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artículo
Publicado 2021
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The current Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic has severely impacted the economy and health care system in more than 180 countries around the world in an unprecedented event, which since its inception has resulted in countless case reports focusing on the potentially fatal systemic and respiratory manifestations of the disease. However, the full extent of possible neurological manifestations caused by this new virus is not yet known. Understanding the interaction of SARS-CoV-2 with the nervous system is essential to assessing likely short- and long-term pathologic consequences. This review seeks to gather and discuss evidence on the occurrence of neurological manifestations and/or nervous system involvement in SARS- CoV-2 infected patients.
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artículo
Publicado 2021
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Several scientific articles have proposed hypotheses to associate the disease caused by the SARS-CoV-2 virus with periodontitis. Delving into the possible risk factors and indicators are essential elements to understand the role of the virus in the pathogenesis of periodontitis; they indicate the need for a joint work of physician and periodontologists in the protocol for the prevention and control of COVID-19. The relationship between these diseases is considered to be bidirectional, the effect of the virus on the immune system can aggravate periodontitis and, on the other hand, the effects of chemical mediators of periodontitis can make the patient more vulnerable once infected by SARS-CoV -2 to develop a co-infection. Key words: COVID-19 - periodontitis - SARS-CoV-2 - virus
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artículo
Publicado 2021
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Several scientific articles have proposed hypotheses to associate the disease caused by the SARS-CoV-2 virus with periodontitis. Delving into the possible risk factors and indicators are essential elements to understand the role of the virus in the pathogenesis of periodontitis; they indicate the need for a joint work of physician and periodontologists in the protocol for the prevention and control of COVID-19. The relationship between these diseases is considered to be bidirectional, the effect of the virus on the immune system can aggravate periodontitis and, on the other hand, the effects of chemical mediators of periodontitis can make the patient more vulnerable once infected by SARS-CoV -2 to develop a co-infection. Key words: COVID-19 - periodontitis - SARS-CoV-2 - virus
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artículo
Publicado 2021
Enlace
Enlace
The current Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic has severely impacted the economy and health care system in more than 180 countries around the world in an unprecedented event, which since its inception has resulted in countless case reports focusing on the potentially fatal systemic and respiratory manifestations of the disease. However, the full extent of possible neurological manifestations caused by this new virus is not yet known. Understanding the interaction of SARS-CoV-2 with the nervous system is essential to assessing likely short- and long-term pathologic consequences. This review seeks to gather and discuss evidence on the occurrence of neurological manifestations and/or nervous system involvement in SARS- CoV-2 infected patients.
6
artículo
Publicado 2021
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Introduction: Genomic analysis of samples from documented COVID-19 cases can be used successfully to help track sources of Sars-Cov-2 infection, which can be quarantined to prevent the recurrent spread of the disease around the world. Objective: To describe the SARS-CoV-2 sequences isolated from Peruvian patients. Methods: All genomes published up to March 2021, uploaded in the GISAID and Nextstrain repository, were selected. All data is on the web in a public way; In addition, the information was filtered by continent, country, region, clade, lineage, and sex from March 2020 to February 2021. Results: It was evidenced that the region with the most isolated genomes was Lima, the most frequent clade is GR, the viral lineage B.1.1 is the most frequent and persistent in time and most of the genomes were isolated from people of the female sex.Conclusions:&n...
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artículo
Publicado 2022
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In SARS-CoV-2 virus infection, HIF-1 overexpression drives a glycolysis-dependent metabolic change for increased cell proliferation and cytokine synthesis in various cells and tissues; Furthermore, due to the insufficient amount of ATP, various metabolic pathways that induce hyperglycemia are accelerated; an indicator of poor prognosis and high mortality in patients without a previous diagnosis of diabetes. Hyperglycemia is the result of oxidative stress-induced insulin resistance and increased glycolysis, as well as dysregulation of hormones such as glucagon, growth hormone, glucocorticoids, and insulin; whose synthesis decreases due to the transdifferentiation of beta cells. These hyperglycemic and hypoglycemic conditions have been associated, in COVID-19 patients, with new-onset diabetes, cardiomyocyte damage, and other cardiac problems with lung deterioration; as well as the presence...
