Resultados de Búsqueda por Autor

artículo

Characteristics and outcomes of thymomas in Latin America: Results from over 10 years of experience (CLICaP-LATimus)

Publicado por
Martín, C, Enrico, D, Mas Lopez, Luis, Patane, AK, Arrieta, O, Soria, T, Cardona, AF, Ruiz-Patiño, A, Ruiz, R, Rioja, P, Lozano, S, Zatarain-Barrón, ZL, Barrón, F, Puparelli, C, Tsou, F, Corassa, MP, Freitas, HC, Cordeiro de Lima, VC, Rojas, L, Ordóñez-Reyes, C, Corrales, L, Sotelo, C, Rodríguez, J, Ricaurte, L, Ávila, J, Archila, P, Rosell, R, Cuello, M, Remon, J

Publicado 2021

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Background: Thymomas are a group of rare neoplasms of the anterior mediastinum. The objective of this study was to describe the demographics, clinical characteristics and treatment approaches in Latin America.Methods: This was a retrospective multicenter cohort study including patients with histologically proven thymomas diagnosed between 1997 and 2018. Demographics, clinicopathological characteristics and therapeutic outcomes were collected locally and analyzed in a centralized manner. Results: A total of 135 patients were included. Median age at diagnosis was 53 years old (19-84), 53.3% (n = 72) of patients were female and 87.4% had an ECOG performance score ranging from 0-1. A total of 47 patients (34.8%) had metastatic disease at diagnosis. Concurrent myasthenia gravis occurred in 21.5% of patients. Surgery was performed in 74 patients (54.8%), comprising 27 (20%) tumorectomies and 4...

artículo

STK11 and KEAP1 mutations in non-small cell lung cancer patients: Descriptive analysis and prognostic value among Hispanics (STRIKE registry-CLICaP)

Publicado por
Cordeiro de Lima, VC, Corassa, M, Saldanha, E, Freitas, H, Arrieta, O, Raez, L, Samtani, S, Ramos, M, Rojas, C, Burotto, M, Chamorro, DF, Recondo, G, Ruiz-Patiño, A, Más López, L, Zatarain-Barrón, L, Mejía, S, Nicolas Minata, J, Martín, C, Bautista Blaquier, J, Motta Guerrero, R, Aliaga-Macha, C, Carracedo-Gonzales, C, Ordóñez-Reyes, C, Garcia-Robledo, JE, Corrales, L, Sotelo, C, Ricaurte, L, Santoyo, N, Cuello, M, Jaller, E, Rodríguez, J, Archila, P, Bermudez, M, Gamez, T, Russo, A, Viola, L, Malapelle, U, de Miguel Perez, D, Rolfo, C, Rosell, R, Cardona, AF

Publicado 2022

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Background: Mutations in STK11 (STK11Mut) and, frequently co-occurring, KEAP1 mutations (KEAP1Mut) are associated with poor survival in metastatic Non-small Cell Lung Cancer (mNSCLC) patients treated with immunotherapy. However, there are limited data regarding the prognostic or predictive significance of these genomic alterations among Hispanics. Methods: This retrospective study analyzed a cohort of Hispanic patients (N = 103) diagnosed with mNSCLC from the US and seven Latin American countries (LATAM) treated with immune checkpoint inhibitors (ICI) alone or in combination as first-line (Cohort A). All cases were treated in routine care between January 2016 and December 2021. The main objectives were to determine the association of mutations in STK11 or KEAP1 in these patients’ tumors with overall (OS) and progression-free survival (PFS), presence of KRAS mutations, tumor mutational ...