Tópicos Sugeridos dentro de su búsqueda.
https://purl.org/pe-repo/ocde/ford#2.00.00 4 Control predictivo 3 20th century 2 Alianza del Pacífico 2 América Latina 2 Aprendizaje automático (Inteligencia artificial) 2 Arsénico--Perú--Andes, Región 2 más ...
Mostrando 1 - 20 Resultados de 56 Para Buscar 'para novel complex', tiempo de consulta: 0.79s Limitar resultados
1
artículo
Este artículo de carácter empírico e interpretativo tiene como objetivo ofrecer un aporte a la discusión de los Semilleros como espacios investigativos en la formación del investigador novel. Es producto de reflexiones realizadas por los autores sobre la temática y de las discusiones realizadas con jóvenes de pregrado y postgrado que aspiran ser investigadores en el campo de la educación. Se sustenta en un marco referencial relacionado con: a) la investigación como Proceso sistemático que se aprende y enseña y; b) Competencias en Investigación para la formación de los investigadores noveles. Parte del supuesto que investigar en el ámbito de las ciencias de la educación es complejo, sin embargo, ello las hace fértiles y un semillero para obtener competencias investigativas. Se concluye con la propuesta de tres acciones o caminos relacionados con la formación de investigad...
3
tesis doctoral
Plants have an innate immune system that is organized at two levels: one on the surface of the cells and another in the cytoplasm of the cell. Receptors on the cell surface are involved in the first line of defense, triggering immune responses by perceiving immunogenic patterns that occur during pathogen invasion. The Cf-4 receptor, present on the cell surface of tomato, requires the presence of the co-receptor SOBIR1 to confer resistance to strains of the fungal pathogen Cladosporium fulvum that secrete the Avr4 effector protein. This interaction triggers an immune response that includes a form of programmed cell death known as the hypersensitive response (HR). This thesis explores the early signaling events triggered by the cell surface receptor Cf-4, using the solanaceous model plant Nicotiana benthamiana. Furthermore, a novel method to visualize and quantify HR intensity is presented...
4
tesis de maestría
Develops the design of a new contemporary art museum, through the innovation of a new architectural design methodology aided by new computational techniques. Based on the structural capacity and geometric organization in the textile units, we speculate about a new way of conceiving spatiality and geometry helped by new computational techniques. Geometric units are digitally reproduced and a series of parameters from the architectural program are formulated. These performative mechanisms or models generate complex geometry based on the spatial needs of the building. The collection of results is analyzed and classified to generate geometry and architectural spatiality capable of containing a specific activity and area of the museum. The project conceptualizes the mathematical and inverse parity effect for the planning of the new contemporary art museum in the city of Frankfurt am Main.
5
artículo
The classification of “The Silent War” series (1970-1979) as “pro-indigenous literature” led to the epic nature of Manuel Scorza’s novels being overlooked, together with the complexity and richness of a literature that employs both the narrative device of the chronicle and the path opened by the new novel to explore the disconnects between myth and history. The “Immobile Dance” (1983), the first of a new series of novels entitled “The Fire and the Ash”, would continue to employ the epic form and the new forms of writing, inviting critical reflection on how Latin American literature is received in Europe.
6
artículo
El artículo busca hacer una valoración de Rupito, novela escrita por el sacerdote ecuatoriano Leonidas Proaño, en el marco de la corriente conocida como teología de la liberación. Escrita originalmente en 1953, Rupito antecede a la emergencia continental de esta corriente teológica que marcó el pensamiento y la acción de una facción progresista de la Iglesia católica latinoamericana a partir de la década de 1960. No obstante, en su propuesta pueden reconocerse ya algunos de los elementos fundamentales que hicieran significativo el aporte de Proaño a esa postura regional, por lo que es válido acercarse a ella desde esa perspectiva para abrir la posibilidad de una interpretación de la obra —poco reconocida en el marco de la novelística ecuatoriana— en una dimensión más abierta y compleja. Para realizar la lectura propuesta, se vincula tanto la labor pastoral como la po...
7
artículo
The purpose of this article is to reflect on the implications of recognizing the intrinsic value of life in forests and, to this end, it proposes a forestry vision beyond timber; it takes as a reference the contributions of the Colombian philosopher Carlos Maldonado and complements them with the contributions of the process "Towards a new Forestry Policy for Peru" in which the author acted as a systematiser. It is found that the denomination of forest resources obeys an economicist con­ception sustained by a disjunctive form of human relationship with forests. The currents of nature conservation indicate that there is a biocentric turn that overcomes the anthropocentric ethic that has prevailed to date. Hence the need to broaden the forest concept reduced to timber. From the reflection it is concluded that the incorporation of an expanded vision of forest sciences includes the recogniti...
