Objective: Describe the association between asthma control and adherence to treatment in patients of the Hospital Nacional Dos de Mayo 2019-2020. Materials and methods: A quantitative, descriptive and retrospective clinical study was carried out during the 2019-2020 period in asthmatic patients from the Hospital Nacional Dos de Mayo (HNDM). The relationship between control and adherence to treatment in patients seen in the Asthma office of the Pneumology Service was evaluated by collecting data: Inhaler adherence test (TAI), Asthma control test (ACT) age, sex, treatment established, time of illness and nutritional assessment, through the review of medical records. Statistical analysis was performed with IBM SPSS Statistics version 22 software and the chi-square statistical test was performed to determine the association. Results: 187 patients were evaluated through medical records, 84 me...

Introduction: ALK tyrosine kinase inhibitors have exhibited promising activity against advanced ALK-rearranged NSCLC. However, co-occurring genetic alterations, such as CDKN2A/B or TP53, may negatively affect the efficacy of targeted therapies. Methods: From December 2017 to December 2022, this study cohort analyzed next-generation sequencing data of 116 patients with metastatic ALK-rearranged NSCLC from five Latin American cancer centers. Clinicopathologic and molecular features were associated with clinical outcomes and risk of brain metastasis (BrM) in patients with and without concurrent somatic alterations. Results: All patients (N = 116) received a second-generation ALK tyrosine kinase inhibitor, and alectinib was selected in 87.2% of cases. Coalterations occurred in 62% of the cases; the most frequent were TP53 mutations (27%) and CDKN2A/B loss (18%). The loss of CDKN2A/B was asso...