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artículo
Objective: To describe the prevalence and characteristics of seropositive pregnant women for SARS-CoV-2. Material and methods: Quantitative, cross-sectional and descriptive study. Performed in pregnant women screened for SARS-CoV-2 who met selection criteria at hospital admission. Variables of maternal characteristics, pregnancy complications and newborn condition were collected from the respective medical history. Data analysis was performed using descriptive statistics and 95% confidence intervals. Results: 1477 pregnant women admitted to hospitalization were screened, identifying a seroprevalence of anti-SARS-CoV-2 antibodies in 5.28% (95% CI: 4.22% -6.57%). Among the cases of positive seroprevalence, IgM 11.5% (95% CI: 5.7% -21.3%), IgM / IgG 64.1% (95% CI: 5.7% -21.3%), IgG 19% (95% CI: 15.7% and 35.6) were observed %), 91% of seropositive pregnant women were asymptomatic, 40% of se...
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artículo
Objective: To describe the prevalence and characteristics of seropositive pregnant women for SARS-CoV-2. Material and methods: Quantitative, cross-sectional and descriptive study. Performed in pregnant women screened for SARS-CoV-2 who met selection criteria at hospital admission. Variables of maternal characteristics, pregnancy complications and newborn condition were collected from the respective medical history. Data analysis was performed using descriptive statistics and 95% confidence intervals. Results: 1477 pregnant women admitted to hospitalization were screened, identifying a seroprevalence of anti-SARS-CoV-2 antibodies in 5.28% (95% CI: 4.22% -6.57%). Among the cases of positive seroprevalence, IgM 11.5% (95% CI: 5.7% -21.3%), IgM / IgG 64.1% (95% CI: 5.7% -21.3%), IgG 19% (95% CI: 15.7% and 35.6) were observed %), 91% of seropositive pregnant women were asymptomatic, 40% of se...
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artículo
Publicado 2021
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Background: The genetic variability of SARS-CoV-2 has increased notably since the pandemic was declared, which has allowed it to represent a continuous challenge for health policies aimed at its control. Objective. Describe the genomic nomenclature used for general and scientific communication about SARS-CoV-2, as well as describe the mutations, evolution, origin and variants of the virus. Material and Methods. A narrative literature review was carried out, for which a search and analysis of the information was carried out until December 15, 2021. 74 sources selected from the MEDLINE / PubMed, SciELO, LILACS databases and official web pages were reviewed; no language restrictions. Results. Mutations are changes in the nucleotide sequence of the viral genome, which, by affecting the epidemiological dynamics in a population, give rise to variants, and these in turn to differentiated clades...
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artículo
Publicado 2021
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The global spread and lethality of SARS-CoV-2 prompt the urgent need to develop an appropriate therapeutic strategy to control COVID-19 cases. The development of new drugs to fight this novel virus is urgent due to its rapid spread. Parallel alternatives have been proposed by using drugs already available for similar purposes. This review article describes theantiviral potential of ivermectin as well as its mechanisms of action against some viruses, and discusses its probable use to fight SARS-CoV-2.
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artículo
Publicado 2022
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Patients with eating disorder (ED) are a vulnerable population in the context of the COVID-19 pandemic. Some studies describe its negative effect on ED patients and their caregivers. This article presents a narrative review of the impact of the SARS-CoV-2 pandemic on these patients. Depressive and anxious symptoms, risk of self-harm and suicide are identified. Early intervention and management of patients with ED is a great challenge to the continuity of treatment, detection of comorbidities and relapse prevention.
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artículo
A 36-year-old male with a history of moderate SARS-CoV-2 pneumonia three months earlier presented nephrotic syndrome with compromised renal function, where the histopathological diagnosis was compatible with collapsing glomerulopathy and, in electron microscopy of renal tissue, tested positive for the antibody against the nucleocapsid of SARS-COV-2 MA5-35943. Refractory to treatment with prednisone, remission of proteinuria was achieved when treated with tacrolimus. It is emphasized that SARS-CoV-2 infection can generate renal involvement by different pathological mechanisms.
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revisión
El objetivo es describir la evidencia científica disponible sobre la precisión diagnóstica de las pruebas rápidas de detección de antígenos para SARS-CoV-2.