8
artículo
Heart failure with reduced ejection fraction (HFrEF) and nonalcoholic fatty liver disease (NAFLD) are two common comorbidities that share similar pathophysiological mechanisms. There is a growing interest in the potential of targeted therapies to improve outcomes in patients with coexisting HFrEF and NAFLD. This manuscript reviews current and potential therapies for patients with coexisting HFrEF and NAFLD. Pharmacological therapies, including angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, mineralocorticoids receptor antagonist, and sodium-glucose cotransporter-2 inhibitors, have been shown to reduce fibrosis and fat deposits in the liver. However, there are currently no data showing the beneficial effects of sacubitril/valsartan, ivabradine, hydralazine, isosorbide nitrates, digoxin, or beta blockers on NAFLD in patients with HFrEF. This study highlights the imp...
9
tesis de grado
El presente trabajo de investigación realizó un análisis cualitativo de tres novelas gráficas periodísticas que cubren historias de temáticas sensibles y problemáticas sociales. Se ha tomado en consideración obras que reconocidas por su valor periodístico en la industria. El propósito de este trabajo es demostrar que la novela gráfica es un género de gran provecho en el abordaje en profundidad de historias de manera creativa; de esta manera, más periodistas en nuestro país e internacionalmente se animarán en el futuro a explorar este formato. De la misma manera, se busca promover la investigación académica sobre el género y su enseñanza en las escuelas superiores de periodismo. El trabajo recogió investigaciones anteriores relacionados al tema y reunió una lista de elementos que cumplen las novelas gráficas para demostrar su valor periodístico como el trabajo de ca...
10
tesis de maestría
En el diagnóstico de la enfermedad de Alzheimer con tomografía por emisión de positrones (PET), la principal problemática radica en el uso de radioisótopos tradicionales (18F, 11C) los cuales limitan el correcto desempeño de los agentes de imagen PET sobre las placas Aβ-amiloides. El [11C]-PIB, el [18F]-florbetapir y el [18F]-florbetaben representan algunos ejemplos de lo mencionado. Actualmente, los complejos quelatos de radioisótopos de metales de transición prometen ser una tentadora y potencial solución para tal problemática. De este grupo destacan los quelatos radiomarcados con 64Cu y compatibles con las placas Aβ. Sin embargo, la gran mayoría de estos casos todavía no son del todo exitosos. Por esta razón, y en base a las nuevas necesidades, se propone un nuevo complejo de cobre(II) basado en un ligando con grupos afines a las placas Aβ-amiloides cuya formación inv...
11
tesis de maestría
En el diagnóstico de la enfermedad de Alzheimer con tomografía por emisión de positrones (PET), la principal problemática radica en el uso de radioisótopos tradicionales (18F, 11C) los cuales limitan el correcto desempeño de los agentes de imagen PET sobre las placas Aβ-amiloides. El [11C]-PIB, el [18F]-florbetapir y el [18F]-florbetaben representan algunos ejemplos de lo mencionado. Actualmente, los complejos quelatos de radioisótopos de metales de transición prometen ser una tentadora y potencial solución para tal problemática. De este grupo destacan los quelatos radiomarcados con 64Cu y compatibles con las placas Aβ. Sin embargo, la gran mayoría de estos casos todavía no son del todo exitosos. Por esta razón, y en base a las nuevas necesidades, se propone un nuevo complejo de cobre(II) basado en un ligando con grupos afines a las placas Aβ-amiloides cuya formación inv...
12
artículo
En este artículo pretendo revelar la profunda base antropológica de la novela afroperuana Okelo, un niño esclavizado (Lima, 2021) de León Zamora, que da cuenta del complejo proceso sociocultural y psicológico del fenómeno de la esclavización en el Perú. Principalmente, destaco cómo el autor levanta una serie de cuestiones relevantes del fenómeno histórico de la esclavización africana en nuestro país que no han sido abordadas, de manera suficiente, desde una perspectiva antropológica y decolonizadora, tales como la visión tribal y colonialista de África, el impacto de la diversidad étnica de la población esclava en la construcción de una nueva identidad, la herencia cultural africana, los procesos de choque intercultural experimentados en América, el procesamiento del trauma de la esclavización, etc. Por último, hago una valoración positiva de la novela como un espa...
