Sintetizar la mejor evidencia disponible sobre la eficacia y seguridad del esquema de la vacuna conjugada antineumocócica 13 valente seguida de la vacuna polisacárida antineumocócica 23 valente comparada con la vacuna conjugada antineumocócica 13 valente en adultos mayores de 60 años.

Introduction: This article summarizes the clinical practice guideline (CPG) for the treatment of acute lymphoblastic leukemia in pediatric patients. Objective: To provide health professionals with evidence-informed recommendations for the treatment of acute lymphoblastic leukemia in pediatric patients. Methods: A guideline development group (GDG) was formed, including medical specialists and methodologists, which formulated 7 clinical questions. Systematic searches for systematic reviews and –when considered pertinent– primary studies were conducted in PubMed, Central, and Lilacs during June-August 2024. Evidence was selected to answer each of the clinical questions posed. The certainty of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. In periodic work meetings, the GDG used the GRADE methodology to review t...