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1
artículo
The central granular cell odontogenic tumor (CGCOT) is a rarely seen neoplasm of odontogenic origin with a predilection for mandible of middle aged women. The lesion shows slow growing and radiographic feature of a radiolucent unilocular lesion with a radiopaque border. The present study aims to report a new case of CGCOT with an atypical involvement of anterior maxilla. Clinical exam showed swelling of the hard palate and the vestibular area of left canine and pre-molar of maxilla. Cone beam computed tomography showed a hypodense unilocular well delimited lesion extending from central left incisive to left pre-molar region. Histopathological analysis showed granular eosinophilic cells and islands of odontogenic epithelium and positive immunostaining for CK14, vimentin, CD68, Ki67 and S-100, which established the diagnosis of CGCOT. The patient is under follow-up without recurrence for s...
2
artículo
Publicado 2021
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Central giant cell granuloma (CGCG) is a benign intraosseous lesion of the jaws. Traditionally, surgery is the most used treatment for this type of pathology, however, in recent years the use of intralesional corticosteroids injections has been proposed as a conservative alternative. The aim of this study is to carry out a bibliographic review of the cases treated with corticosteroids. The author used PubMed and Google Scholar platforms were used to search for articles published between 1994 and 2020, related to CGCG and its treatment with corticosteroids. The results of this research were 28 articles and one abstract were found with 61 patients in total; in most cases, weekly intralesional injections of triamcinolone acetonide with anesthetic were used for 6 weeks, although protocol variants were reported. Of the 61 cases, 38 had complete resolution while the other cases required additi...
3
artículo
Publicado 2021
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El granuloma central de células gigantes (GCCG) es una lesión benigna intraósea de los maxilares. Tradicionalmente, la cirugía es el tratamiento más utilizado para este tipo de patología, sin embargo, en los últimos años se ha propuesto el uso de inyecciones intralesionales de corticoesteroides como alternativa conservadora. El objetivo de este estudio fue realizar una revisión bibliográfica de los casos tratados con corticoesteroides. Para esto, se utilizó la plataforma de PubMed y Google Scholar para buscar artículos publicados entre 1994 y el 2020, relacionados al GCCG y su tratamiento con corticoesteroides. Se encontraron 28 artículos y un resumen con 61 pacientes en total; en la mayoría de los casos se utilizaron inyecciones intralesionales semanales de acetonido de triamcinolona con anestésico durante 6 semanas, aunque se reportaron variantes del protocolo. De los 61...
4
artículo
Publicado 2020
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Non-Hodgkin lymphomas make up a group of malignant neoplasms of lymphoid origin, according to their corresponding cell line, as B or T cell lymphomas classified. Mostly, these entities come from B lymphocytes, being the most frequent diffuse large B-cell lymphoma (DLBCL). In the oral cavity, non-Hodgkin lymphomas have low incidence and their prognosis, clinical evolution and response to treatments, depend on the subtype presented. These malignancies can develop in soft tissues of the oral cavity or centrally in the jaws. We report an 80-year-old patient with an injury corresponding to large B-cell non-Hodgkin lymphoma in the oral cavity, who has been treated with chemotherapy and radiotherapy, responding favorably to treatment. Likewise, in order to describe this infrequent type of lesions of the oral cavity and to assess the prognosis they have, a literature review was performed. It is ...
5
artículo
Publicado 2020
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Non-Hodgkin lymphomas make up a group of malignant neoplasms of lymphoid origin, according to their corresponding cell line, as B or T cell lymphomas classified. Mostly, these entities come from B lymphocytes, being the most frequent diffuse large B-cell lymphoma (DLBCL). In the oral cavity, non-Hodgkin lymphomas have low incidence and their prognosis, clinical evolution and response to treatments, depend on the subtype presented. These malignancies can develop in soft tissues of the oral cavity or centrally in the jaws. We report an 80-year-old patient with an injury corresponding to large B-cell non-Hodgkin lymphoma in the oral cavity, who has been treated with chemotherapy and radiotherapy, responding favorably to treatment. Likewise, in order to describe this infrequent type of lesions of the oral cavity and to assess the prognosis they have, a literature review was performed. It is ...