13
artículo
César Vallejo is one of the most representative figures of Peruvian literature and his works have been approached from different perspectives that have been debated until today. Thus, the novel Fabla salvaje, despite its short length, is a complex text that has been read mainly as a representation of identity conflict, dementia or masculinity. In view of this predominance, we consider that an approach to the female character in the novel is necessary in order to generate a reading that dialogues with other aesthetic proposals close to the work. In this sense, the present work will dialogue with the nineteenth­century cliché of the «angel of the home», which is present in pictorial and literary art and which constitutes a stereotype of the role of women in society. The aim is to recognise the differences and similarities in the conformation of this cliché in Adelaide and Lucia, char...
14
artículo
This article offers an analysis of the classic motif of me­mory; we will study the use of ekphrasis as a testimony of memory, as expressed in the images contained in the ponchos; we will consider Andean notions of time and its place in myth, and discuss how in the text —as well as in the ponchos— we find an end that marks a beginning, and a beginning that marks an end. The article analyzes the process of constructing ekphrasis through the narrative voice and the use of sub-motifs related to the central motif of memory: knowledge, the world turned upside down, eternal return, oblivion, and the complex dimensions of time, where the past, present and future are combined. We will employ comparative critical theory, specifically those notions expressed by imagology and thematology. The role played by memory as a fundamental motif in shaping our humanity is compared to the Andean mythical...
15
artículo
The goal of this study is to better understand the complexity of the canonical Wnt/β-catenin (C-WNT) signaling pathway in colorectal cancer (CRC): how it works, its key mutations and the novel therapeutic compounds under development. PubMed, Scopus and SciELO were used to find the most relevant medical literature on the issue. The C-WNT signaling pathway regulates essential cellular biological processes: genetic changes in this pathway are significant contributors to CRC. The Wnt ligand binding to the Frizzled receptor and low-density lipoprotein receptor-related protein 5 or 6 (LRP5/6) stimulates the C-WNT signaling pathway; this extracellular membrane ternary complex activates kinases that promote phosphorylation of the intracellular domain of LRP5/6 and starts the cell signaling cascade. The C-WNT signaling pathway is changed in more than 90 % of all CRCs, with the adenomatous polypo...
16
artículo
Substantial material, financial and human resources are dedicated to research on tumor biology. The validation of biomarkers, the development of novel diagnostic methods, the implementation of early detection programs in communities, and the promotion of healthy lifestyles have positively impacted on the prevention and control of this group of diseases. However, cancer remains a global health problem. Multiple factors affect the effective management of neoplasia, including the complex relationship between immune system and transformed cells. It is a fact that the diversity of immune system´s effector mechanisms detect and eliminate neoplastic cells. However, these immune mechanisms also promote somatic evolution of tumors by selecting cellular clones resistant to immunity. This complex relationship conceptualized as cancer immunoediting develops mainly at the tumor microenvironment. Imm...
17
artículo
The main objective of the study was to apply the triadic method of Gérard Genette (1989), to analyze the narrative structure of the novel Tomorrow I will return. For this purpose, we started from the principle that every literary creation has two components: the story, represented by the what or level of meaning; and the discourse, the how or plane of the signifier. These components were analyzed taking into account the contributions of narratology and, assuming as a method of study, the three categories proposed by Genette: modalization, temporalization and spatialization. The results showed that the global corpus of the narrative has been built taking into account multiple points of view, called focalizations, added to distortions of time and the configuration of an extended socio-cultural space. This reality is heterogeneous, complex and contradictory, in which it coexists, especiall...
18
artículo
Based on case studies in Mexico, Chile and Peru, researchers from anthropology, sociology, education and psychology, provide novel material and analytical approaches to understand the complex redefinitions, resistances and permanence that men in urban societies in Latin American  experiment in their masculine identities.
19
revisión
A partir de estudios de caso en México, Chile y el Perú, investigadores provenientes de la antropología, la sociología, la educación y la psicología, proporcionan novedoso material y enfoques de análisis para comprender las complejas redefiniciones, resistencias y permanencias que varones de sociedades urbanas latinoamericanas experimentan en sus identidades masculinas.
20
artículo
According to reports from the Observatorio Nacional de Crímenes de Odio contra Personas LGBT, violence towards this community has reached alarming levels in recent years. This problem has reached fiction: Fernanda Melchor addresses this topic in her novel Temporada de huracanes (2017), where the proliferation of hate crimes becomes the central theme. This article carries out a critical study on masculinity and the queer subject, analyzing how the latter influences heterocentric behavior, revealing fissures and alternative identities concealed beneath hypermasculinity. Through a meticulous analysis of the behavior of the main characters, this work scrutinizes the silences, dissonances, and behaviors that unbalance hegemonic masculinity and at the same time, explores how homophobia is used as a tool to maintain social control, which reveals a complex social problem that queer subjects suf...