1
artículo
Publicado 2017
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Un amplificador de potencia de dos etapas de clase AB en cascada operando a 2.4Ghz fue diseñado para un proceso de CMOS de 130nm para aplicaciones Bluetooth de Clase-1. El amplificador de poder fue polarizado en una clase AB para un mejor punto medio entre linealidad y eficiencia. El amplificador de potencia propuesto tiene una eficiencia total de 39.6%, una ganancia de potencia de 25dB y una salida de poder de 20dBm.
2
tesis de grado
Publicado 2017
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El Perú es un país pluricultural gracias a las constantes migraciones por las que ha pasado a través de los años esto lleva a que la cultura sea un tema importante para el desarrollo del país ,pero existen problemas como el poco interés de las nuevas generaciones en aprender sobre sus raíces o también la escases de equipamientos con adecuadas instalaciones para una correcta enseñanza de la cultura ,lo que en Arequipa una ciudad con fuerte carácter cultural se ve reflejado en que la mayoría de los equipamientos culturales se encuentran ubicados en el centro histórico o zonas aledañas provocando que zonas más alejadas de la ciudad no tengan un acceso inmediato a estos servicios y generando en la población una falta de identidad hacia la ciudad por eso “la Casa de la Cultura “ esta propuesta como parte de una red de equipamientos ubicados en través la ciudad para de algu...
3
artículo
Publicado 1974
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In Condebamba Valley (Cajamarca) between February and July 1973; 69 crabs Pseudothelphusa chilensis were collected, of them (34 males and 35 females) 22 (64.7%) males and 29 (28.85%) females were infected with metacercariae, this results are consistent with Cuba et al. (1974) report.
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artículo
The support of the Peruvian Scholarship program UNI-agreement No 167 - 2015 – Fondecyct-UNI, CONCYTEC (Lima, Perú) is gratefully acknowledged. AFL acknowledges the support from the Brazilian funding agencies CNPq, FAPESP and CAPES.
5
artículo
Publicado 2017
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Introducción. La publicación científica se debe incentivar desde el pregrado, sobre todo en carreras de ciencias de la salud. Objetivo. Determinar las características y los factores asociados a la publicación científica entre los miembros de la Asociación Científica de Estudiantes de Medicina de Colombia (ASCEMCOL). Materiales y métodos. Se realizó un estudio transversal analítico que se basó en una encuesta presencial aplicada a los miembros de la ASCEMCOL. Se definió como publicación la realizada en una revista científica indexada; la información recolectada se cruzó con variables para obtener estadísticos de asociación. Resultados. Al realizar el análisis multivariado, se asoció a mayor participación en investigaciones científicas el encontrarse en un semestre académico superior (RPa: 1.25; IC95%: 1.01-1.56; p=0.043) y tener más cantidad de investigaciones ext...
6
artículo
Publicado 2018
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The authors are grateful to the São Paulo Research Foundation (FAPESP, Brazil) for funding projects n° 2016/18052-5 and 2014/16998-3 and the L.H. Campestrini post-doctoral fellowship (2011/51707-1); the National Council for Scientific and Technological Development (CNPq, Brazil) for funding the project n° 401004/2014-7; Cienciactiva for the A.C. Miano Ph.D. scholarship (Contract 272-2015-FONDECYT) and E. Saldaña Ph.D Scholarship (Contract 104-2016-FONDECYT) from the “Consejo Nacional de Ciencia, Tecnología e Inovación Tecnológica" (CONCYTEC, Peru). The authors are also grateful to the “Núcleo de Apoio à Pesquisa em Microscopia Eletrônica Aplicada à Pesquisa Agropecuária” (NAP/MEPA-ESALQ/USP) for the support and facilities of Electronic Microscopy; to the Laboratório Multiusuário em Produção Vegetal (ESALQ/USP) for the mineral determination analysis and to Prof. Dr. ...
7
artículo
Publicado 2024
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El estudio tuvo por objetivo evaluar la eficacia de cuatro antihelmínticos en el control de Fasciola hepatica en la Estación Experimental del Instituto Nacional de Innovación Agraria (INIA), Baños del Inca, Cajamarca, Perú. Se utilizaron 40 cuyes de 5 a 12 meses de edad, de la línea Inka infectados naturalmente con F. hepatica (>1 HPG) no desparasitados en los últimos 4 meses, bajo el mismo sistema de manejo y alimentación. Los cuyes fueron distribuidos en cuatro grupos (n=10): triclabendazol (25 mg/kg), closantel (20 mg/kg) vía oral, clorsulón + ivermectina (15 mg/kg en base a clorsulón) y nitroxinil (50 mg/kg), vía subcutánea. Se determinó la carga parasitaria el día 0 y 30 posdosificación. El Test de Reducción del Conteo de Huevos determinó una eficacia de 0% para triclabendazol y 100% para closantel, clorsulón + ivermectina, y nitroxinil. Se concluye F. hepatica es...