6
tesis de maestría
Publicado 2014
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Se estudió el potencial de producción de ácidos grasos de dos cepas de M. alpina (CBS 210.32 y CBS 528.72), seleccionando la cepa CBS 528.72 debido a su mayor rendimiento de producción. Así como también se desarrolló un método de inoculación óptimo basado en una suspensión celular. La optimización de un medio de cultivo fue realizada mediante diseño experimental, estudiando la influencia de fuentes de carbono, fuentes de nitrógeno y parámetros de fermentación. Dicho diseño experimental fue realizado en dos pasos: primero, se evaluó la influencia de nueve macro/micro elementos en un rango cuidadosamente elegido, usando un diseño de Plackett- Burman y segundo, se aplicó un diseño compuesto central rotable para la optimización de los niveles propuestos. Después del proceso de optimización, se alcanzaron 23.49 g/L de biomasa fúngica seca y 47.32% de lípidos. Posteri...
7
artículo
Primary central nervous system lymphoma (PCNSL) constitutes 2% of extranodal lymphomas and 0,3%-1,5% of all intracranial neoplasms in immunocompetent patients, being more frequent after the sixth decade of life. We report a case of a 76 year-old man with no antecedents who started his disease with march instability, difficulty to move left side of his body with brachial predominance, holocraneal headache and dizziness. He arrived at emergency with Glasgow 14 and right eyelid ptosis. He had left sided hemiparesis and hypoesthesia with crural predominance and occasional disorientation. Brain computed tomography (CT) showed a contrastenhanced image in the right frontoparietal region with both extra- and intra-cranial components, cerebral edema and middle line deviation. Craniotomy and biopsy of the tumor resulted in diffuse large B cell lymphoma of the central nervous system. The patient wa...
8
artículo
Publicado 2023
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Background: Actinomycosis is an unusual chronic bacterial infection, even rarer in people living with HIV. It is not considered an AIDS-defining disease. However, the role in co-presentation or overlap with other opportunistic conditions of advanced HIV is unknown. Case presentation: A 49-year-old Peruvian male presented with a 4-month history of dysphagia, odynophagia, hyporexia and wasting. He underwent an upper digestive endoscopy, in which ulcers with a necrotic center were observed, therefore, the initial diagnostic assumption was esophageal cancer. Subsequent pathology report excluded neoplasms and confirmed the diagnosis of actinomycosis. Serology for human immunodeficiency virus was requested, yielding a positive result. Antimicrobial treatment with amoxicillin and antiretroviral therapy were indicated, with slow clinical improvement. After 4 months, epigastric discomfort present...
9
artículo
Since 1978, clinical uses within the central nervous system have been found for omentum tissue, particularly in patients with ischemic conditions and/or ischemic penumbra. Omental tissue, one form of white adipose tissue (WAT), has some features that distinguish it from other WAT depots in other areas of the body. It is the best adipose tissue for developing vascular connections with surrounding tissue, and through these newly formed arterial blood vessels, nervous parenchyma may receive nutrients, oxygen, neurotransmitters, neurotrophic factors and stem cells. Moreover, the amount of adherent scar tissue in the omentalnervous system interface is minimal.
10
artículo
Since 1978, clinical uses within the central nervous system have been found for omentum tissue, particularly in patients with ischemic conditions and/or ischemic penumbra. Omental tissue, one form of white adipose tissue (WAT), has some features that distinguish it from other WAT depots in other areas of the body. It is the best adipose tissue for developing vascular connections with surrounding tissue, and through these newly formed arterial blood vessels, nervous parenchyma may receive nutrients, oxygen, neurotransmitters, neurotrophic factors and stem cells. Moreover, the amount of adherent scar tissue in the omentalnervous system interface is minimal.