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artículo
Publicado 2020
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Humankind is currently facing a challenge that distinguishes no borders, ideologies, socioeconomic systems, ethnic groups, religions or cultures. It is a war that unites us as a biological species, in which the main weapons come from research aimed at improving health systems. In this war, governments and international health organizations define the strategy; and health systems and law enforcement agencies, together with citizens’ support, carry out actions and fight the battles. However, the most important battle is fought inside each of us. Just like Perseus fought against Hades in a battle of titans to prevent the Earth from turning into hell, the immune system activates a powerful machinery in which molecules and cells of the innate and acquired immune system jointly act to defeat SARS-Cov-2: a machinery that follows a script written by evolution, and that will leave in our immune...
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artículo
Currently, both in Peru and in other countries, we have a wide range of tests available for the identification of individuals infected with COVID-19 disease; however, do we know the advantages and limitations of each of them?
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artículo
Publicado 2020
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En diciembre del 2019, una enfermedad respiratoria denominada COVID19 apareció en la ciudad de Wuhan, China, y se expandió a nivel global. Dicha enfermedad es causada por el coronavirus SARS-CoV-2, y constituye la mayor amenaza a la salud pública dentro de las ultimas décadas. Actualmente, es vital estudiar dicha enfermedad a nivel multidisciplinario para encontrar tratamientos efectivos, así como para comprender su desarrollo e impacto dentro de la historia humana. Este artículo de revisión se centra en recapitular la información que se conoce hasta la fecha sobre este virus, su origen, características y las estrategias que diversos gobiernos han adoptado en los últimos meses.Palabras claves: COVID19, coronavirus, SARS-CoV, SARS-CoV2. ABSTRACTIn December 2019, a respiratory disease named COVID19 emerged in the city of Wuhan, China, and it spread around the globe. This disease...
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artículo
Publicado 2020
Enlace
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En diciembre del 2019, una enfermedad respiratoria denominada COVID19 apareció en la ciudad de Wuhan, China, y se expandió a nivel global. Dicha enfermedad es causada por el coronavirus SARS-CoV-2, y constituye la mayor amenaza a la salud pública dentro de las ultimas décadas. Actualmente, es vital estudiar dicha enfermedad a nivel multidisciplinario para encontrar tratamientos efectivos, así como para comprender su desarrollo e impacto dentro de la historia humana. Este artículo de revisión se centra en recapitular la información que se conoce hasta la fecha sobre este virus, su origen, características y las estrategias que diversos gobiernos han adoptado en los últimos meses.Palabras claves: COVID19, coronavirus, SARS-CoV, SARS-CoV2. ABSTRACTIn December 2019, a respiratory disease named COVID19 emerged in the city of Wuhan, China, and it spread around the globe. This disease...
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artículo
Background: Public health policies for decreasing the incidence, transmission, and mortality of COVID-19 focus on extradomiciliary measures and neglect transmission within the home. We aimed to estimate the rate of secondary home attack of SARS-CoV-2. Material and Methods: We conducted a systematic review of observational studies that evaluated home transmission of SARS-CoV-2 published between December 2019 and September 1, 2021 in Medline, Scopus, LILACS, and Google Scholar databases. The definition of household contact referred to any person living in the same house as the index patient. The risk of bias was assessed with a modified version of the Newcastle-Ottawa tool. A meta-analysis was performed with a random-effects model to calculate the household attack rate, subanalysis with sociodemographic, epidemiological variables, and comorbidities, as well as meta-regression. Results: O...
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artículo
Background:The COVID-19 pandemic has had a big impact around the world and as obesity is an important risk factor for the severe form of the SARS-CoV-2 disease, bariatric surgery will have a great clinical impact. Performing this surgery in people with obesity implies weight loss, which has multiple beneficial effects such as reducing the inflammatoryresponse,increasingimmunityandimproving cardiopulmonary and kidney function. This review is intended to provide updated information on bariatric surgery in the morbidity and mortality of SARS-CoV-2 infection. Expecting that it provides support tothereaderinordertounderstandthepathophysiological mechanisms involved in the better prognosis and lower probability of hospitalization and mortality from COVID-19, pending comparison of obese patients who have not undergone bariatric surgery