8
artículo
Publicado 2023
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The aim of this study was to determine the efficacy of three frequently drugs used in the control of nematodes in guinea pigs at the Baños del Inca Experimental Station of the National Institute of Agricultural Innovation (INIA), Cajamarca. Forty male guinea pigs of the Inka line between 2 to 3 months of age, positive for Trichuris spp and Paraspidodera uncinata, naturally infected, and reared within the same management and feeding system were used. The guinea pigs were homogeneously distributed according to the number of eggs per gram of faeces in 20 positive for Paraspidodera uncinata and 20 for Trichuris spp, distributed in four groups of five each. The treatments were T0: control group, not dosed; T1: fenbendazole 20 mg/kg, PO; T2: oxfendazole 20 mg/kg, PO; and T3: ivermectin 0.5 mg/kg, SQ. The evaluation was carried out by necropsy on day 10 of dosing using the the Randomized Contr...
9
artículo
Publicado 2021
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Funding: The authors thank the Fondo Nacional de Desarrollo Científico, Tecnológico y de Inno-vación Tecnológica (PROCIENCIA-CONCYTEC), project number: 177-2020-FONDECYT (PROCIEN-CIA), project CLEAN NANOMAGNETIC. “The APC was funded by PROCIENCIA”.
10
artículo
Publicado 2021
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The present study aimed to characterize the guinea pig breeding system in three provinces of the Cajamarca Region, Peru. A structured survey was applied to 1231 producers (401 from Cajamarca, 360 from San Marcos and 470 from Cajabamba). The predominant production system is family-commercial (67% of producers). The Peru breed is preferred by producers, rearing the animals in pools. Most of the producers have less than 49 guinea pigs in a 0.5 to 5 ha land area. Alfalfa (Medicago sativa) being the forage most used in the feeding of guinea pigs. More than 80% of producers do not receive technical assistance and more than 87% are not part of a breeder association. In the sanitary characterization, 1 to 5 guinea pigs die per week and per producer, especially in the lactating class. The most reported disease is salmonellosis, which is identified by alterations in the liver.
11
artículo
Publicado 2021
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This work was carried out with partial financial support from Fundaçăo de Amparo à Pesquisa do Estado de Săo Paulo - FAPESP, Brazil (Process number 2014/03085–0 ). To Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq, Brazil , for fellowship to C.D. Gonzales-Lorenzo (Process number 162741/2015–4 ). The authors would like to express our thanks to Dr. H. Loro from the National Engineering University (UNI), Peru, for allowing us to use the appropriate equipment for optical absorption measurements. Besides, C.D. Gonzales-Lorenzo kindly acknowledges the partial financial support from Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica (CONCYTEC) - Banco Mundial , through its executing unit FONDECYT , Peru (Process number 037-2019-FONDECYT-BM-INC.INV.). A.F. Zatsepin and A.N. Kiryakov were supported by the Russian Science Foundation (Grant N° 21-12...
12
artículo
Publicado 2025
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The aim of this study was to evaluate the effect of protein supplementation at service and before delivery on the load of gastrointestinal nematodes in naturally infested dairy goats. Two groups of 17 goats were evaluated: control group (SinSu) without supplementation and supplemented (ConSu) with 19% protein during service and 45 days prepartum. The animals were monitored every 15 days during service and in the 45 days before lambing and monthly during the rest of the trial. The parasitic load (eggs per gram of feces – epg) and their differentiation into genus were determined, in addition to the hematocrit, total proteins, body condition (BCS) and clinical and Famacha grade. The weight of the offspring and milk production at 90 days were recorded. No significant differences were found in epg of the two groups before lambing, but protein supplementation resulted in a lower parasitic lo...
13
artículo
Publicado 2024
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Introduction: ALK tyrosine kinase inhibitors have exhibited promising activity against advanced ALK-rearranged NSCLC. However, co-occurring genetic alterations, such as CDKN2A/B or TP53, may negatively affect the efficacy of targeted therapies. Methods: From December 2017 to December 2022, this study cohort analyzed next-generation sequencing data of 116 patients with metastatic ALK-rearranged NSCLC from five Latin American cancer centers. Clinicopathologic and molecular features were associated with clinical outcomes and risk of brain metastasis (BrM) in patients with and without concurrent somatic alterations. Results: All patients (N = 116) received a second-generation ALK tyrosine kinase inhibitor, and alectinib was selected in 87.2% of cases. Coalterations occurred in 62% of the cases; the most frequent were TP53 mutations (27%) and CDKN2A/B loss (18%). The loss of CDKN2A/B was asso...