11
artículo
Publicado 2023
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The case of a 20-year-old male patient is presented, with an illness of one week characterized by asthenia, hyporexia, nausea, vomiting, neck stiffness, intermittent headache of intensity 9/10, fever quantified at 38.5. °C, scant dry cough, weight loss and left hemiparesis without loss of consciousness. Serological tests, including HIV, were negative. The spinal fluid showed pleocytosis with a predominance of mononuclear cells, hyperproteinorrachia and hypoglycorrhachia, with a positive GeneXpert MTB/RIF test for M. tuberculosis resistant to rifampicin, in addition to a positive sputum smear for the same germ. The images showed a miliary pattern and vascular compromise (bilateral hypodensities at the level of the basal ganglia and internal capsule). He was treated as multidrug-resistant systemic tuberculosis with a favorable outcome.
12
artículo
Publicado 2021
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Ten nests of Sceliphron fistularium were obtained in two sites: Panama Oeste province, shores of Gatun Lake, Jungle Land Panama, and the province of Panama in the building of the School of Biology, University of Panama, Central Campus. The complete nests consisted of 3 to 14 cells, making a total of approximately 79 cells among the 10 nests. The nests were tubular in shape with the upper end oval and the basal end with a slight decrease in acute form, arranged side by side along a horizontal axis, and were found attached to different artifacts: a telephone wire (Campus Central University of Panama, n = 2); in three plastic chairs and two in wooden ceiling beams, installations of a floating boat (Gatun Lake, Jungle Land Panama, chairs n = 5 and wood n = 3). The number of cells per nest ranged from 3 to 14, their length ranged from 32.5 to 38.6 mm and their diameter from 15.3 (anterior) to...
13
artículo
Publicado 2021
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Introduction: This article summarizes the clinical practice guidelines (CPG) for the management of patients with ALL in the Social Security of Peru (EsSalud). Objective: To provide clinical evidence-based recommendations for the evaluation and management of patients with ALL in EsSalud. Methods: A CPG for the diagnosis and management of patients with ALL in EsSalud was developed. To this end, a guideline development group (local GDG) was established, including medical specialists and methodologists. The local GDG formulated 8 clinical questions to be answered by this CPG. Systematic searches of systematic reviews and -when it was considered pertinent- primary studies were conducted in PubMed and CENTRAL during 2019. The evidence to answer each of the posed clinical questions was selected. The quality of the evidence was assessed using the Grading of Recommendations Assessment, Developmen...
14
artículo
Publicado 2025
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Introduction: This article summarizes the clinical practice guideline (CPG) for the treatment of acute lymphoblastic leukemia in pediatric patients. Objective: To provide health professionals with evidence-informed recommendations for the treatment of acute lymphoblastic leukemia in pediatric patients. Methods: A guideline development group (GDG) was formed, including medical specialists and methodologists, which formulated 7 clinical questions. Systematic searches for systematic reviews and –when considered pertinent– primary studies were conducted in PubMed, Central, and Lilacs during June-August 2024. Evidence was selected to answer each of the clinical questions posed. The certainty of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. In periodic work meetings, the GDG used the GRADE methodology to review t...
15
artículo
We have achieved the identification of Langerhans cells in human cornea epithelium cross sections, fixed in Zenker’s liquid and embedded in paraffin, according to streptavidin-biotin peroxidase immunohistochemical method, in order to demonstrate protein S-100 and muramidase (lisozime) presence in them.Langerhans cells were identified easily from the rest of epithelial cells because they were the only elements protein S-100+ and muramidase+, which were stained light brown and showed rounded outlines with one or two prolongations.Langerhans cells were numerous in the limbic zone and null in the central region.
16
artículo
Publicado 2025
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Autoimmune hemolytic anemia (AIHA) is a rare disease that complicates pre-transfusion tests due to the presence of autoantibodies interfering with conventional serological techniques. This increases the risk of alloimmunization and hinders the selection of compatible units, particularly in multi-transfused patients. This article reviews the use of molecular techniques, such as red blood cell genotyping, to improve transfusion safety in AIHA patients. Data sources such as PubMed, Cochrane, Medline, and Scielo were reviewed to identify relevant studies published between 2013 and 2024. Molecular techniques provide faster and more precise typing, overcoming serological interferences, but face challenges like high costs and limited infrastructure in countries like Peru. The centralization of molecular immunohematology laboratories is proposed as a cost effective solution to ensure equitable a...
