCune-Albright syndrome were reached. The patient underwent surgical treatment with persistence of clinical and laboratory disease. Conclusion: Timely diagnosis and treatment of acromegaly and its complications will provide a better prognosis for patients with MAS.