14
artículo
Publicado 2022
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Objectives: To compare the rate disparity between outcomes (overall survival (OS), progression-free survival (PFS), and safety) of concurrent chemoradiation (cCRT) followed by durvalumab in two patient cohorts with locally advanced (LA) stage III non-small cell lung cancer (NSCLC), one non-Hispanic White (NHW), and the other Latin-American. Methods: A multicenter retrospective study was performed, including 80 Hispanic and 45 NHW LA stage III NSCLC patients treated with cCRT followed by durvalumab. Both cohorts were analyzed in terms of main outcomes (OS, PFS, and safety) and compared between them and with the PACIFIC trial population outcomes. The efficacy-effectiveness gap was assessed using an efficacy-effectiveness (EE) factor that was calculated by dividing each cohort median overall survival by the corresponding reference OS from the PACIFIC trial. In both cohorts, results of PD-L1...
15
artículo
Publicado 2021
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Purpose: COVID-19 has affected cancer care worldwide. Clinical trials are an important alternative for the treatment of oncologic patients, especially in Latin America, where trials can be the only opportunity for some of them to access novel and, sometimes, standard treatments.Methods: This was a cross-sectional study, in which a 22-question survey regarding the impact of the COVID-19 pandemic on oncology clinical trials was sent to 350 representatives of research programs in selected Latin American institutions, members of the Latin American Cooperative Oncology Group.Results: There were 90 research centers participating in the survey, with 70 of them from Brazil. The majority were partly private or fully private (n = 77; 85.6%) and had confirmed COVID-19 cases at the institution (n = 57; 63.3%). Accruals were suspended at least for some studies in 80% (n = 72) of the responses, mostly...
16
artículo
When breast cancer is detected and treated early, the chances of survival are very high. However, women in many settings face complex barriers to early detection, including social, economic, geographic, and other interrelated factors, which can limit their access to timely, affordable, and effective breast health care services. Previously, the Breast Health Global Initiative (BHGI) developed resource-stratified guidelines for the early detection and diagnosis of breast cancer. In this consensus article from the sixth BHGI Global Summit held in October 2018, the authors describe phases of early detection program development, beginning with management strategies required for the diagnosis of clinically detectable disease based on awareness education and technical training, history and physical examination, and accurate tissue diagnosis. The core issues address include finance and governanc...
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artículo
Publicado 2021
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Background: Thymomas are a group of rare neoplasms of the anterior mediastinum. The objective of this study was to describe the demographics, clinical characteristics and treatment approaches in Latin America.Methods: This was a retrospective multicenter cohort study including patients with histologically proven thymomas diagnosed between 1997 and 2018. Demographics, clinicopathological characteristics and therapeutic outcomes were collected locally and analyzed in a centralized manner. Results: A total of 135 patients were included. Median age at diagnosis was 53 years old (19-84), 53.3% (n = 72) of patients were female and 87.4% had an ECOG performance score ranging from 0-1. A total of 47 patients (34.8%) had metastatic disease at diagnosis. Concurrent myasthenia gravis occurred in 21.5% of patients. Surgery was performed in 74 patients (54.8%), comprising 27 (20%) tumorectomies and 4...
18
artículo
Publicado 2022
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Background: Mutations in STK11 (STK11Mut) and, frequently co-occurring, KEAP1 mutations (KEAP1Mut) are associated with poor survival in metastatic Non-small Cell Lung Cancer (mNSCLC) patients treated with immunotherapy. However, there are limited data regarding the prognostic or predictive significance of these genomic alterations among Hispanics. Methods: This retrospective study analyzed a cohort of Hispanic patients (N = 103) diagnosed with mNSCLC from the US and seven Latin American countries (LATAM) treated with immune checkpoint inhibitors (ICI) alone or in combination as first-line (Cohort A). All cases were treated in routine care between January 2016 and December 2021. The main objectives were to determine the association of mutations in STK11 or KEAP1 in these patients’ tumors with overall (OS) and progression-free survival (PFS), presence of KRAS mutations, tumor mutational ...
19
libro
Publicado 2021
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Con el objetivo de tener un manual sobre el mercado europeo de paiche de Perú, el Programa Nacional de Innovación en Pesca y Acuicultura - PNIPA elaboro el presente documento. En este estudio se describirán los puntos necesarios para poder exportar paiche a Europa.
20
libro
Publicado 2018
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Con el objetivo de tener un manual sobre el mercado estadounidense de trucha de Perú, el Programa Nacional de Innovación en Pesca y Acuicultura - PNIPA elaboro el presente documento. En este estudio se describirán los puntos necesarios para poder exportar trucha a los Estados Unidos.