17
Publicado 2020
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Este artículo resume la Guía de práctica clínica para el diagnóstico y manejo de la infección por Helicobacter pylori en enfermedades gastroduodenales. Para realizar esta GPC se formó un grupo de trabajo de guías (GTF) con médicos especialistas y metodólogos, el grupo propuso 7 preguntas clínicas para ser respondidas en esta Guía de práctica clínica (GPC). Para responder a cada pregunta, se realizaron búsquedas sistemáticas de revisiones preliminares de PubMed y Central durante diciembre de 2019 y marzo de 2020. La evidencia fue seleccionada con el objetivo de responder a cada pregunta propuesta. La certeza de la evidencia se evaluó utilizando la metodología Grading of Recommendations Assessment, Development, and Evaluation (GRADE). En sesiones de trabajo periódicas, el GTF utilizó la metodología GRADE para revisar la evidencia y formular 12 recomendaciones (3 recome...
18
tesis de grado
Publicado 2020
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Objetivo: Demostrar que la amplitud de distribución eritrocitaria (ADE) elevada es factor pronóstico de perforación apendicular en apendicitis aguda en el Hospital Militar Central. Material y Métodos: En este estudio bivariado y multivariado, de tipo de casos y controles, retrospectivo, se estudió un total de 156 pacientes con apendicitis aguda, distribuidos en dos grupos: 52 pacientes con perforación apendicular y 104 pacientes sin ella; se calculó el Odds ratio, la prueba U de Mann-Whitney para variables cuantitativas y la prueba Chi cuadrado de Pearson para variables cualitativas. Resultados: La frecuencia de amplitud de distribución eritrocitaria elevada en pacientes con apendicitis aguda y perforación apendicular fue de 38/52 = 73%. La frecuencia de ADE elevada en pacientes con apendicitis aguda sin perforación apendicular fue de 51/104 = 49%. En el análisis, la ADE eleva...
19
artículo
Publicado 2021
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Introduction: This article summarizes the clinical practice guidelines (CPG) for the management of patients with ALL in the Social Security of Peru (EsSalud). Objective: To provide clinical evidence-based recommendations for the evaluation and management of patients with ALL in EsSalud. Methods: A CPG for the diagnosis and management of patients with ALL in EsSalud was developed. To this end, a guideline development group (local GDG) was established, including medical specialists and methodologists. The local GDG formulated 8 clinical questions to be answered by this CPG. Systematic searches of systematic reviews and -when it was considered pertinent- primary studies were conducted in PubMed and CENTRAL during 2019. The evidence to answer each of the posed clinical questions was selected. The quality of the evidence was assessed using the Grading of Recommendations Assessment, Developmen...
20
tesis de grado
Publicado 2024
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Objetivo: llevar a cabo una revisión sistemática exhaustiva, haciendo uso de información científica con bases de datos concerniente a la composición fitoquímica, composición bromatológica, actividad farmacológica y actividad toxicológica que posee la especie Platycladus orientalis (Tuya Oriental o Árbol de la vida). Materiales y métodos: se recopiló y analizó la información de los estudios sobre fitoquímica, bromatología, farmacología y toxicología de Platycladus orientalis, utilizando fuentes primarias de bases de datos como Google Académico, Scopus, PubMed, Biblioteca Virtual en Salud, Scielo y Elsevier. Resultados: a nivel fitoquímico muestran terpenoides, ácidos grasos insaturados, esteroles, aminoácidos y flavonoides. A nivel bromatológico presentaron componentes minerales como el Calcio, Potasio, Hierro, Sodio, Manganeso y Zinc, se midió cenizas totales, hu...
