Childhood cancer in Peru poses a significant public health challenge, with a survival rate of 63.7%. Early detection, crucial for improving this rate, is hindered by access issues and late diagnoses. Symptoms such as persistent fever and abnormal lymph nodes require prompt identification. In 2018, the WHO, in collaboration with St. Jude Children's Research Hospital and the International Society of Paediatric Oncology, launched the Global Initiative for Childhood Cancer, aiming for a 60% survival rate by 2030. Peru, designated as a focal country in 2019, has implemented the CURE ALL technical package, focusing on centers of excellence, universal coverage, treatment regimens, and continuous evaluation. Despite advancements in infrastructure and training, challenges remain. The centralization of services in Lima complicates access for rural regions, and the fragmented healthcare system exac...

Introduction: This article summarizes the clinical practice guideline (CPG) for the treatment of acute lymphoblastic leukemia in pediatric patients. Objective: To provide health professionals with evidence-informed recommendations for the treatment of acute lymphoblastic leukemia in pediatric patients. Methods: A guideline development group (GDG) was formed, including medical specialists and methodologists, which formulated 7 clinical questions. Systematic searches for systematic reviews and –when considered pertinent– primary studies were conducted in PubMed, Central, and Lilacs during June-August 2024. Evidence was selected to answer each of the clinical questions posed. The certainty of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. In periodic work meetings, the GDG used the GRADE methodology to review t...